Abstract：
OBJECTIVES:To compare the in vitro activity of linezolid with 12 other antimicrobials against 190 strains of the coryneform bacteria, including 60 strains of C. amycolatum, 30 of C. striatum, 30 of C. jeikeium, 10 of C. urealyticum, 20 of B. casei, 20 of D. hominis and 20 of T. otitidis. METHODS:Minimum inhibitory concentrations (MICs) and time-death curves were carried out according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI). RESULTS:Linezolid was very active against the 130 strains of the Corynebacterium species studied. Only the glycopeptides showed similar efficacy. In contrast, penicillin G, ampicillin, macrolides, lincosamides, fluoroquinolones and aminoglycosides showed generally high MICs. Among the beta-lactams, only imipenem was active against the majority of strains of C. striatum and C. amycolatum, and, approximately half of the C. jeikeium and C. urealyticum isolates. Both Dermabacter hominis and Brevibacterium casei showed marked resistance against most of the antimicrobials tested, while Turicella otitidis only showed high MICs against macrolides and clindamycin. For all of them, linezolid, vancomycin and teicoplanin proved effective. The time-death curves showed linezolid to behave as a bacteriostatic agent (approximately 90% death rate). Such activity was more accentuated for C. amycolatum and C. striatum (reduction of 1.3 and 1.7log(10)CFU/mL, respectively) than for C. jeikeium and C. urealyticum (reduction of 1.0 and 0.8log(10), respectively). CONCLUSIONS:Our results indicate that linezolid is active against coryneform bacteria. The efficacy of linezolid is equal to or even superior to that of the glycopeptides.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Gómez-Garcés JL,Alos JI,Tamayo Jdoi
10.1016/j.ijantimicag.2006.11.032subject
Has Abstractpub_date
2007-06-01 00:00:00pages
688-92issue
6eissn
0924-8579issn
1872-7913pii
S0924-8579(07)00083-0journal_volume
29pub_type
杂志文章abstract：:Wide-spectrum quinolones such as moxifloxacin and levofloxacin as well as high-order cephalosporins such as cefoperazone and cefepime have increased antimicrobial activity. However, little is known about their distribution in fetal blood. Therefore, the aim of this study was to measure and compare maternal and fetal b...
journal_title：International journal of antimicrobial agents
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pub_type： 临床试验,杂志文章
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journal_title：International journal of antimicrobial agents
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更新日期：2017-08-01 00:00:00
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更新日期：2003-03-01 00:00:00
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journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2005-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
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更新日期：2016-12-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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journal_title：International journal of antimicrobial agents
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更新日期：2004-09-01 00:00:00
