A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain.


:Safety and efficacy data from a study of slow intrathecal (IT) ziconotide titration for the management of severe chronic pain are presented. Patients randomized to ziconotide (n = 112) or placebo (n = 108) started IT infusion at 0.1 microg/hour (2.4 microg/day), increasing gradually (0.05-0.1 microg/hour increments) over 3 weeks. The ziconotide mean dose at termination was 0.29 microg/hour (6.96 microg/day). Patients' baseline Visual Analogue Scale of Pain Intensity (VASPI) score was 80.7 (SD 15). Statistical significance was noted for VASPI mean percentage improvement, baseline to Week 3 (ziconotide [14.7%] vs. placebo [7.2%; P = 0.036]) and many of the secondary efficacy outcomes measures. Significant adverse events (AEs) reported in the ziconotide group were dizziness, confusion, ataxia, abnormal gait, and memory impairment. Discontinuation rates for AEs and serious AEs were comparable for both groups. Slow titration of ziconotide, a nonopioid analgesic, to a low maximum dose resulted in significant improvement in pain and was better tolerated than in two previous controlled trials that used a faster titration to a higher mean dose.


J Pain Symptom Manage


Rauck RL,Wallace MS,Leong MS,Minehart M,Webster LR,Charapata SG,Abraham JE,Buffington DE,Ellis D,Kartzinel R,Ziconotide 301 Study Group.




Has Abstract


2006-05-01 00:00:00














  • Assessing fatigue in persons with cancer: further validation of the Wu Cancer Fatigue Scale.

    abstract::Cancer-related fatigue (CRF) is a significant clinical symptom. Effective assessment of CRF attributes from the patients' perspective is essential. This study tested the psychometric properties of the Wu Cancer Fatigue Scale (WCFS). A total of 172 outpatients with breast cancer, who were at various stages and on vario...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Wu HS,Wyrwich KW,McSweeney M

    更新日期:2006-09-01 00:00:00

  • For every numerator, you need a denominator: a simple statement but key to measuring the quality of care of the "dying".

    abstract::A mathematical rate is composed of a numerator, denominator, and time period of observation. Deciding who is in the denominator is a key, yet difficult task given the blurred boundaries of chronic illness, in examining the quality of care for dying patients. We propose two potential solutions. First, one could prospec...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: Teno JM,Coppola KM

    更新日期:1999-02-01 00:00:00

  • Palliative Care for Idiopathic Pulmonary Fibrosis Patients: Pulmonary Physicians' View.

    abstract:CONTEXT:Although idiopathic pulmonary fibrosis (IPF) has worse outcomes compared with most malignancies, patients with IPF receive poor access to optimal palliative care. OBJECTIVES:This study aimed to characterize the practice of pulmonologists regarding palliative care and end-of-life communication for patients with...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Akiyama N,Fujisawa T,Morita T,Mori K,Yasui H,Hozumi H,Suzuki Y,Karayama M,Furuhashi K,Enomoto N,Nakamura Y,Inui N,Suda T

    更新日期:2020-11-01 00:00:00

  • The complexity of nurses' attitudes and practice of sedation at the end of life: a systematic literature review.

    abstract:CONTEXT:Sedation is administered to some palliative care patients at the end of their life. Nurses play an important role in this practice. OBJECTIVES:To systematically review the evidence on nurses' attitudes and practice of end-of-life sedation. METHODS:We searched eight electronic databases, four key palliative ca...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: Abarshi EA,Papavasiliou ES,Preston N,Brown J,Payne S,EURO IMPACT.

    更新日期:2014-05-01 00:00:00

  • A comparison of the pharmacokinetics, clinical efficacy, and tolerability of once-daily tramadol tablets with normal release tramadol capsules.

    abstract::This report describes a pharmacokinetic study and a clinical study of three different formulations of oral tramadol: once-daily tramadol tablets 150 and 200 mg, and normal release tramadol capsules 50 mg 8-hourly. The randomized, open-label, crossover pharmacokinetic study included 22 subjects. The three treatments sh...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bodalia B,McDonald CJ,Smith KJ,O'Brien C,Cousens L

    更新日期:2003-02-01 00:00:00

  • Skin problems in advanced and terminal cancer patients.

    abstract::Disturbances caused by skin problems may compromise the quality of life of cancer patients. The main complications affecting the skin comprise the dermatologic toxicity of anticancer therapy, bedsores, malignant ulcers, sores due to nonmetastatic cancer, pruritus, and infections. Most of the information available abou...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: De Conno F,Ventafridda V,Saita L

    更新日期:1991-05-01 00:00:00

  • Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial.

    abstract:CONTEXT:Dyspnea is one of the most distressing symptoms in patients with cancer, and often worsens with breakthrough episodes on exertion. We hypothesized that fentanyl given prophylactically may alleviate breakthrough dyspnea. OBJECTIVES:To determine the feasibility of conducting a randomized trial of subcutaneous fe...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,随机对照试验


    authors: Hui D,Xu A,Frisbee-Hume S,Chisholm G,Morgado M,Reddy S,Bruera E

    更新日期:2014-02-01 00:00:00

  • Web-Based Tailored Psychoeducation for Breast Cancer Patients at the Onset of the Survivorship Phase: A Multicenter Randomized Controlled Trial.

    abstract:CONTEXT:Many breast cancer patients have unmet informational and psychosocial needs after treatment completion. A psychoeducational intervention may be well suited to support these patients. OBJECTIVES:The purpose of this multicenter randomized controlled trial was to examine the effectiveness of a web-based tailored ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Admiraal JM,van der Velden AWG,Geerling JI,Burgerhof JGM,Bouma G,Walenkamp AME,de Vries EGE,Schröder CP,Reyners AKL

    更新日期:2017-10-01 00:00:00

  • Hospice partnerships with academic entities: philosophical and historical background and assessment of future needs.

    abstract::There is consensus that more research is needed to help improve care at the end of life. Despite the fact that hospices take care of more and more dying persons every year, hospice organizations have not been highly involved in research. The National Hospice Work Group is comprised of hospice organizations that have m...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Tolley DC,Payne R

    更新日期:2007-01-01 00:00:00

  • The need for palliative care in Ireland: a population-based estimate of palliative care using routine mortality data, inclusive of nonmalignant conditions.

    abstract:CONTEXT:Over the history of palliative care provision in Ireland, services have predominantly provided care to those with cancer. Previous estimates of palliative care need focused primarily on specialist palliative care and included only a limited number of nonmalignant diseases. OBJECTIVES:The primary aim of this st...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Kane PM,Daveson BA,Ryan K,McQuillan R,Higginson IJ,Murtagh FE,BuildCARE.

    更新日期:2015-04-01 00:00:00

  • Hearing Loss in Hospice and Palliative Care: A National Survey of Providers.

    abstract:CONTEXT:Age-related hearing loss can impair patient-provider communication about symptom management, goals of care, and end-of-life decision-making. OBJECTIVES:To determine whether hospice and palliative care providers screen for or received training about hearing loss, believe it impacts patient care, and use strateg...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Smith AK,Ritchie CS,Wallhagen ML

    更新日期:2016-08-01 00:00:00

  • Meaninglessness in terminally ill cancer patients: a randomized controlled study.

    abstract::Although recent empirical studies reveal that fostering patients' perception of meaning in their lives is an essential task for palliative care clinicians, few studies have reported the effects of training programs for nurses specifically aimed at improving these skills. The primary aim of this randomized controlled t...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,随机对照试验


    authors: Morita T,Murata H,Kishi E,Miyashita M,Yamaguchi T,Uchitomi Y,Japanese Spiritual Care Task Force.

    更新日期:2009-04-01 00:00:00

  • Multidisciplinary management of cancer pain: a longitudinal retrospective study on a cohort of end-stage cancer patients.

    abstract::The epidemiology of cancer pain and the outcomes associated with pain treatments were investigated through a retrospective survey of 772 patients with advanced cancer. The cumulative prevalence of pain was 87%, including all types of cancer. Mean duration of pain was 6.9+/-8.1 months. The prevalence of pain was 28%, 4...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Peng WL,Wu GJ,Sun WZ,Chen JC,Huang AT

    更新日期:2006-11-01 00:00:00

  • Effects of a brief coping skills training intervention on nociceptive flexion reflex threshold in patients having osteoarthritic knee pain: a preliminary laboratory study of sex differences.

    abstract::Studies have documented the efficacy of coping skills training (CST) for managing pain, distress, and disability in persons with arthritis. However, no laboratory studies have examined the effects of CST on descending modulation of nociception. This study used the nociceptive flexion reflex (NFR) to document pain and ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Emery CF,Keefe FJ,France CR,Affleck G,Waters S,Fondow MD,McKee DC,France JL,Hackshaw KV,Caldwell DS,Stainbrook D

    更新日期:2006-03-01 00:00:00

  • Can just-in-time, evidence-based "reminders" improve pain management among home health care nurses and their patients?

    abstract::The purpose of this randomized, controlled, home care intervention was to test the effectiveness of two nurse-targeted, e-mail-based interventions to increase home care nurses' adherence to pain assessment and management guidelines, and to improve patient outcomes. Nurses from a large urban non-profit home care organi...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McDonald MV,Pezzin LE,Feldman PH,Murtaugh CM,Peng TR

    更新日期:2005-05-01 00:00:00

  • Artificial hydration therapy for terminally ill cancer patients: a nurse-education intervention.

    abstract::The Japanese Society of Palliative Medicine has developed a clinical guideline to minimize the large variation in clinical practice of artificial hydration therapy for terminally ill cancer patients. The primary aim of this preliminary study was to explore the effects of a five-hour interactive workshop based on the g...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Yamagishi A,Tanaka F,Morita T

    更新日期:2009-09-01 00:00:00

  • Preferences for End-of-Life Care and Decision Making Among Older and Seriously Ill Inpatients: A Cross-Sectional Study.

    abstract:CONTEXT:Older and seriously ill Australians are often admitted to hospital in the last year of their life. The extent to which these individuals have considered important aspects of end-of-life (EOL) care, including location in which care is provided, goals of care, and involvement of others in decision making, is uncl...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Waller A,Sanson-Fisher R,Nair BR,Evans T

    更新日期:2020-02-01 00:00:00

  • Efficacy and safety of the seven-day buprenorphine transdermal system in opioid-naïve patients with moderate to severe chronic low back pain: an enriched, randomized, double-blind, placebo-controlled study.

    abstract:CONTEXT:This article presents the results of a pivotal Phase 3 study that assesses a new treatment for the management of chronic low back pain: a transdermal patch containing the opioid buprenorphine. In this randomized, placebo-controlled study with an enriched enrollment design, the buprenorphine transdermal system (...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,随机对照试验


    authors: Steiner DJ,Sitar S,Wen W,Sawyerr G,Munera C,Ripa SR,Landau C

    更新日期:2011-12-01 00:00:00

  • The frequency of alcoholism among patients with pain due to terminal cancer.

    abstract::The purpose of this retrospective study was to determine the prevalence of alcoholism among terminally ill cancer patients when assessed by multidisciplinary interviews and by the CAGE Questionnaire. We reviewed the charts of 100 consecutive patients assessed by a multidisciplinary team for the presence of alcoholism ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Bruera E,Moyano J,Seifert L,Fainsinger RL,Hanson J,Suarez-Almazor M

    更新日期:1995-11-01 00:00:00

  • Fatigue, dyspnea, and cough comprise a persistent symptom cluster up to five years after diagnosis with lung cancer.

    abstract:CONTEXT:Aggregates of concurrent symptoms, known as symptom clusters (SxCls), have been described in predominantly cross-sectional samples of lung cancer (LC) patients undergoing treatment. OBJECTIVES:The objective of this study was to delineate SxCls in LC survivors up to five years after diagnosis, investigate their...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Cheville AL,Novotny PJ,Sloan JA,Basford JR,Wampfler JA,Garces YI,Jatoi A,Yang P

    更新日期:2011-08-01 00:00:00

  • Can senior volunteers deliver reminiscence and creative activity interventions? Results of the legacy intervention family enactment randomized controlled trial.

    abstract:CONTEXT:Palliative care patients and their family caregivers may have a foreshortened perspective of the time left to live, or the expectation of the patient's death in the near future. Patients and caregivers may report distress in physical, psychological, or existential/spiritual realms. OBJECTIVES:To conduct a rand...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,随机对照试验


    authors: Allen RS,Harris GM,Burgio LD,Azuero CB,Miller LA,Shin HJ,Eichorst MK,Csikai EL,DeCoster J,Dunn LL,Kvale E,Parmelee P

    更新日期:2014-10-01 00:00:00

  • Chronic pain in breast cancer survivors: comparison of psychosocial, surgical, and medical characteristics between survivors with and without pain.

    abstract:CONTEXT:According to the literature, 25%-60% of women treated for breast cancer, regardless of the stage, experience pain. Many risk factors have been suggested, with many possible confounding factors. OBJECTIVES:The aim was to investigate psychosocial, surgical, and medical factors associated with chronic pain by com...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Schou Bredal I,Smeby NA,Ottesen S,Warncke T,Schlichting E

    更新日期:2014-11-01 00:00:00

  • Prescription and Deprescription of Medication During the Last 48 Hours of Life: Multicenter Study in 23 Acute Geriatric Wards in Flanders, Belgium.

    abstract:CONTEXT:Palliative care for the older person is often limited, resulting in poor quality of dying. Pharmacological management can be one of the components to achieve better symptom control. OBJECTIVES:To describe the anticipatory prescription of medication for symptomatic treatment and the deprescription of potentiall...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究


    authors: Van Den Noortgate NJ,Verhofstede R,Cohen J,Piers RD,Deliens L,Smets T

    更新日期:2016-06-01 00:00:00

  • Disparities in the contribution of low- and middle-income countries to palliative care research.

    abstract:CONTEXT:Important aspects of the palliative care needs of patients from low- and middle-income countries (LMIC) are largely unexplored. About 44 million of the 56 million annual deaths worldwide occur in developing countries, and it is estimated that more than 33 million of those concerned would benefit from palliative...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Pastrana T,Vallath N,Mastrojohn J,Namukwaya E,Kumar S,Radbruch L,Clark D

    更新日期:2010-01-01 00:00:00

  • A randomized double-blind crossover trial of intravenous lidocaine in the treatment of neuropathic cancer pain.

    abstract::In a randomized, double-blind, crossover study, we evaluated the effect of intravenous lidocaine (5 mg/kg body weight over 30 min) on the neuropathic pain of advanced cancer patients. Pain intensity, assessed by a visual analogue scale, did not show any significant difference between lidocaine and placebo infusion. Th...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,随机对照试验


    authors: Bruera E,Ripamonti C,Brenneis C,Macmillan K,Hanson J

    更新日期:1992-04-01 00:00:00

  • Understanding the causes of problematic pain management in sickle cell disease: evidence that pseudoaddiction plays a more important role than genuine analgesic dependence.

    abstract::Treatment of painful episodes in sickle cell disease (SCD) is sometimes complicated by disputes between patients and staff and patient behaviors that raise concerns about analgesic misuse. Those concern-raising behaviors could indicate either drug seeking caused by analgesic dependence or pseudoaddiction caused by und...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Elander J,Lusher J,Bevan D,Telfer P,Burton B

    更新日期:2004-02-01 00:00:00

  • Breakthrough pain in advanced cancer patients followed at home: a longitudinal study.

    abstract::The aim of this study was to longitudinally assess breakthrough pain (BP) in advanced cancer patients who were admitted to home palliative care. One hundred and one consecutive patients who were admitted to one of the two home care programs and were representative of the cancer population followed at home in Italy wer...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Mercadante S,Costanzo BV,Fusco F,Buttà V,Vitrano V,Casuccio A

    更新日期:2009-10-01 00:00:00

  • Development and validation of the breakthrough pain assessment tool (BAT) in cancer patients.

    abstract:CONTEXT:The successful management of breakthrough pain depends on a combination of adequate assessment, appropriate (individualized) treatment, and adequate re-assessment. Currently, there is no fully validated clinical assessment tool for breakthrough pain in cancer patients. OBJECTIVES:The aim of this project was to...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Webber K,Davies AN,Zeppetella G,Cowie MR

    更新日期:2014-10-01 00:00:00

  • An assessment of methods used to evaluate the adequacy of cancer pain management.

    abstract::This paper assesses different methods of evaluating pain management. We used the established methods of pain prevalence measurement and the Pain Management Index (PMI) to compare pain management between two groups who might be expected to have different outcomes. We also developed and used a method to assess how quick...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Russell PB,Aveyard SC,Oxenham DR

    更新日期:2006-12-01 00:00:00

  • Preferences and Experiences of Muslim Patients and Their Families in Muslim-Majority Countries for End-of-Life Care: A Systematic Review and Thematic Analysis.

    abstract:BACKGROUND:Care for people with progressive illness should be person centered and account for their cultural values and spiritual beliefs. There are an estimated 1.7 billion Muslims worldwide, largely living in low-income and middle-income countries. AIMS:This study aimed to identify, appraise, and integrate the evide...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: Abdullah R,Guo P,Harding R

    更新日期:2020-12-01 00:00:00