Cisplatin-related hiccups: male predominance, induction by dexamethasone, and protection against nausea and vomiting.

Abstract:

:Dexamethasone is likely to play a role in the etiology of hiccups in patients receiving cisplatin-based regimens. Two hundred seventy-seven patients received three doses of ondansetron 8mg intravenously (IV) at 4hour intervals plus dexamethasone 20mg IV from the start of chemotherapy, followed by dexamethasone 5mg IV every 12hours, until chemotherapy was complete. Hiccups were observed in 114 (41.2%) patients, of whom 97.4% were men. Nausea and vomiting showed inverse correlations with hiccups (P < 0.0001 and P = 0.001, respectively). In 73 patients who experienced hiccups but lacked nausea/vomiting (H+N/V-), we discontinued dexamethasone in subsequent cycles. Sixty-six patients (90.4%) ceased hiccuping, but complete protection rates of nausea and vomiting decreased to 63% and 74%, respectively. For patients who experienced both hiccups and nausea/vomiting, the onset of nausea/vomiting usually was delayed to Day 3 or 4 and began after the cessation of hiccups. We conclude that cisplatin-related hiccups are predominant in males, dexamethasone-induced, and associated with protection against nausea/vomiting.

journal_name

J Pain Symptom Manage

authors

Liaw CC,Wang CH,Chang HK,Wang HM,Huang JS,Lin YC,Chen JS

doi

10.1016/j.jpainsymman.2005.08.008

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

359-66

issue

4

eissn

0885-3924

issn

1873-6513

pii

S0885-3924(05)00432-X

journal_volume

30

pub_type

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