Abstract:
:The co-operative effects of recombinant human tumor necrosis factor (rH-TNF) and CPT-11, a new derivative of camptothecin, against the proliferation of human gynecologic tumor cell lines were examined in vitro. The ishikawa cells were responsive to rH-TNF, the HHUA cells exhibited a minimal degree of responsiveness to rH-TNF, and the HeLa S3 and Caov-3 cells were unresponsive to rH-TNF. The HHUA, Ishikawa and Caov-3 cells were responsive to CPT-11, and the HeLa S3 cells were relatively sensitive to CPT-11 cytotoxicity. In all four cell lines, rH-TNF at clinically achievable concentrations exhibited synergy with CPT-11. The combination therapy of rH-TNF and CPT-11 will be a new approach against gynecologic cancers.
journal_name
Anticancer Drugsjournal_title
Anti-cancer drugsauthors
Mori H,Sawairi M,Itoh N,Hanabayashi T,Kondoh H,Tamaya Tdoi
10.1097/00001813-199110000-00006subject
Has Abstractpub_date
1991-10-01 00:00:00pages
469-74issue
5eissn
0959-4973issn
1473-5741journal_volume
2pub_type
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