Abstract:
:Recent evidence suggests that neutrophil recruitment may initiate germ cell apoptosis in the ischemic testis. The purpose of the present study was to examine the relationship between germ cell apoptosis and neutrophil recruitment in the contralateral testis following testicular ischemia-reperfusion (IR) injury in a rat. Adult male Sprague-Dawley rats were divided randomly into two experimental groups: Group A: Sham operated animals; Group B: IR rats underwent 90 min of unilateral testicular ischemia following by 96 h of reperfusion. The rats were sacrificed and testes were harvested. Johnsen's criteria and the number of germinal cell layers were measured to categorize the spermatogenesis. TUNEL assay was used to determine germ cell apoptosis in both the ischemic and contralateral testis. The recruitment of neutrophils was calculated per 100 venules. Expression of E-selectin was determined using immunohistochemical analysis. Statistical analysis was performed using Student's t test, with P less than 0.05 considered statistically significant. Germ cell apoptosis in both the ischemic and the contralateral testis increased significantly after IR. E-selectin expression was significantly greater in ischemic testis from IR rats compared to sham animals. The small increase in E-selectin expression and the concomitant increase in neutrophil recruitment in the contralateral testis of the IR rats (vs. sham animals) were not statistically significant. In conclusion, testicular ischemia causes an increase in germ cell apoptosis in the contralateral testis. Mechanisms other than neutrophil recruitment apparently initiate this process.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Sukhotnik I,Voskoboinik K,Lurie M,Coran AG,Greenblatt R,Shiloni E,Eldar S,Mogilner JGdoi
10.1007/s00383-006-1854-xsubject
Has Abstractpub_date
2007-05-01 00:00:00pages
479-85issue
5eissn
0179-0358issn
1437-9813journal_volume
23pub_type
杂志文章abstract:INTRODUCTION:Bladder Bowel Dysfunction (BBD) has been described in patients with Down's Syndrome (DS). Our aim was to report the incidence, demographics, presentation, complications and management of the bladder in DS patients with BBD. METHODS:A systematic review was performed using PRISMA guidelines and search terms...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-020-04682-4
更新日期:2020-07-01 00:00:00
abstract::The presacral cystic teratoma in an infant is reported. The cyst consisted solely of central nervous system tissue. This pathologic finding is extremely rare. A review of the literature reveals no previous report of a teratoma arising in this manner. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0831-2
更新日期:2002-12-01 00:00:00
abstract:INTRODUCTION:Objectively evaluating the lack of bowel control (fecal incontinence) continues to be a challenge. Many have attempted to measure the severity of fecal incontinence and to evaluate its impact on the quality of life by developing standardized scoring systems. Some of these systems have been validated but no...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-016-3909-y
更新日期:2016-08-01 00:00:00
abstract::The aspiration of a bronchial foreign body (FB) remains a common pediatric problem with serious and sometimes fatal sequelae. The diagnosis is often delayed or overlooked. With the aim of determining a reliable clinical and/or radiologic finding to indicate the requirement for bronchoscopy, 100 patients admitted to ou...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050080
更新日期:1997-03-21 00:00:00
abstract::This study deals with the advancement process of neuroblastoma through clinical observations and circulating tumor cell exploration. Clinical feature, tumor biology, and circulating tumor cell detected by the previously described polymerase chain reaction (PCR) method were analyzed in 31 patients with advanced neurobl...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-005-1503-9
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:We previously showed that meticulous probing and resection of the intrahepatic bile duct stenosis (IHBDS)-causing membrane or septum was effective in preventing hepatolithiasis after choledochal cyst excisions in open surgeries. Then, we introduced this maneuver into laparoscopic choledochal cyst excisions in 2...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4320-7
更新日期:2018-10-01 00:00:00
abstract::The interstitial cells of Cajal (ICC) play an important role in the control of gut motility. The recognition that the ICC cell membrane harbors the c-kit receptor (CD117) sparked rapid advancement in ICC research on the gut and certain pathologies using immunochemical and molecular methods. The question arises whether...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1314-4
更新日期:2005-03-01 00:00:00
abstract::Eighty-three gastric transpositions for oesophageal replacement were carried out over the 15-year period 1981-1995. The vast majority of patients underwent the replacement procedure for oesophageal atresia (OA) (56), 35 following failed or abandoned attempts at primary anastomosis, and 21 for isolated atresia. Caustic...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00178420
更新日期:1996-04-01 00:00:00
abstract::Endoscopic management is the accepted form of treatment for posterior urethral valves (PUV). The Nd:YAG laser has been in clinical use for many decades, but has been used only sporadically for ablating PUV. In this study, PUV were diagnosed by micturating cystourethrogram (MCU). In the 9-month period beginning March 1...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050018
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:This study evaluates the capacity of ultrasonography as a diagnostic method to confirm the proper positioning of central venous catheter (CVC) when compared to the current gold standard, chest radiography (CR). METHODS:A prospective study was performed including children from 0 to 14 incomplete years, who unde...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-020-04642-y
更新日期:2020-05-01 00:00:00
abstract::Coagulopathies associated with malignancies are not extremely rare, but are uncommonly associated with Wilms' tumour (WT). A 6-month-old female with a WT and an abnormal coagulation profile is reported. Due to the Coagulopathy and elevated D-dimers in the blood, surgery was deferred and chemotherapy was given, after w...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0853-9
更新日期:2003-06-01 00:00:00
abstract::The need for contralateral inguinal exploration in children during unilateral inguinal hernia repair remains controversial. We questioned whether an elective preoperative sonographic examination of the contralateral inguinal canal was accurate enough to prevent unnecessary exploration of the asymptotic side. Sonograph...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00180090
更新日期:1996-08-01 00:00:00
abstract:PURPOSE:Retroperitoneal teratomas (RTs) are rare among germ cell tumors and predominantly occur in infants. RTs are often difficult to manage by perioperative management. In this study, we retrospectively reviewed our series of RTs. METHODS:Seventy patients with germ cell tumors were treated from 1989 to 2015 in our i...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3938-6
更新日期:2016-09-01 00:00:00
abstract::We analyzed the causes and diagnoses, the treatment, short and long-term outcome of a consecutive series of 70 pediatric polytrauma patients. From 1989 to 1996, 70 children (aged 10 months to 16 years, mean 7.4 years) presented with multiple trauma. A follow-up investigation was performed 4.2 years (mean) after the ac...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-0954-0
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:Thoracoscopic repair can be safely performed in most types of congenital esophageal atresia (EA), including in patients with long gap EA or very low birth weight. Accordingly, we performed single- or multistage thoracoscopic repair for various EA types. We aimed to report our therapeutic strategy for thoracosco...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-019-04541-x
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:Acute respiratory distress syndrome, with the need for invasive mechanical ventilation (MV) remains a major cause of neonatal mortality and morbidity. Although venovenous extracorporeal lung support (VV-ECLS) has become a standard of care procedure in neonatal patients with acute pulmonary failure there are no ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3815-8
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Sacrococcygeal teratoma (SCT) is a rare childhood malignancy. Although overall survival is favorable, recurrent tumors are associated with poor outcomes. As most recurrences occur within 3 years of presentation, the utility of long-term surveillance is uncertain. METHODS:Patients with SCTs evaluated and man...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4132-1
更新日期:2017-11-01 00:00:00
abstract::Multiple endocrine neoplasia (MEN) 2B is a hereditary syndrome including medullary thyroid carcinoma (MTC), pheochromocytoma, gastrointestinal (GI) disorders, marfanoid facies, and multiple ganglioneuromas. MTC is the major cause of mortality, and often appears during the 1st decade of life. RET proto-oncogene mutatio...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0824-1
更新日期:2002-09-01 00:00:00
abstract::Fetal skin wounds heal scarlessly while adult wounds scar. Fetal wound healing occurs in a physiologically hypoxic environment whereas in adult wound healing, cells have to acutely adapt to hypoxia caused by locally impaired blood supply. We examined the expression of hypoxia-inducible factor 1 (HIF-1), a potent trans...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050735
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:Tracheoesophageal fistula (TEF) is a bellwether for a country's ability to care for sick newborns. We aim to review the existing literature from low- and middle-income countries in regard to management of those newborns and the possible approaches to improve their outcomes. METHODS:A review of the existing Eng...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-020-04639-7
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Although the precise pathogenesis of ventral body wall (VBW) defects is not clearly understood, it has recently postulated that disruption of somite development during early embryogenesis may cause failure of proper VBW formation. The administration of cadmium (Cd) after 60 h of incubation induces omphalocele s...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-011-2994-1
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:We sought to determine the incidence and timing of testicular atrophy following inguinal hernia repair in children. METHODS:We used the TRICARE database, which tracks care delivered to active and retired members of the US Armed Forces and their dependents, including > 3 million children. We abstracted data on ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4255-z
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:Diagnosis of imperforate anus is usually made shortly after birth with physical examination. Nonetheless, a significant number of patients have presented beyond the neonatal period without recognition of anorectal malformation. We reviewed our experience of anorectal malformations, with particular emphasis on t...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2691-5
更新日期:2010-11-01 00:00:00
abstract::An infant developed massive lower gastrointestinal haemorrhage secondary to necrotising enterocolitis after cardiac surgery. The haemorrhage was only controlled following a colectomy. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050613
更新日期:1999-07-01 00:00:00
abstract::Congenital lung lesions are diagnosed antenatally in the majority of cases. Postnatal management includes chest radiography and CT-scanning, followed by either surgical resection or CT surveillance. Pre-operatively, lesions are often "labelled" as CCAM (and the Stocker classification incorrectly applied), sequestratio...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2201-1
更新日期:2008-09-01 00:00:00
abstract::In neonates requiring operation for necrotizing enterocolitis (NEC), the complications due to enterostomy (ES) and the need for another operation to restore continuity have prompted several surgeons to employ primary anastomosis (PA) after resection as the operative strategy of choice. Our objective was to compare pri...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-017-4126-z
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To describe the association of anorectal malformation (ARM) and spinal dysraphism (SD) in terms of impact on the management of SD and embryogenetic implications. METHODS:Patients with SD associated with (A) or without (B) ARM were included. The two groups were further divided into operated on (A1/B1) or not (A...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4104-5
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The natural history of patients with antenatally diagnosed congenital cystic adenomatoid malformation of the lung (CCAM) is still fully unknown. In symptomatic patients with respiratory distress, an operation is performed during the neonatal period. However, in asymptomatic patients, the optimal timing of th...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2431-x
更新日期:2009-09-01 00:00:00
abstract::In the published version, the Acknowledgements section was missing a funding note of co-author Dr C Verrill. The corrected version should read as follows. ...
journal_title:Pediatric surgery international
pub_type: 已发布勘误
doi:10.1007/s00383-020-04624-0
更新日期:2020-04-01 00:00:00
abstract::Hirschsprung disease is the result of aganglionosis of a variable length of the terminal bowel, which arises from the incomplete colonisation of the embryonic gut by vagal neural crest-derived cells (NCC) that migrate caudally from the pharyngeal gut to the rectum. We have previously shown that a very small group of N...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0868-2
更新日期:2002-10-01 00:00:00