Abstract:
:Several C-3-substituted beta-carbolines (e.g., the ethyl ester of beta-carboline-3-carboxylic acid) have high affinities for benzodiazepine receptors and can antagonize the principal pharmacologic actions of the benzodiazepines. The observation that some of these compounds also possess 'intrinsic' actions, best described as pharmacologically opposite to the benzodiazepines, has provided a chemically induced model of extreme stress or anxiety. The actions of such compounds in currently used animal models of anxiety are reviewed, as well as the effects of these compounds in primates, including man.
journal_name
Psychopathologyjournal_title
Psychopathologyauthors
Skolnick P,Crawley JN,Glowa JR,Paul SMdoi
10.1159/000284131subject
Has Abstractpub_date
1984-01-01 00:00:00pages
52-60eissn
0254-4962issn
1423-033Xjournal_volume
17 Suppl 3pub_type
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