Abstract:
:Mitochondrial DNA variability in the Polish Roma population has been studied by means of hypervariable segment I and II (HVS I and II) sequencing and restriction fragment-length polymorphism analysis of the mtDNA coding region. The mtDNA haplotypes detected in the Polish Roma fall into the common Eurasian mitochondrial haplogroups (H, U3, K, J1, X, I, W, and M*). The results of complete mtDNA sequencing clearly indicate that the Romani M*-lineage belongs to the Indian-specific haplogroup M5, which is characterized by three transitions in the coding region, at sites 12477, 3921 and 709. Molecular variance analysis inferred from mtDNA data reveals that genetic distances between the Roma groups are considerably larger than those between the surrounding European populations. Also, there are significant differences between the Bulgarian Roma (Balkan and Vlax groups) and West European Roma (Polish, Lithuanian and Spanish groups). Comparative analysis of mtDNA haplotypes in the Roma populations shows that different haplotypes appear to demonstrate impressive founder effects: M5 and H (16261-16304) in all Romani groups; U3, I and J1 in some Romani groups. Interestingly, haplogroup K (with HVS I motif 16224-16234-16311) found in the Polish Roma sample seems to be specific for Ashkenazi Jewish populations.
journal_name
Ann Hum Genetjournal_title
Annals of human geneticsauthors
Malyarchuk BA,Grzybowski T,Derenko MV,Czarny J,Miścicka-Sliwka Ddoi
10.1111/j.1529-8817.2005.00222.xsubject
Has Abstractpub_date
2006-03-01 00:00:00pages
195-206issue
Pt 2eissn
0003-4800issn
1469-1809pii
AHG222journal_volume
70pub_type
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journal_title:Annals of human genetics
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journal_title:Annals of human genetics
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pub_type: 杂志文章
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journal_title:Annals of human genetics
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journal_title:Annals of human genetics
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journal_title:Annals of human genetics
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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journal_title:Annals of human genetics
pub_type: 杂志文章
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journal_title:Annals of human genetics
pub_type: 杂志文章,meta分析
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journal_title:Annals of human genetics
pub_type: 杂志文章
doi:10.1111/j.1469-1809.1984.tb00846.x
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journal_title:Annals of human genetics
pub_type: 杂志文章
doi:10.1111/j.1469-1809.1981.tb00334.x
更新日期:1981-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Annals of human genetics
pub_type: 杂志文章
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journal_title:Annals of human genetics
pub_type: 杂志文章
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journal_title:Annals of human genetics
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Annals of human genetics
pub_type: 杂志文章,评审
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journal_title:Annals of human genetics
pub_type: 杂志文章
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