Abstract:
:Chronic alcoholism results in thiamine deficiency as a result of poor nutrition and impaired gastrointestinal absorption of the vitamin. Pyrithiamine-induced thiamine deficiency in the rat reproduces a neurological syndrome and ultimately neuropathological damage of a nature and distribution that is similar to that encountered in Wernicke's encephalopathy in humans. Pyrithiamine-induced thiamine deficiency results in selective reversible decreases in activity of the thiamine-dependent enzyme alpha-ketoglutarate dehydrogenase and concomitant reversible changes in brain amino acids. It is proposed that these changes constitute "the biochemical lesion" in thiamine deficiency encephalopathy. If sufficiently severe and prolonged, decreased activities of alpha-ketoglutarate dehydrogenase may result in compromised brain energy metabolism and in lactate accumulation in brain, both of which could be responsible for neuronal cell death in this condition. In addition, it has been suggested that cell death results from NMDA-receptor mediated excitotoxic damage. Similar pathophysiologic mechanisms could be responsible for brain cell death in Wernicke's encephalopathy in humans.
journal_name
Drug Alcohol Revjournal_title
Drug and alcohol reviewauthors
Butterworth RFdoi
10.1080/09595239300185371subject
Has Abstractpub_date
1993-01-01 00:00:00pages
315-22issue
3eissn
0959-5236issn
1465-3362pii
H8127422K8617647journal_volume
12pub_type
杂志文章abstract:INTRODUCTION AND AIMS:This study investigated the extent to which parental monitoring and parental disapproval of alcohol use account for the association between country of birth and adolescent alcohol use. DESIGN AND METHODS:The sample consisted of 10 273 adolescents from grades 7 (Mean age = 12.5 years), 9 (14.5 yea...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12413
更新日期:2016-11-01 00:00:00
abstract::In May 2002 Buprenorphine (Subutex) was listed on the Australian Pharmaceutical Benefits Schedule for treatment in opioid dependence. In addition to broadening treatment options, buprenorphine has the advantage of an improved safety profile. The risk of overdose is lessened but other risks remain due to diversion. Fre...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/0959523031000154508
更新日期:2003-09-01 00:00:00
abstract::Substance misuse is common in early psychosis, and impacts negatively on outcomes. Little is known about effective interventions for this population. We report a pilot study of brief intervention for substance misuse in early psychosis (Start Over and Survive: SOS), comparing it with Standard Care (SC). Twenty-five in...
journal_title:Drug and alcohol review
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/09595230410001704127
更新日期:2004-06-01 00:00:00
abstract:INTRODUCTION AND AIMS:Alcohol use has consistently been associated with smoking among nondaily smokers. However, this may not be an inevitable relationship that extends across all drinking sessions and/or all nondaily smokers. Recently, distinct subgroups of nondaily smokers have been identified, with one subgroup main...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2011.00328.x
更新日期:2012-06-01 00:00:00
abstract::Demographic, drug use and criminal correlates of risky drug practices were examined among 279 detained youth in NSW Juvenile Justice Centres. Binge drinking was common, with 63% reporting the consumption of at least five drinks in a row in the 2 weeks prior to incarceration. It was associated with being older, being f...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595239700186431
更新日期:1997-06-01 00:00:00
abstract:INTRODUCTION:Existing research points to a link between socioeconomic factors, alcohol consumption and harms, while another body of work documents the importance of varying motivations to drink in shaping alcohol behaviours. Yet, little is currently known about the extent to which alcohol consumption may be differentia...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.13221
更新日期:2020-11-26 00:00:00
abstract:INTRODUCTION AND AIMS:Smoking rates are three times as high for pregnant Indigenous women relative to non-Indigenous women, in Australia. This paper describes Indigenous women's self-reported antenatal smoking behaviour and compares knowledge and attitudes of those who: (i) smoke and don't smoke during pregnancy; and (...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2012.00448.x
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION AND AIMS:Novel ways of accessing and engaging smokers who are socially and economically disadvantaged may help reduce socioeconomic disparities in smoking rates. This study assessed the feasibility and acceptability of integrating smoking cessation support into usual care at a social and community service ...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2011.00391.x
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION AND AIMS:The high prevalence of trauma exposure and post-traumatic stress disorder (PTSD) among clients of alcohol and other drug (AOD) services is well documented. Less is known, however, about the impact this has on workers who assess and treat such clients. The aim of this study was to examine the preva...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12204
更新日期:2015-05-01 00:00:00
abstract::Recently, there has been increased recognition of the importance of drug information systems (DIS), highlighting the need for an internationally coordinated approach to data collection and advocating the regular assessment of a range of areas. Accurate information provides policy makers with the evidence to evaluate c...
journal_title:Drug and alcohol review
pub_type: 杂志文章,评审
doi:10.1080/0959523021000059848
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION AND AIMS:Cigarette smoking occurs frequently among individuals with methamphetamine (MA) dependence. Preclinical and clinical evidence has suggested that the common co-abuse of MA and cigarettes represents a pharmacologically meaningful pattern. METHODS:The present study is a secondary analysis of a rando...
journal_title:Drug and alcohol review
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1465-3362.2012.00423.x
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:Unhealthy lifestyle behaviours can cluster to produce more detrimental overall health consequences than expected with a simple additive effect. This study aims to expand current knowledge of the nature and strength of the relationship between two such health behaviours, alcohol and diet, through a...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2011.00330.x
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION AND AIMS:The aims of this study were to examine the roles of parental permissiveness toward alcohol use and affiliation with alcohol-using peers in alcohol use in youths from various ethnic backgrounds, and whether the role of peers was moderated by parental permissiveness. In addition, differences in thes...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12555
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION AND AIMS:New strategies are required to reach subpopulations with high smoking rates. This study reports on an evaluation of the Smoking Care intervention-a 2-year organisational capacity building strategy--for social and community service organisations (SCSOs) to provide smoking care to clients. DESIGN A...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2012.00464.x
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION AND AIMS:Online gambling advertising and user-generated gambling content have increased. This study used a social psychological online experiment to analyse young people's reactions towards and self-reported interests in social media gambling messages. DESIGN AND METHODS:A vignette experiment with a two-l...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.13010
更新日期:2020-02-01 00:00:00
abstract::In response to the rising concerns about the rate of heroin-related fatalities, overdose prevention campaigns, run by both users' organizations and government agencies, have been implemented in a number of states across Australia. In Western Australia (WA) in mid-1997, various overdose prevention initiatives were impl...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/0959523021000023162
更新日期:2002-12-01 00:00:00
abstract::The objective of the study was to examine the relationship between alcohol consumption per adult (>/=15 years old) and expenditure on alcohol advertising per adult in Australia for the 18 years from 1969 to 1986. In addition, analyses were made of the extent to which annual changes in consumption were related to annua...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595239000185051
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:Gender differences have been reported in adult substance users, but little research has examined gender differences in adolescents presenting to treatment services. This study aimed to explore gender differences in adolescents presenting to a withdrawal service. DESIGN AND METHODS:All presentatio...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2009.00152.x
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION AND AIMS:Despite increasing HIV prevalence in cities along the Mexico--US border, HIV testing among high-risk populations remains low. We sought to identify barriers associated with HIV testing among injection drug users (IDUs) in Tijuana and Ciudad Juarez, the two largest Mexican border cities located acr...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595230701710845
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:A significant level of misreport or error occurs during questionnaire-based assessment of smoking behaviour. Failure to measure environmental tobacco smoke, and participant's inclination to under-report their smoking raise questions as to the accuracy of assessment. In order to establish an estima...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2009.00078.x
更新日期:2010-01-01 00:00:00
abstract::Studies of the processes by which people give up dependent heroin use are useful in helping services evaluate their treatment practices and in informing drug policy debates. In this exploratory investigation, a diverse group of 18 Canberra-based ex-users was interviewed about stopping, the role of treatment and their ...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595239400185381
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:Increased access for smokers to pharmacotherapies for smoking cessation suggests that pharmacists have a potential role in influencing how these pharmacotherapies are used in the community. This study aimed to identify the extent and type of advice provided by pharmacists to customers purchasing n...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595230701373966
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION AND AIMS:Few epidemiological studies have examined the behaviours and experiences of young adults during discrete drug-use events. This study was designed to capture a rich, detailed description of discrete occasions or 'sessions' of psychostimulant use. DESIGN AND METHODS:Participants were 220 young psyc...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12168
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION AND AIMS:Young adults have the highest rates of drug use and contribute significantly to the growing population of medical cannabis patients (MCP). This study examined relationships between longitudinal patterns of illicit/prescription drug use/misuse and cannabis practices among young adult cannabis users...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.13078
更新日期:2020-09-01 00:00:00
abstract::Approaches to the prevention of alcohol problems among Aboriginal people in Australia have tended to emphasize primary and tertiary prevention, while neglecting secondary prevention or early intervention. In contrast, members of the wider Australian community can now access a variety of early interventions through gen...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595239800187611
更新日期:1998-03-01 00:00:00
abstract:INTRODUCTION AND AIMS:The harm from alcohol and tobacco use in low- and middle-income countries includes substantial economic cost to the individual. Our aim was to describe the expenditure on concurrent alcohol and tobacco use in relation to family income in two districts in Sri Lanka. DESIGN AND METHODS:A community-...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2010.00202.x
更新日期:2011-01-01 00:00:00
abstract::Given the centrality of drug treatment to the drug court framework, the proliferation of drug courts in the United States, and their emergence more recently in Australia, it is surprising that such little attention has been given to assessing their therapeutic effect. This evaluation aimed to assess the health and wel...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595230310001613921
更新日期:2003-12-01 00:00:00
abstract:INTRODUCTION AND AIMS:At present there is little research into the use of drug detection dogs. The present study sought to explore the use of detection dogs in Sydney, Australia, utilising multiple data sources. DESIGN AND METHODS; Data were taken from interviews with 100 regular ecstasy users and 20 key experts as par...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2009.00065.x
更新日期:2009-11-01 00:00:00
abstract:INTRODUCTION AND AIMS:Researchers in a number of countries have recently identified major changes in adolescent alcohol consumption since the early 2000s, with the prevalence of teenage drinking more than halving in some countries. The major aims of the current study are to examine if there are sub-groups among non-dri...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12663
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION AND AIMS:This study aimed to compare current and ex-smokers' sociodemographic and psychosocial characteristics, use of cessation aids and abrupt versus gradual quitting approaches. DESIGN AND METHODS:A cross-sectional survey of financially disadvantaged adults attending a community service organisation wa...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12561
更新日期:2018-02-01 00:00:00