Comparison of human papilloma virus testing and spectroscopy combined with cervical cytology for the detection of high-grade cervical neoplasia.

Abstract:

OBJECTIVE:This study compared the performance of cervical cytology plus human papilloma virus testing (Pap + HPV) or cervical spectroscopy (Pap + CS) for identifying high-grade cervical neoplasia in a high-risk population of women referred for colposcopy. MATERIALS AND METHODS:Each of 113 subjects underwent spectroscopy, thin-layer cytology, HPV testing, colposcopy, biopsy when indicated, and/or endocervical curettage. Evaluable data for analysis were collected for 102 of the subjects. Sensitivity and specificity were calculated for both strategies. RESULTS:Pap + HPV and Pap + CS achieved equivalent sensitivities (95%) for high-grade lesions, with both detecting 17 of 18 histology confirmed cervical intraepithelial neoplasia (CIN) 2+ lesions. Pap + HPV had a specificity of only 27.4% compared with 65.5% for Pap + CS (p < .0001). CONCLUSIONS:Spectroscopic interrogation of the cervix is equally sensitive and 2-fold more specific than HPV testing when combined with cervical cytology for identifying high-grade cervical neoplasia.

journal_name

J Low Genit Tract Dis

authors

Werner CL,Griffith WF 3rd,Ashfaq R,Gossett D,Wilkinson E,Raab S,Bambot S,Mongin D,Faupel M

doi

10.1097/01.lgt.0000230208.58118.58

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

73-9

issue

2

eissn

1089-2591

issn

1526-0976

pii

00128360-200704000-00003

journal_volume

11

pub_type

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