Abstract：
INTRODUCTION:Abnormal synaptic pruning has been proposed by some authors as a theory to explain schizophrenia. It has been studied in different ways, some of which are computerized models. METHODS:A PC computer with MATLAB version 5.3 and Neural Networks Toolbox programs were used. To reproduce the model we used Elman's network for neuronal unit and McGlashan and Hoffman's network. RESULTS:The corrected percentage of detection improved as synapses were prunned. It increased from 68% to 91 %, reaching the highest detection level when 60% of the synapses were eliminated. Detection capacity was reduced when synaptic elimination continued and the program started detecting words in the absence of input. This was considered as a hallucination. When pruning reached from 80% to 95%, hallucinations occurred more frequently. CONCLUSIONS:The computer simulation model provides a symptom formation model, and also a way of understanding pruning's adaptative utility. When the neuronal units were eliminated (instead of connections), there was only progressive worsening in word perception. This confirms the hypothesis proposed that schizophrenia pathophysiology underlies neuronal connections, not the neurons.
journal_name
Actas Esp Psiquiatrjournal_title
Actas espanolas de psiquiatriaauthors
de la Fuente-Sandoval C,Portillo V,Fresán A,Apiquian Rsubject
Has Abstractpub_date
2005-05-01 00:00:00pages
141-6issue
3eissn
1139-9287issn
1578-2735pii
51110312journal_volume
33pub_type
杂志文章abstract：INTRODUCTION:Family influence and involvement in the obsessive- compulsive symptoms of their relatives are widely recognized in clinical practice although there is a very little research investigating those variables. The Family Accommodation (FAS) for obsessive-compulsive symptoms is an interview developed to evaluate...
journal_title：Actas espanolas de psiquiatria
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更新日期：2007-03-01 00:00:00
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journal_title：Actas espanolas de psiquiatria
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journal_title：Actas espanolas de psiquiatria
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
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journal_title：Actas espanolas de psiquiatria
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doi：
更新日期：2004-07-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Actas espanolas de psiquiatria
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journal_title：Actas espanolas de psiquiatria
pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Actas espanolas de psiquiatria
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Actas espanolas de psiquiatria
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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journal_title：Actas espanolas de psiquiatria
pub_type： 杂志文章,评审
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更新日期：2001-03-01 00:00:00
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journal_title：Actas espanolas de psiquiatria
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2000-09-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
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更新日期：1999-11-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
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journal_title：Actas espanolas de psiquiatria
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
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更新日期：2009-01-01 00:00:00
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更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-05-01 00:00:00
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journal_title：Actas espanolas de psiquiatria
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更新日期：2003-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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更新日期：2015-03-01 00:00:00
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