The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review.

Abstract:

:The management of keloids and hypertrophic scars continues to challenge health-care providers. Though both forms of pathologic scarring are distinct entities at the macro and microscopic level, their etiologies and treatment are often similar. Potential treatment approaches are progressing, and combinations of treatment options have been proposed in the literature with promising outcomes. The treatment evolution has reached a level where molecular therapeutic modalities are being investigated. Currently, no gold standard treatment exists. Overall success rates and patient satisfaction seem to be slowly climbing, but additional investigational studies must continue to be performed. Several studies have investigated antineoplastic agents, and there seems to be a marked improvement in rates of recurrence, patient satisfaction, and overall quality of scar when these agents are used. Intralesional injection and/or wound irrigation with interferon-a2b, interferon-g, mitomycin-C, bleomycin, or 5-fluorouracil seems to have a positive effect on the reduction of pathologic scars. There is mounting evidence that these drugs used alone or in combination therapy, have the potential to be an integral part of the treatment paradigm for hypertrophic scars and keloids.

journal_name

Ann Plast Surg

authors

Shridharani SM,Magarakis M,Manson PN,Singh NK,Basdag B,Rosson GD

doi

10.1097/SAP.0b013e3181afaab0

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

355-61

issue

3

eissn

0148-7043

issn

1536-3708

pii

00000637-201003000-00024

journal_volume

64

pub_type

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