Biochemical characterization of the genetic variants of human phosphoglycolate phosphatase (PGP).

Abstract:

:Phosphoglycolate phosphatase (PGP) exhibits a wide range of activities in normal human red cells. Analysis of blood from 57 individuals of known PGP phenotype revealed no correlation between enzyme activity, electrophoretic phenotype or 2,3-DPG concentration. Neither was there evidence of variation in Km, heat stability, pH optimum or molecular size among the various electrophoretic phenotypes. However, human red cell PGP exhibits high (0.24 mM) and low (0.05 mM) Km values for phosphoglycolate irrespective of phenotype and this requires further analysis.

journal_name

Ann Hum Genet

journal_title

Annals of human genetics

authors

Turner VS,Hopkinson DA

doi

10.1111/j.1469-1809.1981.tb00313.x

subject

Has Abstract

pub_date

1981-05-01 00:00:00

pages

121-7

issue

2

eissn

0003-4800

issn

1469-1809

journal_volume

45

pub_type

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