Toxicity from the use of niacin to beat urine drug screening.

Abstract:

:Niacin (vitamin B3) is promoted for rapidly clearing the body of drugs of abuse, such as cocaine and cannabis, and is alleged to interfere with urine drug screening. We present 4 cases of such novel use associated with significant adverse effects. Two cases had isolated skin manifestations, whereas the other 2 presented with life-threatening manifestations, including nausea, vomiting, dizziness, hepatotoxicity, metabolic acidosis, and hypoglycemia evolving into hyperglycemia. One patient also had profound neutrophilia and QT(C)-interval prolongation. All patients improved after cessation of the drug use and supportive treatment. Health care providers should be aware of these potential adverse effects of niacin and of the misguided use of this vitamin by patients seeking to interfere with urine drug screening.

journal_name

Ann Emerg Med

authors

Mittal MK,Florin T,Perrone J,Delgado JH,Osterhoudt KC

doi

10.1016/j.annemergmed.2007.01.014

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

587-90

issue

5

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(07)00074-1

journal_volume

50

pub_type

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