[Prostate cancer diagnosis using 24 cores extended biopsy].

Abstract:

OBJECTIVE:To determine the diagnostic performance of extended prostatic biopsy (PB) in prostate cancer (PC) and variables affecting positivity. MATERIALS AND METHODS:Patients (n = 147) underwent 24 cylinder PB at the Arquitecto Marcide Hospital, Ferrol, La Coruña, between December 2002-September 2004. Inclusion criteria were the following: patients aged < or = 70 with one or more negative PB or aged < or = 75 with two or more negative PB. An univariate analysis was carried out using the chi-squared test for the qualitative variables and the t-Student and U Mann-Whitney tests in the case of the quantitative variables, plus a logistical regression analysis in order to identify those variables related to the extended PB positivity. RESULTS:60 patients (40.82%) were identified as having PC. Significant differences were observed in prostatic volume, free/total PSA ratio in the initial PB, free/total PSA ratio in the extended PB, PSA-density in the extended PB as well as the existence of chronic prostatitis in previous PB. During the multivariate analysis it was found that the PSA-density and the presence of chronic prostatitis in previous PB independently predicted the positivity of the extended PB. CONCLUSIONS:Extended PB allows for the detection of PC in 40.82% of patients with previous negative PB. The increase in PSA density is associated with a greater probability of PC, whilst the existence of chronic prostatitis in prior PB significantly reduces the probability of PC in the extended PB.

journal_name

Actas Urol Esp

authors

Rodríguez Alonso A,González Blanco A,Pita Fernandez S,Suárez Pascual G,Bonelli Martín C,Lorenzo Franco J,Alvarez Fernández JC,Cuerpo Pérez MA

doi

10.1016/s0210-4806(05)73373-8

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

934-42

issue

10

eissn

0210-4806

issn

1699-7980

pii

S0210-4806(05)73373-8

journal_volume

29

pub_type

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