Role of endothelium-derived relaxing factor in endothelin-induced renal vasoconstriction.

abstract：:The aim of this study was to compare the effects of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the angiotensin II antagonist losartan on insulin sensitivity and plasma fibrinogen in overweight hypertensive patients. Twenty-eight overweight mild to moderate [diastolic blood pressure (DBP) >90 and...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Zoppi A,Lazzari P,Preti P,Mugellini A,Corradi L,Lusardi P

更新日期：1998-10-01 00:00:00

abstract：:Guanfacine 3 mg was infused into six volunteers over 1 h on two occasions to investigate whether its sympatholytic effect is centrally or peripherally mediated. On one occasion, the central effects of guanfacine were blocked by prior administration of idazoxan 0.2 mg/kg i.v. (45 min preguanfacine); central alpha 2-blo...

journal_title：Journal of cardiovascular pharmacology

authors： Brown MJ,Struthers AD,di Silvio L

更新日期：1985-01-01 00:00:00

abstract：:Endothelin (ET) may play an important role in the pathogenesis of vasoconstriction and acute renal failure after aortic cross-clamping (ACC). However, the relative contribution of the ET(A) and ET(B) receptors to the physiopathology of ischemic acute renal failure is poorly understood. This study was carried out to ev...

journal_title：Journal of cardiovascular pharmacology

authors： Roux S,Qiu C,Sprecher U,Osterwalder R,Clozel JP

更新日期：1999-08-01 00:00:00

abstract：:The angiotensin II receptor-1 blockers have generally been shown to have antiatherogenic effects, and dendritic cells (DCs) are the most efficient antigen presenting cells that play an active role in the development of atherosclerosis through inflammatory-immune responses. Here, we tested the hypothesis that the antia...

journal_title：Journal of cardiovascular pharmacology

authors： Huang D,Lu H,Liu H,Yao K,Sun A,Zou Y,Ge J

更新日期：2012-08-01 00:00:00

abstract：:Lidocaine and tocainide had no effect on ventricular conduction of extrasystoles with coupling intervals longer than 500 msec in isolated blood-perfused dog hearts, but caused interval-related increases in conduction time of extrasystoles in the range of 250--400 msec, here called mid-range extrasystoles (MRE). Quinid...

journal_title：Journal of cardiovascular pharmacology

authors： Man RY,Dresel PE

更新日期：1979-05-01 00:00:00

abstract：:The quantitative receptor autoradiographic method we used revealed that specific [125I]endothelin-1 ([125I]ET-1) binding sites are highly concentrated in the choroid plexus (ChP), subfornical organ (SFO), lacunosum molecular layer of the hippocampus (LMol), and granular layer of the cerebellum (GC) of the rat brain. [...

journal_title：Journal of cardiovascular pharmacology

authors： Niwa M,Kawaguchi T,Fujimoto M,Kataoka Y,Taniyama K

更新日期：1991-01-01 00:00:00

abstract：:In isolated rat tail arteries perfused with Krebs-Henseleit solution, ouabain, in concentrations of less than 10(-5) M, caused a concentration-dependent, noncompetitive inhibition of the vasoconstrictor response to phenylephrine. Concentrations of 10(-8) and 10(-6) M caused 30 and 61% inhibition, respectively. The inh...

journal_title：Journal of cardiovascular pharmacology

authors： Armsworth SJ,Marwood JF,Stokes GS

更新日期：1985-07-01 00:00:00

abstract：:The oral anticoagulant edoxaban, a factor Xa inhibitor, will likely be coadministered with digoxin in some patients with atrial fibrillation. Both drugs are substrates for P-glycoprotein. The objective of this phase 1, parallel study was to assess the effects of coadministration of both drugs on their respective pharm...

journal_title：Journal of cardiovascular pharmacology

authors： Mendell J,Noveck RJ,Shi M

更新日期：2012-10-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors are widely used for treatment of heart failure after myocardial infarction (MI). The beneficial effects consist of a combination of hemodynamic effects and interference with cardiac structural alterations. These effects are believed to depend on inhibition of angiotensin ...

journal_title：Journal of cardiovascular pharmacology

authors： Smits JF,van Krimpen C,Schoemaker RG,Cleutjens JP,Daemen MJ

更新日期：1992-01-01 00:00:00

abstract：:Increased levels of endothelin (ET) have been demonstrated in the ischemic brain, and ET receptor antagonism has been shown to improve outcome in cerebral ischemia. However, no previous work has been carried out evaluating the role of ET and its antagonism in brain trauma as compared to experimental stroke. In this st...

journal_title：Journal of cardiovascular pharmacology

authors： Barone FC,Ohlstein EH,Hunter AJ,Campbell CA,Hadingham SH,Parsons AA,Yang Y,Shohami E

更新日期：2000-11-01 00:00:00

abstract：:The effect of two calcium antagonists on left ventricular (LV) relaxation and diastolic filling was evaluated in 16 randomized patients. Isradipine and nifedipine were administered intravenously in a maximum dose of 60 micrograms/min for isradipine and 63 micrograms/min for nifedipine. Heart rate was increased signifi...

journal_title：Journal of cardiovascular pharmacology

authors： Hoppeler H,Hess OM,Hug R,Turina J,Krayenbühl HP

更新日期：1990-01-01 00:00:00

abstract：:This study determined whether flavin adenine dinucleotide (FAD) may elicit vasodilation in conscious rats via release of preformed endothelium-derived nitrosyl factors. Injections 1-6 (inj(1-6)) of FAD (2.5 micromol/kg, IV) elicited pronounced and equivalent vasodilator responses in saline-treated rats. Inj(1) of FAD ...

journal_title：Journal of cardiovascular pharmacology

authors： Hashmi-Hill MP,Sandock K,Bates JN,Robertson TP,Lewis SJ

更新日期：2007-08-01 00:00:00

abstract：:The effects of prenylamine (PNL) and AQ-A 39 on sustained ventricular tachycardia (SVT) were studied by programmed stimulation in conscious dogs 4-10 days after ligation of the left anterior descending (LAD) coronary artery. In 8 of 16 dogs developing SVT in the control, PNL (3 mg/kg intravenously, i.v.) suppressed in...

journal_title：Journal of cardiovascular pharmacology

authors： Aidonidis I,Egel E,Hilbel T,Kuebler W,Brachmann J

更新日期：1993-09-01 00:00:00

abstract：:The vulnerable period (VP) is an interval of time during the cardiac cycle within which premature stimulation may lead to trains of responses (one: many stimulus-response coupling). Although the VP parallels the recovery of sodium channel availability, modulators of its boundaries remain unclear. Numerical studies of ...

journal_title：Journal of cardiovascular pharmacology

authors： Nesterenko VV,Lastra AA,Rosenshtraukh LV,Starmer CF

更新日期：1992-05-01 00:00:00

abstract：UNLABELLED:The role of mitochondrial transporters in the cardioprotection of rat hearts exposed to high [K+]-low [Ca2+]-cardioplegia (CPG) and ischemia and reperfusion (I/R) was studied through the mechano-energetic consequences of target drugs. The total heat rate (Ht) and the left intraventricular pressure (LVP) were...

journal_title：Journal of cardiovascular pharmacology

authors： Ragone MI,Consolini AE

更新日期：2009-09-01 00:00:00

abstract：:Long-term exposure of endothelial cells to molsidomine in vivo and in vitro improves the thromboresistance of endothelial cells, judging from the inhibition of platelet aggregation by endothelial cells in autologous plasma. In cultured endothelial cells, the present studies attempted (a) to show that platelets influen...

journal_title：Journal of cardiovascular pharmacology

authors： Berenger-Bahuet FP,Rolland PH

更新日期：1989-01-01 00:00:00

abstract：:Since minoxidil was previously shown to raise plasma renin activity (PRA) but not the plasma aldosterone concentration (PAC), the effect of minoxidil on the rate of aldosterone metabolic clearance was studied. After the addition of minoxidil to the antihypertensive regimen of 7 hypertensive patients, the aldosterone m...

journal_title：Journal of cardiovascular pharmacology

authors： Pratt JH,Yager CJ,Grim CE,Parkinson CA

更新日期：1980-01-01 00:00:00

abstract：:In conscious rats, intrathecal (i.t.) administration of norepinephrine (NE) produced pressor responses, whereas i.t. epinephrine (Epi) caused depressor responses at low doses (0.1-1 microgram) and pressor responses at a higher dose (10 micrograms). Epi administered i.t. produced bradycardia; however, NE caused tachyca...

journal_title：Journal of cardiovascular pharmacology

authors： Gradin K,Nicholas AP,Hjemdahl P,Svensson T,Hökfelt T

更新日期：1992-09-01 00:00:00

abstract：:Activating IK1 channels is considered to be a promising antiarrhythmic strategy. Zacopride has been identified as a selective IK1 channel agonist and can suppress triggered arrhythmias. Whether this drug also exerts a beneficial effect on cardiac remodeling is unknown, and the present study sought to address this ques...

journal_title：Journal of cardiovascular pharmacology

authors： Liu CF,Liu QH,Liu EL,Zhai XW,Zhang L,Luo TE,Zhang WF,Feng QL,Cui XL,Zhao ZQ,Cao JM,Wu BW

更新日期：2014-10-01 00:00:00

abstract：ABSTRACT:Lipid metabolism disorder and inflammatory response are considered to be the major causes of atherosclerogenesis. Astragalin, the most important functional component of flavonoid obtained from persimmon leaves, has the hypolipidemic effects. However, it is unknown, how astragalin protects against atheroscleros...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao ZW,Zhang M,Wang G,Zou J,Gao JH,Zhou L,Wan XJ,Zhang DW,Yu XH,Tang CK

更新日期：2020-10-30 00:00:00

abstract：:Endothelin-B- (ETB) receptors located in vascular beds mainly mediate vasorelaxation, however, long-term treatment with a mixed ETA/ETB receptor antagonist has been shown to improve the survival rate of rats with heart failure in a similar way to ETA-receptor inhibitors. The inhibition of ETB-receptor-mediated action ...

journal_title：Journal of cardiovascular pharmacology

authors： Sawaki M,Wada A,Tsutamoto T,Ohnishi M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:Arterial vascular resistance is established by myogenic mechanisms and is modulated both by local factors such as vasodilator metabolites and by remote controls of neurogenic and hormonal origin. This paper reports on the effects of felodipine and hydralazine on the myogenic tone and the neurogenic control of the vasc...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Thalén P

更新日期：1987-01-01 00:00:00

abstract：:To investigate the role of endothelin (ET) in severe hypertension, endothelial dysfunction hypercholesterolemic stroke-prone spontaneously hypertensive rats (SHRSP on a 5% cholesterol diet) were additionally fed with 1% NaCl and 0.023% nitro-L-arginine. Under these conditions, all untreated rats died within 30 days (m...

journal_title：Journal of cardiovascular pharmacology

authors： Münter K,Hergenröder S,Kirchengast M

更新日期：1998-01-01 00:00:00

abstract：:An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

journal_title：Journal of cardiovascular pharmacology

authors： Haïat R,Piot O,Gallois H,Hanania G

更新日期：1999-06-01 00:00:00

abstract：:The serotonin-2 receptor antagonist ketanserin has been suggested to diminish arteriosclerotic development by its effect on platelet function and on vascular smooth muscle cells. We investigated the ability of ketanserin in reducing immune-mediated arteriosclerosis using the BN-WAG and WAG-BN rat aortic transplantatio...

journal_title：Journal of cardiovascular pharmacology

authors： Geerling RA,de Bruin RW,Scheringa M,Bonthuis F,IJzermans JN,Marquet RL

更新日期：1996-03-01 00:00:00

abstract：:The pharmacologic profile of SK-1080, a nonpeptide AT1-selective angiotensin-receptor antagonist, was investigated by receptor-binding studies, functional in vitro assays with rabbit and rat aorta, and in vivo experiments in pithed rats. SK-1080 inhibited the specific binding of [125I]-[Sar1, Ile8]-angiotensin II to h...

journal_title：Journal of cardiovascular pharmacology

authors： Lee SH,Jung YS,Lee BH,Yun SI,Yoo SE,Shin HS

更新日期：1999-03-01 00:00:00

abstract：:Adenosine and verapamil have successfully been used in the treatment of clinical no-reflow after direct angioplasty for acute myocardial infarction. However, their effects on anatomic perfusion defects in experimental myocardial ischemia/reperfusion are unknown. Thus the area of no-reflow (ANR), visualized after in-vi...

journal_title：Journal of cardiovascular pharmacology

authors： Reffelmann T,Kloner RA

更新日期：2004-04-01 00:00:00

abstract：:In this study, we compared the effect of the essential oil of Citrus bergamia Risso [bergamot, bergamot essential oil (BEO)] on the intracellular Ca levels in vascular endothelial (EA) and mouse vascular smooth muscle (MOVAS) cells, using the fura-2 fluorescence technique. BEO caused an initial transient increase in i...

journal_title：Journal of cardiovascular pharmacology

authors： You JH,Kang P,Min SS,Seol GH

更新日期：2013-04-01 00:00:00

abstract：:The complex formed between endothelin (ET) and its binding protein was adequately stable to be separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) at low temperature. Cross-linking was not necessary. This simple method was applied for both qualitative (determination of molecular weight ...

journal_title：Journal of cardiovascular pharmacology

authors： Takasuka T,Satoh N,Horii I,Furuichi Y,Watanabe T

更新日期：1991-01-01 00:00:00

abstract：:The possible relevance of intrinsic sympathomimetic activity (ISA) for beta-blocker-induced changes in plasma lipids was investigated by reviewing the literature and analyzing the results separately for nonselective beta-blockers, beta 1-selective beta-blockers, and those possessing ISA. It was confirmed that with the...

journal_title：Journal of cardiovascular pharmacology

authors： van Brummelen P

更新日期：1983-01-01 00:00:00