Abstract:
:In the last decade much attention has been paid to the development of metabolically non-reversible dimeric or hybrid compounds, which combine two structural units of one or two lead compounds of interest for the treatment of Alzheimer's disease. As a consequence of their capability to simultaneously interact with two binding sites of the same biological target (the enzyme acetylcholinesterase in most cases), to expand their interaction in the main binding site of the target molecule, or to interact with two different biological targets of interest in the pathogenesis of the disease, these dimeric or hybrid compounds exhibit an improved pharmacological profile including high affinity interactions, additional non conventional actions or complementary actions, what makes them potential drug candidates for the treatment of Alzheimer's disease. Herein, we review from a structural point of view the main classes of dimeric or hybrid compounds developed for the treatment of Alzheimer's disease, along with the pharmacological profile of the most active compounds.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Muñoz-Torrero D,Camps Pdoi
10.2174/092986706775527974subject
Has Abstractpub_date
2006-01-01 00:00:00pages
399-422issue
4eissn
0929-8673issn
1875-533Xjournal_volume
13pub_type
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