The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice.

abstract：:Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anasethetized animals ...

journal_title：Cardiovascular research

authors： Hutton I,Marynick SP,Fixler DE,Templeton GH,Willerson JT

更新日期：1975-01-01 00:00:00

abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

journal_title：Cardiovascular research

authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Washed platelets have been shown to protect isolated buffer perfused rat hearts from injury and dysfunction following ischaemia-reperfusion. This study was designed to investigate whether platelet glutathione redox cycle contributes to the protective effect of platelets. METHODS:Isolated rat hearts were perf...

journal_title：Cardiovascular research

authors： Yang BC,Mehta A,Mehta JL

更新日期：1994-10-01 00:00:00

abstract：AIMS:Proliferation of mammalian cardiomyocytes stops during the first weeks after birth, preventing the heart from regenerating after injury. Recently, several studies have indicated that induction of cardiomyocyte proliferation can be utilized to regenerate the mammalian heart. Thus, it is important to identify novel ...

journal_title：Cardiovascular research

authors： Novoyatleva T,Diehl F,van Amerongen MJ,Patra C,Ferrazzi F,Bellazzi R,Engel FB

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The aim was to examine the role of nitric oxide (NO) in the myocardial microcirculation. METHODS:Open chest anaesthetised dogs received intracoronary infusion of NG-monomethyl-L-arginine (L-NMMA; 0.5 mg.kg-1 over 30 min). Myocardial microvascular extraction fraction of a small hydrophilic solute (technetium ...

journal_title：Cardiovascular research

authors： Hansen PR,Haunsø S

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:While atrial natriuretic peptide (ANP) has been shown to be released mainly from cardiac muscle cells in response to atrial distension, the regulatory mechanisms of ANP secretion are still not fully understood. We sought to determine whether the ATP-sensitive K+ (K(ATP)) channel modulates the secretion of ANP...

journal_title：Cardiovascular research

authors： Saegusa N,Sato T,Saito T,Tamagawa M,Komuro I,Nakaya H

更新日期：2005-07-01 00:00:00

abstract：AIMS:Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this study, we investigated the effect of CTLA4-IgG on homocysteine (Hcy)-induced T-cell activation and potential signal pathways involved in atherosclerotic formation. METHODS AND RESULTS:The CD28...

journal_title：Cardiovascular research

authors： Ma K,Lv S,Liu B,Liu Z,Luo Y,Kong W,Xu Q,Feng J,Wang X

更新日期：2013-02-01 00:00:00

abstract：:Congenital coronary artery anomalies are of major significance in clinical cardiology and cardiac surgery due to their association with myocardial ischaemia and sudden death. Such anomalies are detectable by imaging modalities and, according to various definitions, their prevalence ranges from 0.21 to 5.79%. This cons...

journal_title：Cardiovascular research

authors： Pérez-Pomares JM,de la Pompa JL,Franco D,Henderson D,Ho SY,Houyel L,Kelly RG,Sedmera D,Sheppard M,Sperling S,Thiene G,van den Hoff M,Basso C

更新日期：2016-02-01 00:00:00

abstract：AIMS:Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a major COX-2 product, leads to adaptive growth via Stat3 activation, but...

journal_title：Cardiovascular research

authors： Frias MA,Somers S,Gerber-Wicht C,Opie LH,Lecour S,Lang U

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Injury stimulates smooth muscle cell (SMC) migration and proliferation by mechanisms that are incompletely understood. Surgical preparative injury is an important determinant of neointimal thickening in human saphenous vein bypass grafts. We investigate here whether basement-membrane-degrading metalloprotein...

journal_title：Cardiovascular research

authors： George SJ,Zaltsman AB,Newby AC

更新日期：1997-02-01 00:00:00

abstract：AIMS:Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capac...

journal_title：Cardiovascular research

authors： Filgueiras-Rama D,Vasilijevic J,Jalife J,Noujaim SF,Alfonso JM,Nicolas-Avila JA,Gutierrez C,Zamarreño N,Hidalgo A,Bernabé A,Cop CP,Ponce-Balbuena D,Guerrero-Serna G,Calle D,Desco M,Ruiz-Cabello J,Nieto A,Falcon A

更新日期：2020-04-28 00:00:00

abstract：Aims:Atherosclerosis is an inflammatory disease wherein cholesterol-loaded macrophages play a major role. MicroRNAs and microparticles propagate inflammatory pathways and are involved in cardiovascular disease. We aimed to screen and validate circulating microRNAs correlated with atherosclerosis development in humans, ...

journal_title：Cardiovascular research

authors： Ceolotto G,Giannella A,Albiero M,Kuppusamy M,Radu C,Simioni P,Garlaschelli K,Baragetti A,Catapano AL,Iori E,Fadini GP,Avogaro A,Vigili de Kreutzenberg S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The atrial natriuretic peptide (ANP) family is a complex system consisting of at least three polypeptides and at least three types of receptor. Each peptide interacts with different types of receptor at varying degrees of affinity. To determine if natriuretic peptide levels influence natriuretic peptide rece...

journal_title：Cardiovascular research

authors： Vera N,Tse MY,Watson JD,Sarda S,Steinhelper ME,John SW,Flynn TG,Pang SC

更新日期：2000-06-01 00:00:00

abstract：AIMS:Doxorubicin (DOX) is widely used in cytostatic treatments, although it may cause cardiovascular dysfunction as a side effect. DOX treatment leads to enhanced free radical production that in turn causes DNA strand breakage culminating in poly(ADP-ribose) polymerase (PARP) activation and mitochondrial and cellular d...

journal_title：Cardiovascular research

authors： Szántó M,Rutkai I,Hegedus C,Czikora Á,Rózsahegyi M,Kiss B,Virág L,Gergely P,Tóth A,Bai P

更新日期：2011-12-01 00:00:00

abstract：Aims:Endothelial hyperpermeability exacerbates multiple organ damage during inflammation or infection. The endothelial glycocalyx, a protective matrix covering the luminal surface of endothelial cells (ECs), undergoes enzymatic shedding during inflammation, contributing to barrier hyperpermeability. A disintegrin and m...

journal_title：Cardiovascular research

authors： Yang X,Meegan JE,Jannaway M,Coleman DC,Yuan SY

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Increased pulse pressure has been observed in aging subjects, but the impact on the structure and reactivity of small arteries has been scarcely evaluated. METHODS:This study presents the modifications of vascular structure and function observed in female rats of 5, 18 and 32 months of age, and their relatio...

journal_title：Cardiovascular research

authors： Moreau P,d'Uscio LV,Lüscher TF

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Alkalinizing agents reverse cardiotoxicity of a variety of sodium channel blockers, including tricyclic antidepressants, but their mechanisms of action are poorly understood. PURPOSE:To establish the mechanisms by which alkalinization diminishes the sodium channel blocking action of imipramine. METHODS:The...

journal_title：Cardiovascular research

authors： Bou-Abboud E,Nattel S

更新日期：1998-05-01 00:00:00

abstract：AIMS:Despite their ability to cause septic shock and myocardial dysfunction, components of Gram-negative bacterial cell walls, like lipopolysaccharide, have been shown in numerous studies to induce myocardial protection during ischaemia-reperfusion injury. Muramyl dipeptide (MDP) is another such component recognized by...

journal_title：Cardiovascular research

authors： Sicard P,Jacquet S,Kobayashi KS,Flavell RA,Marber MS

更新日期：2009-07-15 00:00:00

abstract：OBJECTIVE:AMP conversion to adenosine by cytosolic 5'nucleotidase (5NT) or to IMP by AMP deaminase determines the degree of nucleotide degradation, and thus ATP resynthesis, during reoxygenation. To elucidate the regulation of AMP hydrolysis during ischemia, data from 31P NMR spectroscopy and biochemical analyses were ...

journal_title：Cardiovascular research

authors： Gustafson LA,Zuurbier CJ,Bassett JE,Barends JP,van Beek JH,Bassingthwaighte JB,Kroll K

更新日期：1999-11-01 00:00:00

abstract：AIMS:The human ether-a-go-go-related gene (hERG) encodes the rapidly activating delayed rectifier potassium channel (IKr). Malfunction of hERG/IKr is the primary cause of acquired long QT syndrome (LQTS), an electrical disorder of the heart that can cause arrhythmias and sudden death. Patients with autoimmune diseases ...

journal_title：Cardiovascular research

authors： Szendrey J,Lamothe SM,Vanner S,Guo J,Yang T,Li W,Davis J,Joneja M,Baranchuk A,Zhang S

更新日期：2019-08-01 00:00:00

abstract：:Arteriogenesis, the process of collateral artery growth as an adaptation to major arterial occlusion, can be life- and tissue saving and may alter the natural course of the consequences and organ manifestations of arterial disease. This is achieved by an active growth process that is coupled to complete arterial remod...

journal_title：Cardiovascular research

authors： Schaper W,Buschmann I

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. METHODS AND RESULTS:Adenosine significantly enhanced the fluorescence of DAF-FM, a dye specific for NO, implying that adenosine induces synthesis of NO. Adenosine-induced NO production...

journal_title：Cardiovascular research

authors： Xu Z,Park SS,Mueller RA,Bagnell RC,Patterson C,Boysen PG

更新日期：2005-03-01 00:00:00

abstract：:Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD...

journal_title：Cardiovascular research

authors： Patel AP,Natarajan P

更新日期：2019-04-15 00:00:00

abstract：AIMS:Mast cells participate importantly in abdominal aortic aneurysms (AAAs) by releasing inflammatory cytokines to promote vascular cell protease expression and arterial wall remodelling. Mast cells accumulate in AAA lesions during disease progression, but the exact chemokines by which mast cells migrate to the site o...

journal_title：Cardiovascular research

authors： Zhang J,Chen H,Liu L,Sun J,Shi MA,Sukhova GK,Shi GP

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-9 (MMP-9) activity is up regulated in the heart subjected to ischemic insult. Whether increased MMP-9 activity contributes to acute myocardial injury after ischemia-reperfusion remains unknown. To investigate the role of MMP-9 in myocardial infarction, we utilized a MMP-9 knockout mou...

journal_title：Cardiovascular research

authors： Romanic AM,Harrison SM,Bao W,Burns-Kurtis CL,Pickering S,Gu J,Grau E,Mao J,Sathe GM,Ohlstein EH,Yue TL

更新日期：2002-06-01 00:00:00

abstract：:Nitric oxide (NO) is a highly reactive, free radical signalling molecule that is constitutively released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide synthase (eNOS and nNOS, respectively). There are increasing data indicating that NO modulates various proteins involved in excitation...

journal_title：Cardiovascular research

authors： Lim G,Venetucci L,Eisner DA,Casadei B

更新日期：2008-01-15 00:00:00

abstract：:One of the striking differences that distinguish the adult from the embryonic heart in mammals and set it apart from the heart in urodeles and teleosts is the incapacity of cardiomyocytes to respond to damage by proliferation. While the molecular reasons underlying these characteristics still await elucidation, mounti...

journal_title：Cardiovascular research

authors： Zacchigna S,Giacca M

更新日期：2014-05-01 00:00:00

abstract：AIMS:We analysed the possible protective role of human endothelial (EPCs) and smooth muscle (SPCs) progenitor cells on atherosclerosis development in apoE(-/-)RAG2(-/-) mice. We determined plasma levels of SPCs in coronary patients. METHODS AND RESULTS:ApoE(-/-)RAG2(-/-) mice received four intravenous injections of sa...

journal_title：Cardiovascular research

authors： Zoll J,Fontaine V,Gourdy P,Barateau V,Vilar J,Leroyer A,Lopes-Kam I,Mallat Z,Arnal JF,Henry P,Tobelem G,Tedgui A

更新日期：2008-02-01 00:00:00

abstract：:The last decade has seen a dramatic increase in the understanding of the molecular basis of arrhythmias. Much of this new information has been driven by genetic studies that focused on rare, monogenic arrhythmia syndromes that were accompanied or followed by cellular electrophysiological or biochemical studies. The ma...

journal_title：Cardiovascular research

authors： Kääb S,Schulze-Bahr E

更新日期：2005-08-15 00:00:00

abstract：:The effect of chronic propranolol administration (2 mg.kg-1.d-1 for 14d) and withdrawal on microvascular perfusion was studied in rabbit myocardium. Fluorescein isothiocyanate-dextran was injected into four groups of anaesthetised open chest rabbits. Fluorescent microscopy was used to identify the perfused vessels and...

journal_title：Cardiovascular research

authors： Acad BA,Shenko JM,Eliades D,Weiss HR

更新日期：1988-11-01 00:00:00