Abstract:
BACKGROUND:In Saudi Arabia, the epidemiology and clinical significance of Torque Teno virus (TTV) infection alone and in patients with hepatitis virus infections have not been determined in a single study. In this paper, we molecularly investigated the rate and genotypes of TTV infection among Saudi Arabian blood donors and patients with viral hepatitis. The effect of TTV coinfection on viral hepatitis was also examined. SUBJECTS AND METHODS:DNA was extracted from the sera of 200 healthy blood volunteers, 45 hepatitis B virus patients, 100 hepatitis C virus patients, 19 hepatitis G virus patients, and 56 non-A-G hepatitis patients. TTV DNA was amplified using primers derived from the ORF1 and 5'UTR regions. The alanine aminotransferase (ALT) level was determined for each specimen. Sequencing of ORF1 amplicons was carried out to investigate TTV genotypes. RESULTS:Using primers derived from ORF1 and 5'UTR, TTV DNA was detected in 5.5% and 50.5%, respectively, of healthy blood donors, in 2.2% and 88.8% in hepatitis B patients, in 2.0% and 70% of hepatitis C patients, in 15.8% and 100% of hepatitis G patients, in 5.4% and 12.5% of non-A-G hepatitis patients and in 4.8% and 56.4% overall. No detrimental effect of TTV coinfection in viral hepatitis patients was noted. An overall prevalence of 4.8% and 56.4% was established. Phylogenetic analysis indicated that the most common genotype of TTV among Saudis is 2c. CONCLUSION:The rate of TTV infection among Saudi Arabians seems to be lower than that stated in previous reports on Saudi Arabia and in some other countries. The virus does not seem to worsen the status of those who are suffering from viral hepatitis infection.
journal_name
Ann Saudi Medjournal_title
Annals of Saudi medicineauthors
Al-Mozaini MA,Al-Ahdal MN,Kessie G,Dela Cruz DM,Rezeig MA,Al-Shammary FJdoi
10.5144/0256-4947.2006.444subject
Has Abstractpub_date
2006-11-01 00:00:00pages
444-9issue
6eissn
0256-4947issn
0975-4466pii
06-189journal_volume
26pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The current practice in Zagazig University Hospitals Laboratories (ZUHL) is manual verification of all results for the later release of reports. These processes are time consuming and tedious, with large inter-individual variation that slows the turnaround time (TAT). Autoverification is the p...
journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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journal_title:Annals of Saudi medicine
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doi:10.5144/0256-4947.1992.391
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
doi:10.5144/0256-4947.1992.178
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pub_type: 杂志文章
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journal_title:Annals of Saudi medicine
pub_type: 杂志文章
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