Methemoglobinemia: nitrate toxicity in rural America.

Abstract:

:Nitrates are frequently found in vegetables and ground water. Nitrate levels in ground water have increased over the past two decades because of the heightened use of nitrogenous fertilizers. Following ingestion, nitrates are converted to nitrites by fecal organisms. Nitrites are absorbed and form methemoglobin, which interferes with the oxygen-carrying capacity of hemoglobin. Infants are particularly susceptible to nitrate poisoning because fetal hemoglobin is more readily oxidized to methemoglobin. In infants, the most common source of nitrate exposure is well water, which is mixed with infant formula. Affected infants may present with asymptomatic cyanosis, which can progress to dyspnea and lethargy or coma. Blood methemoglobin concentrations are elevated. Treatment consists of the administration of oxygen and intravenous and oral methylene blue.

journal_name

Am Fam Physician

authors

Kross BC,Ayebo AD,Fuortes LJ

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

183-8

issue

1

eissn

0002-838X

issn

1532-0650

journal_volume

46

pub_type

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