Abstract:
:The management of keloids and hypertrophic scars continues to challenge health-care providers. Though both forms of pathologic scarring are distinct entities at the macro and microscopic level, their etiologies and treatment are often similar. Potential treatment approaches are progressing, and combinations of treatment options have been proposed in the literature with promising outcomes. The treatment evolution has reached a level where molecular therapeutic modalities are being investigated. Currently, no gold standard treatment exists. Overall success rates and patient satisfaction seem to be slowly climbing, but additional investigational studies must continue to be performed. Several studies have investigated antineoplastic agents, and there seems to be a marked improvement in rates of recurrence, patient satisfaction, and overall quality of scar when these agents are used. Intralesional injection and/or wound irrigation with interferon-a2b, interferon-g, mitomycin-C, bleomycin, or 5-fluorouracil seems to have a positive effect on the reduction of pathologic scars. There is mounting evidence that these drugs used alone or in combination therapy, have the potential to be an integral part of the treatment paradigm for hypertrophic scars and keloids.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Shridharani SM,Magarakis M,Manson PN,Singh NK,Basdag B,Rosson GDdoi
10.1097/SAP.0b013e3181afaab0subject
Has Abstractpub_date
2010-03-01 00:00:00pages
355-61issue
3eissn
0148-7043issn
1536-3708pii
00000637-201003000-00024journal_volume
64pub_type
杂志文章,评审abstract::A case of a closed rupture of a single slip of flexor digitorum superficialis to the little finger is described. Closed rupture injuries of the flexor digitorum profundus tendon are quite common, but closed injuries to the superficialis tendon have been rarely reported. A single slip avulsion rupture of this tendon wo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200110000-00012
更新日期:2001-10-01 00:00:00
abstract::Historically, biologic materials found in nature have been used for a wide variety of medicinal purposes, although their widespread use may be limited due to challenges in obtaining and properly preparing the material for safe clinical use. Amniotic membrane has long been recognized to possess unique properties favora...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0000000000000983
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The challenging breast reshaping after massive weight loss (MWL) has been increasingly performed as the number of bariatric surgery procedures increase worldwide. The breasts often appear wide, lateralized, and deflated, with significant ptosis. OBJECTIVES:The aim of this article is to share our initial exp...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章
doi:10.1097/SAP.0000000000000816
更新日期:2017-02-01 00:00:00
abstract::Full-thickness excision wounds infected with Staphylococcus hyicus, a pig pathogen, or Staphylococcus aureus, a human pathogen, were produced in pigs. The inoculated wounds were kept occluded for 2 days and then exposed and biopsied at intervals for 9 to 12 days. The exposed lesions were edematous and exudative. The S...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198909000-00004
更新日期:1989-09-01 00:00:00
abstract::Disciplines using human body surface dimensions require accurate, repeatable measurements. This study presents a design for the analysis of repeatability, precision, and validation of a new anthropometric device. This model enables estimation of the proportion of the total variation attributable to each level of data ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199504000-00004
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the efficacy and safety of endovenous laser photocoagulation (EVLP) at a wavelength of 810 nm for treating complicated venous insufficiency associated with venous ulcers. MATERIALS AND METHODS:A retrospective review of 110 patients with 180 legs having chronic venou...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001726
更新日期:2019-01-01 00:00:00
abstract::Primary nerve grafting in traumatic injuries is rarely performed because of the uncertainty of the extent of injury, the limited availability of nerve grafts, and the damage to adjacent soft tissue. In this report the authors present two cases of acute nerve grafting after trauma-the first of the common peroneal nerve...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200111000-00015
更新日期:2001-11-01 00:00:00
abstract::The reconstruction of scalp defects presents a clinical challenge. Free tissue transfer has played an increasingly important role in the reconstruction of complex scalp defects. In many cases, patient medical comorbidities along with the length of the operative procedures incurs significant patient risk. Artificial de...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318180c913
更新日期:2009-06-01 00:00:00
abstract::A large craniofacial defect resulting from a close-range shotgun blast is described. It involves the left hemimandible, the left maxilla, the hard palate with nasal support, the roof of the left orbit, and the left side of the oral lining. The defect was reconstructed using autogenous ribs for the facial skeleton. The...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198101000-00007
更新日期:1981-01-01 00:00:00
abstract::Dermatofibrosarcoma protuberans is an unusual soft-tissue tumor with a propensity for local recurrence and occasional metastatic spread. Given its indolent course, it may be mistaken for atypical scarring or a keloid growth. Most lesions are trunkal or on the proximal extremities with digital lesions being extremely r...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-199010000-00009
更新日期:1990-10-01 00:00:00
abstract::A bayonet-shaped airway allowing free respiration and undisturbed deglutition was reconstructed in 2 young women who had undergone tracheotomy and radiotherapy for thyroid carcinoma. The laryngeal vestibule, glottis, and subglottis had been destroyed, and the air passages were closed. An external gutter and an anterio...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198605000-00010
更新日期:1986-05-01 00:00:00
abstract::Long-term follow-up of free flaps used for skull coverage in this experience has revealed that serious sequela are more likely after muscle-only free flaps. Over the past 2 decades, 8 muscle and 6 composite free flaps have been used in 12 patients. Debulking was the only secondary procedure necessary in 1 composite fl...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000123024.80566.8c
更新日期:2004-05-01 00:00:00
abstract::Ever since its introduction, the transverse rectus abdominis myocutaneous flap has become the mainstay of autologous breast reconstruction. However, concerns regarding donor site morbidity due to the breach of abdominal wall musculature integrity soon followed. Muscle-sparing techniques, eventually eliminating the mus...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000664
更新日期:2016-02-01 00:00:00
abstract::The development of sophisticated bariatric surgery techniques has led to an increasing number of patients demanding a complexity of body contouring procedures that can be achieved either with a step-by-step approach or by combining dermolipectomy in various regions. The aim of this study was to test the hypothesis tha...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000070644.58346.4A
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:Abdominal wall integrity may be compromised after abdominal flap harvest for breast reconstruction, leading to bulging or herniation due to weakening of the abdominal wall and dissection through the rectus muscle. Mesh can be used to reinforce the abdominal wall to reduce the risk of hernia formation posto...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001468
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The reported rate of isolated medial orbital wall fractures varies widely but has been found to be as high as 55% of all orbital fractures. Identifying and repairing medial orbital wall defects by using appropriate materials improves patient outcome considerably; however, most related research has focused on...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001012
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Various pedicle techniques have been described in breast reduction surgery. However, in cases of massive hypertrophy, the free nipple graft technique is still being performed by some surgeons out of fear of losing the nipple-areolar complex (NAC). As such, we evaluated patients with severe gigantomastia who ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000388
更新日期:2016-04-01 00:00:00
abstract::It has been reported that breastfeeding problems occur in women who have breast implants. The breastfeeding success of women who had augmentation with saline implants and subsequently had a live birth (n = 107) was compared with that of women of similar age who had hypoplastic breasts and had children before their con...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181c925e4
更新日期:2010-05-01 00:00:00
abstract::The most common cause of nasal obstruction is chronic enlargement of the inferior turbinate bones. The variety of medical and surgical treatments available for this condition bears testimony to their frequent ineffectiveness and the frustration of the physician or surgeon caring for these patients. Removal or destruct...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197909000-00009
更新日期:1979-09-01 00:00:00
abstract::This reconstructive microsurgery course will run yearly and was borne and popularized from its infant meeting the year before, primarily focused on perforator flaps. It is a 2-day course updating residents/registrars to attending physicians/consultants about the most topical advancements in microvascular reconstructiv...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000824
更新日期:2017-01-01 00:00:00
abstract::Pitanguy conducted a series of anatomic studies on the dermocartilaginous ligament of the nose. However, information on its structure is as yet insufficient. In addition, some of the histologic findings described by Pitanguy are controversial. The present study was undertaken to clarify the anatomy of the dermocartila...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318031c1b7
更新日期:2007-10-01 00:00:00
abstract::Oxygen free radicals are implicated to cause tissue injury during ischemia and reperfusion and may play a central role in the no-reflow phenomena. Modulation of these substances has been suggested as a means of decreasing the amount of tissue loss due to ischemia and subsequent reperfusion. Pretreatment of tissues wit...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199202000-00008
更新日期:1992-02-01 00:00:00
abstract:INTRODUCTION:Capsular contracture after breast reconstruction is a morbid complication, occurring in 30.0% to 47.5% of patients undergoing postoperative radiotherapy. Although it is well known that radiation increases rate of capsular contracture, there are few well-established animal models that faithfully replicate s...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001362
更新日期:2018-04-01 00:00:00
abstract::Clinical care is often directed at improving patient's quality of life, the effectiveness of which can be measured by objective or subjective outcomes. Surgical intervention, especially in plastic and reconstructive surgery, can often provide hard objective measures, for example, breast size reduction after bilateral ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001894
更新日期:2019-09-01 00:00:00
abstract::According to most of the literature, sutures for microarterial repair must include the intima to prevent an "intimal flap" and occlusion of the anastomosis. Some authors have said that vessel diameter affects patency rate. This study was designed to evaluate these two statements. The femoral arteries (about 1.0 mm in ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197903000-00010
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Lymphedema, a chronic disfiguring condition resulting from lymphatic dysfunction or disruption, can be difficult to accurately diagnose and manage. Of particular challenge is identifying the presence of clinically significant limb swelling through simple and noninvasive methods. Many historical and currently...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000244977.84130.cf
更新日期:2007-05-01 00:00:00
abstract::To determine the possible beneficial effect of postoperative splint immobilization after open carpal tunnel release, we performed a prospective, randomized study comparing 2 weeks of postoperative wrist splinting versus a bulky dressing only. Forty patients with 43 carpal tunnel releases were evaluated. There were no ...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000637-199507000-00004
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Ensuring that published studies are of the highest methodological quality is a critical step in plastic surgery's transition to a more evidence-based field. Reporting guidelines and reporting of clinical trial registration may serve as promising avenues of increasing the methodological quality in plastic sur...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001476
更新日期:2018-08-01 00:00:00
abstract::A Silastic tissue expander inserted subpectorally at the time of modified radical mastectomy has provided early development of the reconstructive envelope, thereby simplifying matching of the contralateral breast. Significant emotional support for the woman faced with imminent loss of her breast has been repeatedly ob...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198511000-00007
更新日期:1985-11-01 00:00:00
abstract::Augmentation and corrective malarplasty are relatively new procedures that require careful preoperative evaluation to ensure that the effect produced will blend harmoniously with the existing facial structure. A variety of implant types and materials are available to accommodate varying needs, and several surgical app...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197904000-00008
更新日期:1979-04-01 00:00:00