Diffusely increased insertional activity: "EMG disease" or asymptomatic myotonia congenita? A report of 2 cases.

Abstract:

:The term "EMG disease" is used by some to describe the unexpected finding of diffusely increased insertional activity on needle electromyography in an otherwise asymptomatic person. The cause is unknown, but it has been hypothesized that these patients actually have a subclinical myotonic disorder. We describe 2 patients with diffusely increased insertional activity on electromyography who had mutations of the CLCN1 gene associated with myotonia congenita. Neither patient had symptoms or reproducible signs of this disorder. We propose that asymptomatic patients with CLCN1 mutations may at least partially account for the EMG disease phenotype.

journal_name

Arch Phys Med Rehabil

authors

Mitchell CW,Bertorini TE

doi

10.1016/j.apmr.2007.06.013

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

1212-3

issue

9

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(07)00432-7

journal_volume

88

pub_type

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