Abstract:
:Charcot-Marie-Tooth disease (CMT) is classified into two types, the demyelinating (CMT1) and axonal forms (CMT2). CMT2 is further subdivided by linkage analysis into eight subgroups. Recently, mutations in the MFN2 gene, which encodes the mitochondrial GTPase mitofusin 2 (Mfn2) that regulates the mitochondrial network architecture by fusing the mitochondria, were identified in CMT2A patients. This study carried out mutation analysis of the MFN2 gene in 12 unrelated Korean patients suspected of having CMT2 and identified four mutations (Arg94Trp, His165Arg, Ser263Pro, and Ser350Pro). Three mutations were found within the highly conserved GTPase domain that is essential for the function of Mfn2, and one mutation (Ser350Pro) was observed between the GTPase domain and the downstream coiled-coil domain. This suggests that mutations in the MFN2 gene are an important causative gene underlying Korean patients with CMT2, and screening for a mutation in the MFN2 gene is strongly recommended for making a molecular diagnosis of CMT2.
journal_name
Clin Genetjournal_title
Clinical geneticsauthors
Cho HJ,Sung DH,Kim BJ,Ki CSdoi
10.1111/j.1399-0004.2007.00763.xsubject
Has Abstractpub_date
2007-03-01 00:00:00pages
267-72issue
3eissn
0009-9163issn
1399-0004pii
CGE763journal_volume
71pub_type
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pub_type: 信件
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