Abstract:
:Different anesthetic techniques have been suggested for craniotomy with intraoperative awakening. We describe an asleep-awake-asleep technique with propofol and remifentanil infusions, with pharmacokinetic simulation to predict the effect-site concentrations and to modulate the infusion rates of both drugs, and bispectral index (BIS) monitoring. Five critical moments were defined: first loss of consciousness (LOC1), first recovery of consciousness (ROC1), final of neurologic testing (NT), second loss of consciousness (LOC2), and second recovery of consciousness (ROC2). At LOC1, predicted effect-site concentrations of propofol and remifentanil were, respectively, 3.6+/-1.2 microg/mL and 2.4+/-0.4 etag/mL. At ROC1, predicted effect-site concentrations of propofol and remifentanil were, respectively, 2.1+/-0.3 microg/mL and 1.8+/-0.3 etag/mL. At NT, predicted effect-site concentrations of propofol and remifentanil were, respectively, 0.9+/-0.3 microg/mL and 1.8+/-0.2 etag/mL. At LOC2, predicted effect-site concentrations of propofol and remifentanil were, respectively, 2.1+/-0.2 microg/mL and 2.5+/-0.2 etag/mL. At ROC2, predicted effect-site concentrations of propofol and remifentanil were, respectively, 1.2+/-0.5 microg/mL and 1.4+/-0.2 etag/mL (data are mean+/-SE). A significative correlation was found between BIS and predicted effect-site concentrations of propofol (r=0.547, P<0.001) and remifentanil (r=0.533, P<0.001). Multiple regression analysis between BIS and propofol and remifentanil predicted effect-site concentrations at the different critical steps of the procedure was done and found also significative (r=0.7341, P<0.001).
journal_name
J Neurosurg Anesthesioljournal_title
Journal of neurosurgical anesthesiologyauthors
Lobo F,Beiras Adoi
10.1097/ANA.0b013e31805f66adsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
183-9issue
3eissn
0898-4921issn
1537-1921pii
00008506-200707000-00007journal_volume
19pub_type
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journal_title:Journal of neurosurgical anesthesiology
pub_type: 杂志文章
doi:10.1097/00008506-199604000-00006
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
pub_type: 杂志文章
doi:10.1097/00008506-199304000-00009
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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abstract::Intraoperative brain surface electrocorticography (ECoG) is an integral part of the surgical excision of epileptogenic foci. If surgical excision is performed under general anesthesia, anesthetics should be selected that do not seriously interfere with the ECoG. We report a case where nitrous oxide appeared to suppres...
journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
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journal_title:Journal of neurosurgical anesthesiology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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