Pathophysiologic mechanisms responsible for the reversible (thiamine-responsive) and irreversible (thiamine non-responsive) neurological symptoms of Wernicke's encephalopathy.

Abstract:

:Chronic alcoholism results in thiamine deficiency as a result of poor nutrition and impaired gastrointestinal absorption of the vitamin. Pyrithiamine-induced thiamine deficiency in the rat reproduces a neurological syndrome and ultimately neuropathological damage of a nature and distribution that is similar to that encountered in Wernicke's encephalopathy in humans. Pyrithiamine-induced thiamine deficiency results in selective reversible decreases in activity of the thiamine-dependent enzyme alpha-ketoglutarate dehydrogenase and concomitant reversible changes in brain amino acids. It is proposed that these changes constitute "the biochemical lesion" in thiamine deficiency encephalopathy. If sufficiently severe and prolonged, decreased activities of alpha-ketoglutarate dehydrogenase may result in compromised brain energy metabolism and in lactate accumulation in brain, both of which could be responsible for neuronal cell death in this condition. In addition, it has been suggested that cell death results from NMDA-receptor mediated excitotoxic damage. Similar pathophysiologic mechanisms could be responsible for brain cell death in Wernicke's encephalopathy in humans.

journal_name

Drug Alcohol Rev

journal_title

Drug and alcohol review

authors

Butterworth RF

doi

10.1080/09595239300185371

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

315-22

issue

3

eissn

0959-5236

issn

1465-3362

pii

H8127422K8617647

journal_volume

12

pub_type

杂志文章
  • Does parental monitoring and disapproval explain variations in alcohol use among adolescents from different countries of birth?

    abstract:INTRODUCTION AND AIMS:This study investigated the extent to which parental monitoring and parental disapproval of alcohol use account for the association between country of birth and adolescent alcohol use. DESIGN AND METHODS:The sample consisted of 10 273 adolescents from grades 7 (Mean age = 12.5 years), 9 (14.5 yea...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.12413

    authors: Chan GC,Kelly AB,Connor JP,Hall WD,Young RM,Williams JW

    更新日期:2016-11-01 00:00:00

  • Groin tissue necrosis requiring skin graft following parenteral abuse of buprenorphine tablets.

    abstract::In May 2002 Buprenorphine (Subutex) was listed on the Australian Pharmaceutical Benefits Schedule for treatment in opioid dependence. In addition to broadening treatment options, buprenorphine has the advantage of an improved safety profile. The risk of overdose is lessened but other risks remain due to diversion. Fre...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/0959523031000154508

    authors: Feeney GF,Fairweather P

    更新日期:2003-09-01 00:00:00

  • A brief motivational intervention for substance misuse in recent-onset psychosis.

    abstract::Substance misuse is common in early psychosis, and impacts negatively on outcomes. Little is known about effective interventions for this population. We report a pilot study of brief intervention for substance misuse in early psychosis (Start Over and Survive: SOS), comparing it with Standard Care (SC). Twenty-five in...

    journal_title:Drug and alcohol review

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/09595230410001704127

    authors: Kavanagh DJ,Young R,White A,Saunders JB,Wallis J,Shockley N,Jenner L,Clair A

    更新日期:2004-06-01 00:00:00

  • Alcohol and tobacco co-use in nondaily smokers: an inevitable phenomenon?

    abstract:INTRODUCTION AND AIMS:Alcohol use has consistently been associated with smoking among nondaily smokers. However, this may not be an inevitable relationship that extends across all drinking sessions and/or all nondaily smokers. Recently, distinct subgroups of nondaily smokers have been identified, with one subgroup main...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2011.00328.x

    authors: Campbell ML,Bozec LJ,McGrath D,Barrett SP

    更新日期:2012-06-01 00:00:00

  • Risky drug practices and treatment needs of youth detained in New South Wales Juvenile Justice Centres.

    abstract::Demographic, drug use and criminal correlates of risky drug practices were examined among 279 detained youth in NSW Juvenile Justice Centres. Binge drinking was common, with 63% reporting the consumption of at least five drinks in a row in the 2 weeks prior to incarceration. It was associated with being older, being f...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/09595239700186431

    authors: Hando J,Howard J,Zibert E

    更新日期:1997-06-01 00:00:00

  • An examination of the extent to which drinking motives and problem alcohol consumption vary as a function of deprivation, gender and age.

    abstract:INTRODUCTION:Existing research points to a link between socioeconomic factors, alcohol consumption and harms, while another body of work documents the importance of varying motivations to drink in shaping alcohol behaviours. Yet, little is currently known about the extent to which alcohol consumption may be differentia...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.13221

    authors: Heim D,Monk RL,Qureshi AW

    更新日期:2020-11-26 00:00:00

  • Factors associated with antenatal smoking among Aboriginal and Torres Strait Islander women in two jurisdictions.

    abstract:INTRODUCTION AND AIMS:Smoking rates are three times as high for pregnant Indigenous women relative to non-Indigenous women, in Australia. This paper describes Indigenous women's self-reported antenatal smoking behaviour and compares knowledge and attitudes of those who: (i) smoke and don't smoke during pregnancy; and (...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2012.00448.x

    authors: Passey ME,D'Este CA,Stirling JM,Sanson-Fisher RW

    更新日期:2012-07-01 00:00:00

  • Implementing a smoking cessation program in social and community service organisations: a feasibility and acceptability trial.

    abstract:INTRODUCTION AND AIMS:Novel ways of accessing and engaging smokers who are socially and economically disadvantaged may help reduce socioeconomic disparities in smoking rates. This study assessed the feasibility and acceptability of integrating smoking cessation support into usual care at a social and community service ...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2011.00391.x

    authors: Bryant J,Bonevski B,Paul C,Hull P,O'Brien J

    更新日期:2012-07-01 00:00:00

  • The prevalence and correlates of secondary traumatic stress among alcohol and other drug workers in Australia.

    abstract:INTRODUCTION AND AIMS:The high prevalence of trauma exposure and post-traumatic stress disorder (PTSD) among clients of alcohol and other drug (AOD) services is well documented. Less is known, however, about the impact this has on workers who assess and treat such clients. The aim of this study was to examine the preva...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.12204

    authors: Ewer PL,Teesson M,Sannibale C,Roche A,Mills KL

    更新日期:2015-05-01 00:00:00

  • The monitoring of drug trends in Australia.

    abstract::Recently, there has been increased recognition of the importance of drug information systems (DIS), highlighting the need for an internationally coordinated approach to data collection and advocating the regular assessment of a range of areas. Accurate information provides policy makers with the evidence to evaluate c...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章,评审

    doi:10.1080/0959523021000059848

    authors: Shand F,Topp L,Darke S,Makkai T,Griffiths P

    更新日期:2003-03-01 00:00:00

  • Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment.

    abstract:INTRODUCTION AND AIMS:Cigarette smoking occurs frequently among individuals with methamphetamine (MA) dependence. Preclinical and clinical evidence has suggested that the common co-abuse of MA and cigarettes represents a pharmacologically meaningful pattern. METHODS:The present study is a secondary analysis of a rando...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1465-3362.2012.00423.x

    authors: Brensilver M,Heinzerling KG,Swanson AN,Telesca D,Furst BA,Shoptaw SJ

    更新日期:2013-01-01 00:00:00

  • The nature and strength of the relationship between expenditure on alcohol and food: an analysis of adult-only households in the UK.

    abstract:INTRODUCTION AND AIMS:Unhealthy lifestyle behaviours can cluster to produce more detrimental overall health consequences than expected with a simple additive effect. This study aims to expand current knowledge of the nature and strength of the relationship between two such health behaviours, alcohol and diet, through a...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2011.00330.x

    authors: Gell L,Meier P

    更新日期:2012-06-01 00:00:00

  • Alcohol use of immigrant youths in The Netherlands: The roles of parents and peers across different ethnic backgrounds.

    abstract:INTRODUCTION AND AIMS:The aims of this study were to examine the roles of parental permissiveness toward alcohol use and affiliation with alcohol-using peers in alcohol use in youths from various ethnic backgrounds, and whether the role of peers was moderated by parental permissiveness. In addition, differences in thes...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.12555

    authors: Creemers HE,Spanakis P,Delforterie MJ,Huizink AC

    更新日期:2017-11-01 00:00:00

  • An evaluation of a pilot capacity building initiative for smoking cessation in social and community services: the Smoking Care project.

    abstract:INTRODUCTION AND AIMS:New strategies are required to reach subpopulations with high smoking rates. This study reports on an evaluation of the Smoking Care intervention-a 2-year organisational capacity building strategy--for social and community service organisations (SCSOs) to provide smoking care to clients. DESIGN A...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2012.00464.x

    authors: O'Brien J,Bonevski B,Salmon A,Oakes W,Goodger B,Soewido D

    更新日期:2012-07-01 00:00:00

  • Young people and gambling content in social media: An experimental insight.

    abstract:INTRODUCTION AND AIMS:Online gambling advertising and user-generated gambling content have increased. This study used a social psychological online experiment to analyse young people's reactions towards and self-reported interests in social media gambling messages. DESIGN AND METHODS:A vignette experiment with a two-l...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.13010

    authors: Kaakinen M,Sirola A,Savolainen I,Oksanen A

    更新日期:2020-02-01 00:00:00

  • Potential impacts on the incidence of fatal heroin-related overdose in Western Australia: a time-series analysis.

    abstract::In response to the rising concerns about the rate of heroin-related fatalities, overdose prevention campaigns, run by both users' organizations and government agencies, have been implemented in a number of states across Australia. In Western Australia (WA) in mid-1997, various overdose prevention initiatives were impl...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/0959523021000023162

    authors: Hargreaves K,Lenton S,Phillips M,Swensen G

    更新日期:2002-12-01 00:00:00

  • Consumption and advertising of alcoholic beverages in Australia, 1969-86.

    abstract::The objective of the study was to examine the relationship between alcohol consumption per adult (>/=15 years old) and expenditure on alcohol advertising per adult in Australia for the 18 years from 1969 to 1986. In addition, analyses were made of the extent to which annual changes in consumption were related to annua...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/09595239000185051

    authors: Smith DI

    更新日期:1990-01-01 00:00:00

  • Gender differences in adolescents attending a drug and alcohol withdrawal service.

    abstract:INTRODUCTION AND AIMS:Gender differences have been reported in adult substance users, but little research has examined gender differences in adolescents presenting to treatment services. This study aimed to explore gender differences in adolescents presenting to a withdrawal service. DESIGN AND METHODS:All presentatio...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2009.00152.x

    authors: Dean AJ,McBride M,Macdonald EM,Connolly Y,McDermott BM

    更新日期:2010-05-01 00:00:00

  • Barriers and missed opportunities to HIV testing among injection drug users in two Mexico--US border cities.

    abstract:INTRODUCTION AND AIMS:Despite increasing HIV prevalence in cities along the Mexico--US border, HIV testing among high-risk populations remains low. We sought to identify barriers associated with HIV testing among injection drug users (IDUs) in Tijuana and Ciudad Juarez, the two largest Mexican border cities located acr...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/09595230701710845

    authors: Moyer LB,Brouwer KC,Brodine SK,Ramos R,Lozada R,Cruz MF,Magis-Rodriguez C,Strathdee SA

    更新日期:2008-01-01 00:00:00

  • Assessing the accuracy of self-reported smoking status and impact of passive smoke exposure among pregnant Aboriginal and Torres Strait Islander women using cotinine biochemical validation.

    abstract:INTRODUCTION AND AIMS:A significant level of misreport or error occurs during questionnaire-based assessment of smoking behaviour. Failure to measure environmental tobacco smoke, and participant's inclination to under-report their smoking raise questions as to the accuracy of assessment. In order to establish an estima...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2009.00078.x

    authors: Gilligan C,Sanson-Fisher R,Eades S,Wenitong M,Panaretto K,D'Este C

    更新日期:2010-01-01 00:00:00

  • Becoming an ex-user: insights into the process and implications for treatment and policy.

    abstract::Studies of the processes by which people give up dependent heroin use are useful in helping services evaluate their treatment practices and in informing drug policy debates. In this exploratory investigation, a diverse group of 18 Canberra-based ex-users was interviewed about stopping, the role of treatment and their ...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/09595239400185381

    authors: Bammer G,Weekes S

    更新日期:1994-01-01 00:00:00

  • Pharmacists on the front line in providing support for nicotine replacement therapy and bupropion purchasers.

    abstract:INTRODUCTION AND AIMS:Increased access for smokers to pharmacotherapies for smoking cessation suggests that pharmacists have a potential role in influencing how these pharmacotherapies are used in the community. This study aimed to identify the extent and type of advice provided by pharmacists to customers purchasing n...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/09595230701373966

    authors: Paul CL,Tzelepis F,Walsh RA,Turner R

    更新日期:2007-07-01 00:00:00

  • 'Weekend on the town': discrete sessions of drug use for a sample of young psychostimulant users.

    abstract:INTRODUCTION AND AIMS:Few epidemiological studies have examined the behaviours and experiences of young adults during discrete drug-use events. This study was designed to capture a rich, detailed description of discrete occasions or 'sessions' of psychostimulant use. DESIGN AND METHODS:Participants were 220 young psyc...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.12168

    authors: Jenkinson R,Jolley D,Dietze P

    更新日期:2014-07-01 00:00:00

  • Developmental trajectories of illicit drug use, prescription drug misuse and cannabis practices among young adult cannabis users in Los Angeles.

    abstract:INTRODUCTION AND AIMS:Young adults have the highest rates of drug use and contribute significantly to the growing population of medical cannabis patients (MCP). This study examined relationships between longitudinal patterns of illicit/prescription drug use/misuse and cannabis practices among young adult cannabis users...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.13078

    authors: Fedorova EV,Schrager SM,Robinson LF,Roth AM,Wong CF,Iverson E,Lankenau SE

    更新日期:2020-09-01 00:00:00

  • Expanding knowledge among Aboriginal service providers on treatment options for excessive alcohol use.

    abstract::Approaches to the prevention of alcohol problems among Aboriginal people in Australia have tended to emphasize primary and tertiary prevention, while neglecting secondary prevention or early intervention. In contrast, members of the wider Australian community can now access a variety of early interventions through gen...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/09595239800187611

    authors: Brady M,Dawe S,Richmond R

    更新日期:1998-03-01 00:00:00

  • Association between concurrent alcohol and tobacco use and poverty.

    abstract:INTRODUCTION AND AIMS:The harm from alcohol and tobacco use in low- and middle-income countries includes substantial economic cost to the individual. Our aim was to describe the expenditure on concurrent alcohol and tobacco use in relation to family income in two districts in Sri Lanka. DESIGN AND METHODS:A community-...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2010.00202.x

    authors: de Silva V,Samarasinghe D,Hanwella R

    更新日期:2011-01-01 00:00:00

  • Health and well-being outcomes for drug-dependent offenders on the NSW Drug Court programme.

    abstract::Given the centrality of drug treatment to the drug court framework, the proliferation of drug courts in the United States, and their emergence more recently in Australia, it is surprising that such little attention has been given to assessing their therapeutic effect. This evaluation aimed to assess the health and wel...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1080/09595230310001613921

    authors: Freeman K

    更新日期:2003-12-01 00:00:00

  • The use of drug detection dogs in Sydney, Australia.

    abstract:INTRODUCTION AND AIMS:At present there is little research into the use of drug detection dogs. The present study sought to explore the use of detection dogs in Sydney, Australia, utilising multiple data sources. DESIGN AND METHODS; Data were taken from interviews with 100 regular ecstasy users and 20 key experts as par...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/j.1465-3362.2009.00065.x

    authors: Dunn M,Degenhardt L

    更新日期:2009-11-01 00:00:00

  • One explanation to rule them all? Identifying sub-groups of non-drinking Swedish ninth graders.

    abstract:INTRODUCTION AND AIMS:Researchers in a number of countries have recently identified major changes in adolescent alcohol consumption since the early 2000s, with the prevalence of teenage drinking more than halving in some countries. The major aims of the current study are to examine if there are sub-groups among non-dri...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.12663

    authors: Raninen J,Livingston M,Karlsson P,Leifman H,Guttormsson U,Svensson J,Larm P

    更新日期:2018-04-01 00:00:00

  • What factors are associated with abstinence amongst socioeconomically disadvantaged smokers? A cross-sectional survey of use of cessation aids and quitting approach.

    abstract:INTRODUCTION AND AIMS:This study aimed to compare current and ex-smokers' sociodemographic and psychosocial characteristics, use of cessation aids and abrupt versus gradual quitting approaches. DESIGN AND METHODS:A cross-sectional survey of financially disadvantaged adults attending a community service organisation wa...

    journal_title:Drug and alcohol review

    pub_type: 杂志文章

    doi:10.1111/dar.12561

    authors: Twyman L,Bonevski B,Paul C,Bryant J,West R,Siahpush M,D'este C,Oldmeadow C,Palazzi K

    更新日期:2018-02-01 00:00:00