Abstract：
OBJECTIVE:Atosiban has been shown to be an effective tocolytic agent with a low rate of side effects during 24 to 33 weeks of gestation. Atosiban acts through selective, competitive inhibition of both oxytocin and vasopressin, so that there are reasons to assume that a tocolytic effect can also be achieved earlier in the pregnancy. STUDY DESIGN:In this prospective, randomized pilot study, 20 women in the 18th through 24th week of gestation who presented at our hospital with preterm labor were treated with atosiban. In the control group 20 women received saline infusions. All patients received antibiotic therapy. A cervical cerclage was performed when indicated as was correction of the vaginal pH. RESULTS:The tocolytic effect began after 3-10 min (median: 6.5 min). Treatment time until the complete absence of contractions was 3-12 h (median: 7.5 h). Pregnancies were prolonged between 11.1 and 21.7 weeks (median: 15.6 weeks) in the atosiban group vs. 10.5-19.1 weeks in the control group. If well tolerated, atosiban was continued. There were no significant alterations in the routine laboratory parameters, circulation parameters, and fluid balance. CONCLUSION:In summary, atosiban showed itself to be effective for tocolytic treatment for premature labor, even during 18 and 24 weeks of pregnancy, while exhibiting its known, favorable profile of side effects.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Richter ON,Dorn C,van de Vondel P,Ulrich U,Schmolling Jdoi
10.1007/s00404-004-0652-8subject
Has Abstractpub_date
2005-06-01 00:00:00pages
26-30issue
1eissn
0932-0067issn
1432-0711journal_volume
272pub_type
杂志文章,随机对照试验abstract：PURPOSE:The purpose of the current study was to determine whether or not the quadruple test for screening Down syndrome is an effective method to replace direct amniocentesis in pregnant women ≥ 35 years of age. METHODS:This study analyzed the screening performance of the quadruple test according to maternal age at de...
journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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