Abstract:
INTRODUCTION:Infection with group A Streptococcus (StrepA) can cause post-infectious sequelae, including a spectrum of childhood-onset obsessive-compulsive (OCD) and tic disorders with autoimmune origin (PANDAS, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections). Until now, no single immunological test has been designed that unequivocally diagnoses these disorders. In this study, we assessed the detection of serum antibodies against human brain enolase (AE), neural tissue (AN) and Streptococcus (AS) as a laboratory tool for the diagnosis of early-onset psychiatric disorders. METHODOLOGY:Serum antibodies against human brain enolase, total brain proteins, and total proteins from StrepA were detected by ELISA in 37 patients with a presumptive diagnosis of PANDAS and in 12 healthy subjects from Mexico and Cuba. RESULTS:The antibody titers against human brain enolase (AE) and Streptococcal proteins (AS) were higher in patients than in control subjects (t-student, tAE=-2.17, P=0.035; tAS=-2.68, P=0.01, n=12 and 37/group, df=47, significance level 0.05), while the neural antibody titers did not differ between the two groups (P(t)=0.05). The number of subjects (titers> meancontrol + CI95) with simultaneous seropositivity to all three antibodies was higher in the patient group (51.4%) than in the control group (8.3%) group (X2=5.27, P=0.022, df=1, n=49). CONCLUSIONS:The simultaneous detection of all three of these antibodies could provide valuable information for the etiologic diagnosis of individuals with early-onset obsessive-compulsive disorders associated with streptococcal infection and, consequently, for prescribing suitable therapy.
journal_name
Actas Esp Psiquiatrjournal_title
Actas espanolas de psiquiatriaauthors
Nicolini H,López Y,Genis-Mendoza AD,Manrique V,Lopez-Canovas L,Niubo E,Hernández L,Bobes MA,Riverón AM,López-Casamichana M,Flores J,Lanzagorta N,De la Fuente-Sandoval C,Santana Dsubject
Has Abstractpub_date
2015-03-01 00:00:00pages
35-41issue
2eissn
1139-9287issn
1578-2735journal_volume
43pub_type
杂志文章abstract::Since 1992 it has been reported that obsessive-compulsive behavior may emerge in patients treated with clozapine. We would like to report a case of obsessive-compulsive behavior emerging after initiation of treatment with clozapine in a 22-year-old man with a diagnosis of schizoaffective disorder that was successfully...
journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 临床试验,杂志文章,多中心研究
doi:
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abstract:INTRODUCTION:In recent years, reports of attentional deficits in schizophrenic patients and in their biological relatives have rapidly increased, including an important effort to search for the endophenotypes in order to link specific genes to this illness. Posner et al. developed a test, the Attention Network Test (AN...
journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章,评审
doi:
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章,随机对照试验
doi:
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pub_type: 杂志文章
doi:
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章,评审
doi:
更新日期:2011-09-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2019-09-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章,评审
doi:
更新日期:2005-03-01 00:00:00
abstract:INTRODUCTION:Abnormal synaptic pruning has been proposed by some authors as a theory to explain schizophrenia. It has been studied in different ways, some of which are computerized models. METHODS:A PC computer with MATLAB version 5.3 and Neural Networks Toolbox programs were used. To reproduce the model we used Elman...
journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Actas espanolas de psiquiatria
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章
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