Abstract：
:The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal cellular development and cell survival. The initial discovery of WT1 as the causative gene in an autosomal-recessive condition identified it as a tumor suppressor gene whose mutations are associated with urogenital disease and the development of kidney tumors. However, this view is not in keeping with the frequent finding of wild-type, full-length WT1 in human leukemia, breast cancer and several other cancers including the majority of Wilms' tumors. Rather, these observations suggest that in those conditions, WT1 has an oncogenic role in tumor formation. In this review, we explore the literature supporting both views of WT1 in human cancer and in particular human leukemias. To understand the mechanism by which WT1 can do this, we will also examine its functional activity as a transcription factor and the influence of protein partners on its dual behavior.
journal_name
Leukemiajournal_title
Leukemiaauthors
Yang L,Han Y,Suarez Saiz F,Minden MDdoi
10.1038/sj.leu.2404624subject
Has Abstractpub_date
2007-05-01 00:00:00pages
868-76issue
5eissn
0887-6924issn
1476-5551pii
2404624journal_volume
21pub_type
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