Abstract:
:Sildenafil is a cyclic guanosine-specific phosphodiesterase type 5 (PD-5) inhibitor that is widely used for erectile dysfunction. Potent and competitive inhibition of PD-5 enhances levels of cyclic guanosine monophosphate (cGMP). Fibrin glue-apart from tissue fixation-has been used for slow release of drugs. In this study, local delivery of Sildenafil citrate with fibrin glue was accomplished to improve random flap survival. Fifty Wistar rats were randomized into 5 groups, and a standardized dorsal random-pattern skin flap was elevated in each rat. In Group I (n = 10), the base of the flap was divided, making it a "graft" control to study the graft effect. In Group II (n = 10), a thin Silastic sheet was used to separate the flap from the underlying vascular bed, and no pharmacologic treatment was given. In Group III (n = 10), only 0.5 mL of fibrin glue was applied to the flap donor site. In Group IV (n = 10), 2.5 mg of sildenafil citrate mixed in 0.5 mL of fibrin glue was applied to donor site of the flap, whereas 10 mg of sildenafil citrate mixed in 0.5 mL of fibrin glue was applied in Group V (n = 10). Area of flap survival was evaluated on postoperative seventh day. Total necrosis of all of the flaps was observed in "graft" control group (Group I). Sildenafil and fibrin glue groups (Group IV and V) resulted in a statistically significant decrease in flap necrosis compared with Groups II and III (P < 0.0001). A statistically significant difference could not be documented between Group II and Group III (P > 0.0001). The decrease in skin necrosis was statistically significant in Group V compared with Group IV (P < 0.0001). Histologic examination revealed significantly increased vascular density in Groups IV and V compared with Groups II and III (P < 0.0001), whereas a significant difference could not be documented between Groups IV and V (P > 0.0001) and between Groups II and III (P > 0.0001). In view of these results, topical sildenafil application seems to improve flap survival in random-pattern skin flaps in dose-dependent manner.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Ulusoy MG,Uysal A,Koçer U,Karaaslan O,Cuzdan SS,Ayyildiz A,Ustün Hdoi
10.1097/01.sap.0000175483.35073.easubject
Has Abstractpub_date
2005-09-01 00:00:00pages
292-6issue
3eissn
0148-7043issn
1536-3708pii
00000637-200509000-00015journal_volume
55pub_type
杂志文章abstract:ABSTRACT:The era of genetics and precision medicine has been reforming this world. How will plastic surgeons in the field of vascular anomalies conform to the trend? This article systematically reviews the identification of serum biomarkers, risk factors, specific mutations in the angiogenesis-related genes such as GNA...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002723
更新日期:2021-01-19 00:00:00
abstract::The most common cause of nasal obstruction is chronic enlargement of the inferior turbinate bones. The variety of medical and surgical treatments available for this condition bears testimony to their frequent ineffectiveness and the frustration of the physician or surgeon caring for these patients. Removal or destruct...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197909000-00009
更新日期:1979-09-01 00:00:00
abstract::Hemangioma of the zygomatic bone is an extreme rarity. Six cases have been reported in the English literature. These reports and the 2 new patients presented here constitute the basis for our data. Clinical, histopathological, therapeutic, and reconstructive considerations are discussed. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198706000-00013
更新日期:1987-06-01 00:00:00
abstract::The treatment of diabetic wounds is a considerable clinical challenge. In this study, mouse dermal fibroblasts retrovirally transduced with the human platelet-derived growth factor B (PDGF-B) gene were used to treat diabetic mouse wounds. The PDGF-B gene was obtained from human umbilical vein endothelial cells, cloned...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000084461.83554.71
更新日期:2003-10-01 00:00:00
abstract::From an anatomical standpoint, the support of the inferior two thirds of the nose is ensured by the cartilaginous septum. Usually, the reconstruction of total loss of the quadrangular cartilage is performed with some success by means of camouflage procedures such as L-shaped struts or cantilever grafts. In this articl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199506000-00010
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Attempts to salvage upper and lower extremities have performed more frequently in recent decades, although there are clear cases that cannot be salvaged. The purpose of this retrospective study was to present our experience in using free calcaneus osteocutaneous fillet flap for preserving below-knee amputati...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001775
更新日期:2019-08-01 00:00:00
abstract::Breast augmentation is one of the leading esthetic surgeries, enjoying high satisfaction rates. Pain, nausea, and vomiting are frequent shortcomings of the immediate postoperative period. The aim of this study was to compare breast augmentation from the anesthetic point of view: general anesthesia (GA) versus monitore...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31815bfe98
更新日期:2008-09-01 00:00:00
abstract::We have developed a new in vivo model for the study of fetal wound healing. Fetal ICR mice (total gestation, 21 days) received a full-thickness incisional wound in the hind limb at gestational day 14 (N = 100). The wound was made with a 28.5-gauge needle that was passed transplacentally into the amniotic cavity. The w...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199710000-00008
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Chest wall reconstruction after radiation damage is a challenge in oncologic and plastic surgery. The defect can be reconstructed with laparoscopically harvested omental flap and meshed skin grafts. Our aim was to evaluate the use of vacuum-assisted closure (V.A.C.) in combination with laparoscopically harve...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000237644.29878.0f
更新日期:2007-02-01 00:00:00
abstract::The relative merit of cartilage scoring versus suturing in otoplasty remains a subject of debate among leading plastic surgeons. We compared a variety of otoplasty techniques in 42 rabbit ears using anterior or posterior scoring, horizontal or vertical mattress sutures, and combinations of scoring and suturing. The ea...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199501000-00009
更新日期:1995-01-01 00:00:00
abstract:ABSTRACT:The first dorsal metacarpal artery free flap is widely known for its use as a pedicled flap in thumb and hand reconstruction; however, its potential for use as a free flap is less well known. We previously described successful use of the first dorsal metacarpal artery free flap for salvage of a subtotal nasal ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002510
更新日期:2020-08-21 00:00:00
abstract::Prostaglandin E1 has been proven to be useful in the treatment of vascular diseases of the lower leg. Plastic surgeons have been aware of its usefulness in augmenting flap survival and have used it intraarterially or intravenously. We attempted to enhance the effect of prostaglandin E1 with heparin by local continuous...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199302000-00010
更新日期:1993-02-01 00:00:00
abstract::The management of keloids and hypertrophic scars continues to challenge health-care providers. Though both forms of pathologic scarring are distinct entities at the macro and microscopic level, their etiologies and treatment are often similar. Potential treatment approaches are progressing, and combinations of treatme...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e3181afaab0
更新日期:2010-03-01 00:00:00
abstract::Traumatic hemipelvectomy is an uncommon and devastating injury with few patients alive when they reach the hospital. There are only 19 reported survivors of this injury. This group includes 17 males and 2 females. All had severe, associated injuries. The mechanism of injury involved motorcycle, automobile, pedestrian/...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-199108000-00011
更新日期:1991-08-01 00:00:00
abstract:INTRODUCTION:Sacropelvic resection is the treatment of choice for pelvic bone tumors and can be associated with intraoperative electron radiotherapy (IOERT) to optimize local control of the disease. Reconstruction with flaps also is essential to avoid pelvic complications. There is scarcity of publications evaluating o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002571
更新日期:2020-12-15 00:00:00
abstract::Facial contours are thought to depend on the appropriate balance of hard and soft tissue. To obtain aesthetically good results in head and neck reconstruction, surgeons should know the exact three-dimensional shape and volume of both hard and soft tissue to be reconstructed. The authors used computer-assisted three-di...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200104000-00006
更新日期:2001-04-01 00:00:00
abstract::Axillary hyperhidrosis, although not life-threatening, is a troublesome condition which produces a personal and social handicap of great significance to patients for many years before they seek a cure. Treatment has consisted of application of topical antiperspirants, systemic anticholinergic medications, excision and...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198712000-00013
更新日期:1987-12-01 00:00:00
abstract::We report a 25-year-old woman who suffered traumatic damage to the medial malleolar area. Arteriography revealed a posterior tibial artery occlusion at the ankle. The predominant pattern of medial soleus vascularization was revealed during surgery. A reverse medial soleus flap including the posterior tibial pedicle wa...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199810000-00018
更新日期:1998-10-01 00:00:00
abstract::In this study, the feasibility of Integra acellular collagen used as a vascular carrier in skin flap prefabrication was examined. In all, 20 Sprague--Dawley rats were randomly divided into 3 groups. The saphenous vascular bundle was used as the vascular carrier. In group 1 (n = 8), an arteriovenous fistula was made by...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181fabc32
更新日期:2011-09-01 00:00:00
abstract::Management of soft-tissue defects over the Achilles tendon presents specific challenges to the plastic surgeon. Primary closure or local flaps are often not feasible repair options for such wounds, and many of these patients may be poor candidates for free-tissue transfer secondary to their comorbidity. In this case s...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000181342.25065.60
更新日期:2005-10-01 00:00:00
abstract::A histologically benign tumor of the temporal bone became a life-threatening neoplasm. Previous surgical procedures and a course of radiotherapy failed to arrest the growth of the neoplasm. Our therapeutic objectives were fourfold: (1) ventilation of tumor histology; (2) total tumor removal without an increase of the ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198302000-00010
更新日期:1983-02-01 00:00:00
abstract::There is a need in plastic and reconstructive surgery for a method of monitoring flaps and replants pre- and postoperatively. This study evaluates color flow Doppler done as a monitoring technique for microvascular vessels. The capability of color flow ultrasound to monitor venous and arterial insufficiency and occlus...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199303000-00001
更新日期:1993-03-01 00:00:00
abstract::A new genioplasty technique has been described and performed on 16 patients since 1995. The technique has been developed to avoid some undesired results of the current osseous genioplasty techniques and to achieve a more natural appearance in advancement genioplasty. According to the authors' technique, a rectangular ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to demonstrate the viability of the transverse circumflex scapular artery perforator flap (TCSAPF) in children with soft tissue defects of the lower limb. METHODS:In an anatomic study, 25 fresh cadavers were injected with lead oxide-gelatin for spiral computed tomography and 3-dimensi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002365
更新日期:2020-05-01 00:00:00
abstract::The quantitative and morphological characteristics of microbial adherence of four organisms--Staphylococcus epidermidis, S. aureus, Escherichia coli and Candida albicans--to the surfaces of different breast prostheses were observed. Semiquantitative adherence studies based on a modification of Maki's roll culture tech...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198904000-00009
更新日期:1989-04-01 00:00:00
abstract::Blepharoptosis surgery is one of the most common oculoplastic procedures, and the aim is to clear the visual axis. Many surgical techniques for the correction of ptosis have been described and performed, but the operative approach is based on the extent of eyelid excursion, the amount of levator function, and the degr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181de838a
更新日期:2011-03-01 00:00:00
abstract::Four cases of unilateral temporomandibular (TM) joint ankylosis were successfully treated by metatarsophalangeal to TM joint replacement by microvascular technique. Results 6 to 20 months postoperatively were encouraging. Further follow-up studies are necessary to evaluate the long-term results. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198512000-00008
更新日期:1985-12-01 00:00:00
abstract::Correction of major saddle nose deformities is one of the greatest challenges in nasal surgery. Here, a new approach for the correction of major saddle nose deformities in which the missing parts of the nasal skeleton are replaced with their anatomic replicas sculptured from an autogenous osteocartilagineous rib graft...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181586069
更新日期:2008-08-01 00:00:00
abstract::A 17-year-old patient whose left ear was reconstructed using a lateral arm fascia and skin graft had done well until one episode of cold exposure approximately two years after the reconstruction. This thermal injury resulted in a localized area of composite tissue loss demonstrating that the reconstructed ear had a hi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199402000-00004
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Early hepatic artery (HA) thrombosis and primary graft failure contribute greatly to the mortality of patients after liver transplantation. Herein, we present the treatment of intimal injury of HA by intraoperative fluorescence vascular stenting. METHODS:A sample of 471 patients receiving liver transplantat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001899
更新日期:2019-08-01 00:00:00