Receptors for endothelin in the central nervous system.

abstract：:Nitric oxide (NO) is a potent inhibitor of platelet aggregation. However, the benefits of NO-based therapies can be confounded by concomitant hypotension. Monophosphoryl lipid A (MLA) is a nontoxic derivative of endotoxin that purportedly increases nitric oxide synthase (NOS) activity and, presumably, NO production, y...

journal_title：Journal of cardiovascular pharmacology

authors： Przyklenk K,Hata K,Whittaker P,Elliott GT

更新日期：2000-03-01 00:00:00

abstract：:The mechanisms of sustained ventricular tachycardia (VT) induced by large cumulative dose of cesium chloride (Cs) remains unclear. Seven anesthetized rabbits were intravenously injected with Cs (1 mmol/kg) 3 times at 20-min intervals. The surface ECG and monophasic action potential of the left ventricular endocardium ...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi N,Ito M,Fujino T,Iwao T,Nakagawa M,Yonemochi H,Saikawa T,Sakata T

更新日期：1998-05-01 00:00:00

abstract：:Bezafibrate, a potent hypolipidemic agent, was studied as potentially preventive in the atherosclerosis-associated vascular hyperresponsiveness to alpha-adrenoceptors agonists in rats. Contractile responses to norepinephrine (NE) were determined in isolated tail arteries of rats fed an atherogenic or a standard diet. ...

journal_title：Journal of cardiovascular pharmacology

authors： Trzeciak HI,Okopień B,Kozłowski A,Chociłowska D,Bara A

更新日期：1993-11-01 00:00:00

abstract：:An attempt was made to study possible interaction between neuromodulation by adenosine and nicotine stimulatory effects. Dose-effect curves were made double blind in 7 nonsmoking, nonsnuffing healthy volunteers (25-49 years) before and during exposition to nicotine roughly corresponding to the nicotine of one cigarett...

journal_title：Journal of cardiovascular pharmacology

authors： Sylvén C,Beermann B,Kaijser L,Jonzon B

更新日期：1990-12-01 00:00:00

abstract：:Apoptosis, a genetically controlled programmed cell death, has been found to play a role in ischemic reperfusion injury in several animal species including rats and rabbits. To examine whether this also is true for other animals, a surgically relevant model was established using an isolated in situ swine heart. Hearts...

journal_title：Journal of cardiovascular pharmacology

authors： Maulik N,Yoshida T

更新日期：2000-11-01 00:00:00

abstract：:A great number of calcium antagonists are available for the treatment of cardiovascular diseases. Differences in pharmacodynamic and/or pharmacokinetic properties can be used to optimize therapy in patients and to minimize side effects. In contrast to all dihydropyridine (DHP) derivatives, drugs of the verapamil type ...

journal_title：Journal of cardiovascular pharmacology

authors： Borchard U

更新日期：1994-01-01 00:00:00

abstract：:The actions of prostacyclin and its synthetic analog iloprost on the release and action of platelet-derived serotonin (5-HT) and thromboxane (TX) A2 were studied in vitro. Washed human platelet suspensions (WPS) (4 X 10(8) platelets/ml) were stimulated with arachidonic acid (AA) (30 mumol/L) and the incubate transferr...

journal_title：Journal of cardiovascular pharmacology

authors： Schrör K,Verheggen R

更新日期：1986-05-01 00:00:00

abstract：:Calcium is a signaling element of general importance to cells. In muscle, its key function is the activation of troponin C, which is essential for the contraction of myofibrils in skeletal and heart muscles, and of myosin light chain kinase, which is essential for the contraction of smooth muscles. Calcium modulates t...

journal_title：Journal of cardiovascular pharmacology

authors： Carafoli E

更新日期：1988-01-01 00:00:00

abstract：:We compared platelet function results obtained with the VerifyNow P2Y12 (VN-P2Y12) point-of-care device and the light transmission aggregometry (5 and 20 microM adenosine diphosphate) method using an integrated database of eight clinical trials with a total of 591 subjects. The study was performed in healthy subjects,...

journal_title：Journal of cardiovascular pharmacology

authors： Jakubowski JA,Li YG,Small DS,Payne CD,Tomlin ME,Luo J,Winters KJ

更新日期：2010-07-01 00:00:00

abstract：:Hypertension is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effects of veratric acid (VA) on blood pressure, plasma, and tissue lipid profile in N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Hypert...

journal_title：Journal of cardiovascular pharmacology

authors： Saravanakumar M,Raja B

更新日期：2012-06-01 00:00:00

abstract：:The calcium channel blocker nifedipine and the new phosphodiesterase (PDE) inhibitor enoximone are used in the treatment of cardiovascular diseases. Since both substances are acting on slow calcium channels and because systemic elimination of these two agents is dependent on oxidative drug metabolizing enzyme activity...

journal_title：Journal of cardiovascular pharmacology

authors： Boldt J,Kling D,Dietevich HA,Hempelmann G

更新日期：1990-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) has been proven to activate two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC) in rabbit internal carotid artery vascular smooth muscle cells (ICA VSMCs). Ca2+ influx through these channels plays an essential role for ET-...

journal_title：Journal of cardiovascular pharmacology

authors： Kawanabe Y,Hashimoto N,Masaki T

更新日期：2002-08-01 00:00:00

abstract：:The pharmacokinetics of losartan and EXP3174, an active metabolite of losartan, were evaluated in the anesthetized pig after both a single intravenous dose (3 mg/kg) and during constant intravenous infusion. The pharmacodynamic activities of losartan and EXP3174 were determined during constant intravenous infusion as ...

journal_title：Journal of cardiovascular pharmacology

authors： Lankford SM,Plummer D,Hellyer P,Christ DD,Bai SA

更新日期：1997-11-01 00:00:00

abstract：:The present study, undertaken in general practice, was designed to evaluate the effects of age on the pharmacodynamics and pharmacokinetics of a conventional and a slow-release formulation (Securon SR) of verapamil. Two groups of 12 patients with essential hypertension were treated in an open, randomized, crossover st...

journal_title：Journal of cardiovascular pharmacology

authors： Hosie J,Hosie G,Meredith PA

更新日期：1989-01-01 00:00:00

abstract：:To evaluate the role of angiotensin II (AII) on diastolic function during post-myocardial infarction (MI) ventricular remodeling, coronary ligation or sham operation was performed in male Sprague-Dawley rats. Experimental animals were maintained on either irbesartan, a selective AT1-receptor antagonist, or no treatmen...

journal_title：Journal of cardiovascular pharmacology

authors： Ambrose J,Pribnow DG,Giraud GD,Perkins KD,Muldoon L,Greenberg BH

更新日期：1999-03-01 00:00:00

abstract：:Atherosclerosis is an inflammatory response to accumulation of cholesterol in the artery wall. Low-density lipoproteins (LDL) accumulate and are oxidized to proinflammatory compounds in the arterial intima during hypercholesterolemia, leading to activation of endothelial cells, macrophages, and T cells. We sought to d...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Zhou X

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The sympathetic nervous system (SNS) of the whole body, including cardiac sympathetic nerves, is activated in patients with severe congestive systolic heart failure (CHF). Carvedilol can improve clinical status in such patients. This study aimed to determine how carvedilol acts on the SNS to improve CHF. ME...

journal_title：Journal of cardiovascular pharmacology

authors： Machida M,Takechi S,Fujimoto T,Kakinoki S,Nomura A

更新日期：2012-02-01 00:00:00

abstract：:Analysis of the circadian distributions of silent ischemic episodes and myocardial infarction has revealed a circadian variability with peak event incidences in the morning hours after awakening. This morning peak of ischemic events is paralleled by circadian variations of blood pressure and heart rate that reflect an...

journal_title：Journal of cardiovascular pharmacology

authors： Kiowski W,Osswald S

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to comparatively assess the effects of irbesartan and amlodipine monotherapies on left ventricular mass index (LVMI) in patients with mild to moderate untreated hypertension and echocardiographically determined left ventricular hypertrophy (LVH). Sixty hypertensive patients (35 men, 25 women;...

journal_title：Journal of cardiovascular pharmacology

authors： Gaudio C,Ferri FM,Giovannini M,Pannarale G,Puddu PE,Vittore A,Fera MS,Vizza CD,Fedele F

更新日期：2003-11-01 00:00:00

abstract：:Rapamycin (RAPA) is an antifungal antibiotic with interesting new immunosuppressive properties. We evaluated RAPA's effects in vitro on basal and stimulated tension of isolated intact or denuded rat aortic rings. Rings were prepared in an organ chamber and contracted with 40 mM KCl (reference 100%). Some rings were tr...

journal_title：Journal of cardiovascular pharmacology

authors： Corbin F,Blaise GA,Parent M,Chen H,Daloze PM

更新日期：1994-11-01 00:00:00

abstract：:Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type 1 receptor (AT1R) mediates the established actions of angiotensin II (Ang II), and changes in its expression have been reported in cardiac fibroblasts after myocardial infarc...

journal_title：Journal of cardiovascular pharmacology

authors： Vivar R,Soto C,Copaja M,Mateluna F,Aranguiz P,Muñoz JP,Chiong M,Garcia L,Letelier A,Thomas WG,Lavandero S,Díaz-Araya G

更新日期：2008-08-01 00:00:00

abstract：:The combination of a beta-adrenoceptor-blocking drug with the dihydropyridine calcium channel antagonist, nitrendipine, has particular therapeutic advantages in the management of hypertension. The beta-blocker reduces any reflex increases in sympathetic nervous system and renin-angiotensin system activity that result ...

journal_title：Journal of cardiovascular pharmacology

authors： Mac Carthy EP

更新日期：1988-01-01 00:00:00

abstract：:Numerous studies have demonstrated that immune effector mechanisms cause serious heart diseases, among which are heart transplant rejection, myocarditis, and the resulting dilated cardiomyopathy, as well as Chagas' disease. Whereas different effectors of the immune system can affect cardiac function, this review prima...

journal_title：Journal of cardiovascular pharmacology

authors： Binah O

更新日期：2001-08-01 00:00:00

abstract：:Inotropic effects of histamine have been studied extensively in many species, but data on porcine myocardium, often used as a model for human heart, are not available. We investigated inotropic effects of histamine on atrial and ventricular trabeculae obtained from porcine hearts. For comparison, we also evaluated the...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Schoemaker RG,X462P6,Bos E,Saxena PR

更新日期：1993-09-01 00:00:00

abstract：:The aim of this study was to determine whether a quantitative relation exists between changes in regional myocardial blood flow (RMBF) and those in electrophysiologic determinants recorded via left ventricular endocardial and epicardial bipolar electrograms after administration of disopyramide (DP) and a class III ant...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe T,Iwamoto T,Iwata O,Aikawa M,Kusuzaki S,Handa S,Shinozaki Y,Mori H

更新日期：1999-08-01 00:00:00

abstract：:This study investigated the effect of pioglitazone, an insulin sensitizer, on metabolic abnormalities and oxidative stress as a cause of myocardial collagen accumulation in prediabetic rat hearts. Twenty male diabetic rats and 9 male nondiabetic age-matched rats were used. The diabetic rats were divided into two group...

journal_title：Journal of cardiovascular pharmacology

authors： Tsuji T,Mizushige K,Noma T,Murakami K,Ohmori K,Miyatake A,Kohno M

更新日期：2001-12-01 00:00:00

abstract：:Vascular endothelial cell (EC) wound healing was characterized on an EC-synthesized extracellular matrix (ECM) previously treated with enzymes and antibodies specific for ECM components. Using a computer-assisted video-microscope recording system capable of automatic EC recognition, we learned whether components of th...

journal_title：Journal of cardiovascular pharmacology

authors： Herman IM

更新日期：1993-01-01 00:00:00

abstract：:Heart failure after myocardial infarction (MI) is associated with endothelial dysfunction. There is conflicting evidence on the exact nature of this endothelial dysfunction and how endothelium-dependent vasodilation is affected by angiotensin-converting enzyme inhibitor (ACE-I) therapy. Furthermore, consequences of ac...

journal_title：Journal of cardiovascular pharmacology

authors： Westendorp B,Schoemaker RG,van Gilst WH,Buikema H

更新日期：2005-12-01 00:00:00

abstract：:In humans, three endothelin (ET) isoforms are predicted to exist by analysis of genomic DNA. However, evidence for the presence of all three mature ET peptides and their precursors remains unclear. Our aim was to identify the ET isoforms present in human heart, using radioimmunoassay (RIA) and reverse-phase high-perfo...

journal_title：Journal of cardiovascular pharmacology

authors： Plumpton C,Champeney R,Ashby MJ,Kuc RE,Davenport AP

更新日期：1993-01-01 00:00:00

abstract：:To investigate the effects of ramipril, a new angiotensin converting enzyme inhibitor, on autonomic function, autonomic function tests were performed in eight healthy male subjects, aged 22-26 years, after single oral administration of 5 mg of ramipril or placebo, in a randomized, double-blind, crossover design. Measu...

journal_title：Journal of cardiovascular pharmacology

authors： Sugimoto K,Kumagai Y,Tateishi T,Seguchi H,Ebihara A

更新日期：1989-01-01 00:00:00