Abstract：
INTRODUCTION:Bladder Bowel Dysfunction (BBD) has been described in patients with Down's Syndrome (DS). Our aim was to report the incidence, demographics, presentation, complications and management of the bladder in DS patients with BBD. METHODS:A systematic review was performed using PRISMA guidelines and search terms "{[(trisomy 21) OR down's syndrome]} AND [("non-neurogenic") OR voiding dysfunction]" in the search engines MEDLINE and SCOPUS. We also include a case series from two paediatric urology centres. RESULTS:A total of 38 patients with BBD and DS were included. Mean age was 12 years (newborn to 21 years), the male:female ratio was 2:1. Functional constipation (90%), recurrent urinary tract infections (38%) and enuresis were common at presentation (56%), while over 56% patients required surgical intervention. Medical treatment and behavioral modification were less successful while intermittent catheterisation did not work. CONCLUSION:This study reviews the largest cohort of patients with BBD in DS. It is common with serious consequences requiring operative intervention. Usual interventions are unreliable due to poor compliance. Early identification and management protect the renal tract. Regular screening for urogenital anomalies in DS is currently not performed. We recommend a thorough history of bladder function in DS patients to identify these cases early.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Bhatt NR,Murchison L,Yardy G,Kulkarni M,Mathur ABdoi
10.1007/s00383-020-04682-4subject
Has Abstractpub_date
2020-07-01 00:00:00pages
763-772issue
7eissn
0179-0358issn
1437-9813pii
10.1007/s00383-020-04682-4journal_volume
36pub_type
杂志文章abstract：PURPOSE:Chronological age has not always been an accurate predictor of gut motility in newborns. We hypothesized that the enteric plexus is immature at birth. We studied whole-mount preparations of the myenteric plexus in pigs from mid-point of gestation to adulthood. METHODS:Distal large bowel whole-mount preparation...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2265-y
更新日期：2008-12-01 00:00:00
abstract：:Retrocaval ureter is a relatively rare anomaly that usually manifests in the third or fourth decades. Symptoms are due to ureteric obstruction, either extrinsic by the abnormal inferior vena cava (IVC), or intrinsic ureteric hypoplasia. Surgery is needed for symptomatic cases and involves transection and relocation of...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1038-x
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:Although Rex shunt is an effective treatment for extrahepatic portal venous obstruction (EHPVO), 4-20% children develop rebleeding postoperatively. This study was used to evaluate the surgical treatment of rebleeding after Rex shunt in our center. METHOD:From June 2008 to Jan 2017, 12 of 122 children with EHPV...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4246-0
更新日期：2018-05-01 00:00:00
abstract：:Clear cell sarcoma of the kidney (CCSK) is an uncommon neoplasm that accounts for almost 3 % of pediatric renal tumors. Cavoatrial tumor thrombosis is very rare and because of poor response to chemotherapy, invasive surgical interventions such as open heart surgery may be indicated. A 6-year-old girl with CCSK of righ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3160-0
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Cervicovaginal atresia is a rare Mullerian anomaly. The management of cervicovaginal atresia has evolved from historical recommendations of hysterectomy to various reconstructive procedures more recently. The latter carries a risk of significant morbidity and unknown fertility. We present our experience in t...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3550-6
更新日期：2014-10-01 00:00:00
abstract：:The presacral cystic teratoma in an infant is reported. The cyst consisted solely of central nervous system tissue. This pathologic finding is extremely rare. A review of the literature reveals no previous report of a teratoma arising in this manner. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0831-2
更新日期：2002-12-01 00:00:00
abstract：:The most popular techniques for repairing large diaphragmatic defects involve the use of synthetic patches. We present an alternative approach using living tissue. We reviewed our cases of congenital diaphragmatic hernia (CDH) diagnosed within the first 24 h of life from 1991 to 2003. Toldt's fascia (TF) flap was used...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1267-7
更新日期：2005-01-01 00:00:00
abstract：:Peri-catheter calcification is an unusual and previously unreported complication of central venous (CV) catheterization in infants. A 1. 9 Fr Silastic CV catheter was placed in a term infant for administration of total parenteral nutrition and antibiotics following intra-abdominal sepsis. The catheter was removed, wit...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050418
更新日期：1998-10-01 00:00:00
abstract：:The embryogenesis of a previously unreported mesothelial pouch containing a Meckel's diverticulum is presented. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01076960
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:The purpose of this study was to test the susceptibility of human hepatoblastoma and neuroblastoma cells to photodynamic diagnostics (PDD) and photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) as a photosensitizer. METHODS:Cell cultures of human hepatoblastoma (HuH6) and neuroblastoma (MHH-NB-11) ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2275-9
更新日期：2008-12-01 00:00:00
abstract：:Gastroschisis closure is performed either primarily or after staged reduction of the prolapsed bowel. A technique for surgical closure of the abdominal wall defect is described which allows for an almost scarless appearance of the abdominal surface with preservation of a midline umbilicus. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2215-8
更新日期：2008-09-01 00:00:00
abstract：:Complete transposition of the penis and scrotum, or prepenile scrotum, is an uncommon congenital malformation. Concomitant genitourinary abnormalities, often life-threatening in nature, are frequently seen, and major malformations involving other organ systems may also be present. We report a newborn in whom complete ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050650
更新日期：1999-01-01 00:00:00
abstract：:Recently, most studies reported magnesium as a N-methyl-D-aspartate receptor antagonist and its analgesic and perioperative anaesthetic effects have been discussed with central desensitization pathway. We investigated the effects of caudal ropivacaine plus magnesium and compared with ropivacaine alone on postoperative...
journal_title：Pediatric surgery international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00383-006-1779-4
更新日期：2007-02-01 00:00:00
abstract：:The confluence of the right and left hepatic ducts at the hepatic hilum frequently shows normal anatomic variations. Choledochal cysts (CC) are also accompanied by similar variations, and devices for free drainage of bile are occasionally required in biliary reconstruction. We present a CC that had an aberrant posteri...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01371914
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:Since 1999, complete primary repair of exstrophy has represented a valid alternative in the treatment of exstrophy patients, offering one- stage reconstruction for all components of this malformation in newborns. The vast majority of cases are currently approached within 48/72 h of life, and risk of vascular in...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2745-8
更新日期：2011-04-01 00:00:00
abstract：:Extrarenal malignant rhabdoid tumour is a rare neoplasm of childhood. A congenital example has only been reported once previously, presenting as a facial mass. We report a second congenital case with the tumour over the right shoulder in which postoperative investigations revealed multiple hepatic metastases proving f...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00497837
更新日期：1996-06-01 00:00:00
abstract：PURPOSE:In 2006, The Japanese Society of Pediatric Endoscopic Surgeons devised a plan to develop a pediatric endoscopic surgical skill qualification (ESSQ) system. This system is controlled by The Japan Society for Endoscopic Surgery. The standard requirement for skills qualification is the ability of each applicant to...
journal_title：Pediatric surgery international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00383-011-2871-y
更新日期：2011-07-01 00:00:00
abstract：:We review a single surgeon and surgical centre's experience with congenital cystic adenomatoid malformation of the lung (CCAML) in relation to clinical spectrum, operative experience, and postoperative course. A retrospective hospital record review was done on surgically treated cases of CCAML over a 10-year period, f...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1225-4
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:To study the gender assignment and hormonal treatment advocated for disorders of sexual differentiation (DSD). METHODS:A study was done on patients who were reviewed in the Pediatric Intersex Clinic to evaluate the pattern of gender assignment and hormonal treatment advocated. RESULTS AND CONCLUSION:The patie...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2232-7
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVES:Both aquaporin (AQP) 1 and the stem-cell factor/C-kit system seem to have a definite role in testis function, but very few studies have been reported in humans, especially in the paediatric age group. With the present study we wanted to investigate the expression of these proteins to better delineate their r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1125-z
更新日期：2004-04-01 00:00:00
abstract：:A retrospective study of all cases (n = 21) of congenital lobar emphysema (CLE) treated at the Royal Hospital, Muscat, from September 1988 to August 1999 was performed. The presentation, diagnosis, treatment, and outcome are reviewed. All 21 patients were nonwhite. Thirteen had left-upper-lobe, 7 right-middle-lobe, an...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000506
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Sacrococcygeal teratoma (SCT) is a rare childhood malignancy. Although overall survival is favorable, recurrent tumors are associated with poor outcomes. As most recurrences occur within 3 years of presentation, the utility of long-term surveillance is uncertain. METHODS:Patients with SCTs evaluated and man...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4132-1
更新日期：2017-11-01 00:00:00
abstract：:An experimental study was conducted to determine the end-results of two different defects on the anterior abdominal wall: an abdominal wall defect (AWD) versus an umbilical cord defect (UCD) using chick embryos. The AWD was created by leaving an intact skin bridge between the defect and the umbilical cord in group 1; ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01371904
更新日期：1997-01-01 00:00:00
abstract：:Measurement of testicular volume is a more readily available method of estimating spermatogenesis in adolescence. Traditionally, testicular volumes have been measured with different type of orchidometers or calipers. The most widely used orchidometer is the Prader orchidometer introduced in 1966. This type of orchidom...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1470-1
更新日期：2005-07-01 00:00:00
abstract：:True duplicate exstrophy is a rare and interesting congenital anomaly. We are adding a case to the previously reported seven cases in the world literature. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830000557
更新日期：2002-03-01 00:00:00
abstract：:Pediatric germ cell tumors comprise 1-3% of all malignant pediatric tumors and are found in variable locations. We present the case of a term 3.7 kg neonate who was found to have a giant liver mass at birth, later determined to be an immature teratoma arising from the hepatoduodenal ligament. This case report and imag...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4123-2
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:We previously showed that meticulous probing and resection of the intrahepatic bile duct stenosis (IHBDS)-causing membrane or septum was effective in preventing hepatolithiasis after choledochal cyst excisions in open surgeries. Then, we introduced this maneuver into laparoscopic choledochal cyst excisions in 2...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4320-7
更新日期：2018-10-01 00:00:00
abstract：:New development in the vascular network is a significant process for the proliferation, as well as metastatic expand, of cancer cells that depends on a sufficient provider of oxygen and nutrients and the removal of waste products. New blood and lymphatic vessels form via step called angiogenesis and lymphangiogenesis....
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3398-1
更新日期：2013-12-01 00:00:00
abstract：UNLABELLED:Necrotizing enterocolitis (NEC) is a serious condition with a high morbidity and mortality commonly affecting premature babies. Data for the impact of the long-term disease burden in developing countries are limited although poor long-term outcome of surgically managed patients has been shown in terms of inc...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2583-8
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:There is a shortage of surgeons in Africa, and this shortage is particularly acute in paediatric surgery with most paediatric patients being cared for by general surgeons. The use of information technology to augment teaching in paediatric surgery in Africa is appealing but often unsuccessful due to the cost...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2806-z
更新日期：2011-04-01 00:00:00
