FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.

abstract：:We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype and mutations occurring at the exon-12 of the NPM gene. In this paper, we have elu...

journal_title：Blood

authors： Falini B,Bolli N,Shan J,Martelli MP,Liso A,Pucciarini A,Bigerna B,Pasqualucci L,Mannucci R,Rosati R,Gorello P,Diverio D,Roti G,Tiacci E,Cazzaniga G,Biondi A,Schnittger S,Haferlach T,Hiddemann W,Martelli MF,Gu W,

更新日期：2006-06-01 00:00:00

abstract：:In this issue of Blood, Finn et al have taken a factor IX variant with increased specific activity associated with thrombophilia and used it to improve gene therapy of hemophilia B in dogs, and Cantore et al have shown similar results in mice. ...

journal_title：Blood

authors： Lozier JN

更新日期：2012-11-29 00:00:00

abstract：:The regulatory function of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) on granulocyte production in vivo was evaluated in an autologous bone marrow transplantation model using rhesus monkeys. Monkeys were exposed to 9.0 Gy total body irradiation and then transplanted with 5.0 x 10(7) ...

journal_title：Blood

authors： Monroy RL,Skelly RR,MacVittie TJ,Davis TA,Sauber JJ,Clark SC,Donahue RE

更新日期：1987-11-01 00:00:00

abstract：:T-cell alloreactivity directed against non-self-HLA molecules has been assumed to be less peptide specific than conventional T-cell reactivity. A large variation in degree of peptide specificity has previously been reported, including single peptide specificity, polyspecificity, and peptide degeneracy. Peptide polyspe...

journal_title：Blood

authors： Amir AL,van der Steen DM,Hagedoorn RS,Kester MG,van Bergen CA,Drijfhout JW,de Ru AH,Falkenburg JH,van Veelen PA,Heemskerk MH

更新日期：2011-12-22 00:00:00

abstract：:We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

journal_title：Blood

authors： Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

更新日期：2010-01-28 00:00:00

abstract：:Hematologic engraftment and immune reconstitution were examined in patients who received cyclophosphamide and total body irradiation therapy followed by infusion of autologous bone marrow purged with anti-B1 monoclonal antibody (MoAb) and complement as therapy for non-Hodgkin's lymphoma. Hematologic engraftment was pr...

journal_title：Blood

authors： Anderson KC,Ritz J,Takvorian T,Coral F,Daley H,Gorgone BC,Freedman AS,Canellos GP,Schlossman SF,Nadler LM

更新日期：1987-02-01 00:00:00

abstract：:Chronic infection with Schistosoma mansoni induces in humans and mice a Th2-dominant immune response in which eosinophils and IgE are conspicuously elevated. Human eosinophils express IgE receptors that participate in an IgE-dependent eosinophil-mediated ADCC reaction against Schistosomula larvae in vitro. To investig...

journal_title：Blood

authors： de Andres B,Rakasz E,Hagen M,McCormik ML,Mueller AL,Elliot D,Metwali A,Sandor M,Britigan BE,Weinstock JV,Lynch RG

更新日期：1997-05-15 00:00:00

abstract：:We investigated 17 patients (12 males and 5 females, ages 2 to 57 years old) with posttransfusion non-A, non-B hepatitis to determine relationships between clinical courses and hepatitis C virus (HCV) markers. The patients were grouped according to time course of abnormal serum alanine aminotransferase (ALT) levels in...

journal_title：Blood

authors： Shibata M,Morishima T,Kudo T,Maki T,Maki S,Nagai Y

更新日期：1991-03-15 00:00:00

abstract：:We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) stimulate the differentiation of human monocytes into two phenotypically distinct types of macrophages. However, in vivo, not only CSF but also many other cytokines are produced under va...

journal_title：Blood

authors： Akagawa KS,Takasuka N,Nozaki Y,Komuro I,Azuma M,Ueda M,Naito M,Takahashi K

更新日期：1996-11-15 00:00:00

abstract：:Primary myelofibrosis (PMF) is the most serious myeloproliferative disorder, characterized by clonal myeloproliferation associated with cytokine-mediated bone marrow stromal reaction including fibrosis and osteosclerosis. Current drug therapy remains mainly palliative. Because the NF-kappaB pathway is implicated in th...

journal_title：Blood

authors： Wagner-Ballon O,Pisani DF,Gastinne T,Tulliez M,Chaligné R,Lacout C,Auradé F,Villeval JL,Gonin P,Vainchenker W,Giraudier S

更新日期：2007-07-01 00:00:00

abstract：:There is growing evidence that lymphocyte trafficking contributes to the clinical course of chronic lymphocytic leukemia (CLL), but to date, only static in vitro cultures have been used to study these phenomena. To address this lack of data, we have developed a dynamic in vitro model in which CLL cells experience shea...

journal_title：Blood

authors： Walsby E,Buggins A,Devereux S,Jones C,Pratt G,Brennan P,Fegan C,Pepper C

更新日期：2014-06-05 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) are associated with susceptibility to different immune and nonimmune mediated diseases. We had reported that the drug adverse reaction, clozapine-induced agranulocytosis (CA), is associated with different HLA types and HSP70 variants in Ashkenazi Jewish and non-Jewis...

journal_title：Blood

authors： Turbay D,Lieberman J,Alper CA,Delgado JC,Corzo D,Yunis JJ,Yunis EJ

更新日期：1997-06-01 00:00:00

abstract：:Surrogate light chain expression during B lineage differentiation was examined by using indicator fluorochrome-filled liposomes in an enhanced immunofluorescence assay. Pro-B cells bearing surrogate light chain components were found in mice, but not in humans. A limited subpopulation of relatively large pre-B cells in...

journal_title：Blood

authors： Wang YH,Stephan RP,Scheffold A,Kunkel D,Karasuyama H,Radbruch A,Cooper MD

更新日期：2002-04-01 00:00:00

abstract：:Mammalian 15-lipoxygenases, which have been implicated in the differentiation of hematopoietic cells are commonly regarded as cytosolic enzymes. Studying the interaction of the purified rabbit reticulocyte 15-lipoxygenase with various types of biomembranes, we found that the enzyme binds to biomembranes when calcium i...

journal_title：Blood

authors： Brinckmann R,Schnurr K,Heydeck D,Rosenbach T,Kolde G,Kühn H

更新日期：1998-01-01 00:00:00

abstract：:An animal model for malignant mastocytosis is described in mice reconstituted with bone marrow cells expressing the v-erbB oncogene. The lethal mast cell disease is characterized by massive infiltration of bone marrow, spleen, and several other visceral organs by connective tissue mast cells, which normally reside in ...

journal_title：Blood

authors： von Rüden T,Kandels S,Radaszkiewicz T,Ullrich A,Wagner EF

更新日期：1992-06-15 00:00:00

abstract：:CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable proportion of human neutrophils that mediates surface expression of the antineutrophil cytoplasmic antibody antigen proteinase 3. CD177 associates with β2 integrins and recognizes platelet endothelial cell adhesion molecule 1 (PECAM...

journal_title：Blood

authors： Bai M,Grieshaber-Bouyer R,Wang J,Schmider AB,Wilson ZS,Zeng L,Halyabar O,Godin MD,Nguyen HN,Levescot A,Cunin P,Lefort CT,Soberman RJ,Nigrovic PA

更新日期：2017-11-09 00:00:00

abstract：:To study outcomes of adults with idiopathic thrombocytopenic purpura (ITP), we performed a follow-up study in a cohort of 152 consecutive patients who were treated according to a well-defined algorithm. Long-term outcomes were determined relative to the response 2 years after diagnosis, because most (93%) patients who...

journal_title：Blood

authors： Portielje JE,Westendorp RG,Kluin-Nelemans HC,Brand A

更新日期：2001-05-01 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) is an increasingly common cause of morbidity and mortality in allogeneic stem cell transplantation (alloSCT). Relative to acute GVHD (aGVHD), much less is understood about cGVHD. Using the B10.D2 --> BALB/c murine cGVHD model, which shares critical pathologic features with hum...

journal_title：Blood

authors： Anderson BE,McNiff JM,Matte C,Athanasiadis I,Shlomchik WD,Shlomchik MJ

更新日期：2004-09-01 00:00:00

abstract：:Eosinophils are involved in the inflammatory response seen in allergy and helminthic infestations. Eosinophils synthesize transforming growth factor-alpha (TGF-alpha), which may play a role in the development of the characteristic fibrosis seen in longstanding high eosinophilia. Using immunoelectron microscopic techni...

journal_title：Blood

authors： Egesten A,Calafat J,Knol EF,Janssen H,Walz TM

更新日期：1996-05-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207(+) dendritic cells with an inflammatory infiltrate. BRAFV600E remains the only recurrent mutation reported in LCH. In order to evaluate the spectrum of somatic mutations in LCH, whole exome sequ...

journal_title：Blood

authors： Chakraborty R,Hampton OA,Shen X,Simko SJ,Shih A,Abhyankar H,Lim KP,Covington KR,Trevino L,Dewal N,Muzny DM,Doddapaneni H,Hu J,Wang L,Lupo PJ,Hicks MJ,Bonilla DL,Dwyer KC,Berres ML,Poulikakos PI,Merad M,McClain K

更新日期：2014-11-06 00:00:00

abstract：:Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic c...

journal_title：Blood

authors： Melemed AS,Ryder JW,Vik TA

更新日期：1997-11-01 00:00:00

abstract：:Indolent systemic mastocytosis (SM) patients have a varied clinical presentation, ranging from predominantly cutaneous symptoms to recurrent systemic symptoms (eg, flushing, palpitations, dyspepsia, diarrhea, bone pain) that can be severe and potentially life threatening (anaphylaxis). Mastocytosis patients without sk...

journal_title：Blood

authors： Pardanani A

更新日期：2013-04-18 00:00:00

abstract：:A 42-yr-old woman with systemic lupus erythematosus without bleeding diathesis developed a prolonged activated partial thromboplastin time that was not corrected by normal plasma. An inhibitor that acted rapidly and inactivated 0.5 U/ml plasma thromboplastin antecedent (PTA, factor XI) at a 1:200 plasma dilution was d...

journal_title：Blood

authors： Poon MC,Saito H,Koopman WJ

更新日期：1984-06-01 00:00:00

abstract：:Platelets play a crucial role in the physiology of primary hemostasis and pathophysiologic processes such as arterial thrombosis. Accumulating evidence suggests a role of reactive oxygen species (ROSs) in platelet activation. Here we show that platelets activated with different agonists produced intracellular ROSs, wh...

journal_title：Blood

authors： Begonja AJ,Gambaryan S,Geiger J,Aktas B,Pozgajova M,Nieswandt B,Walter U

更新日期：2005-10-15 00:00:00

abstract：:Human umbilical vein endothelial cells were analyzed for the presence of prothrombin, factor VII, protein C, and protein S in culture supernatants and cell extracts using specific radioimmunoassays. Only protein S was detected. Conditioned medium from 24-hour cultures and cell lysates contained 21.7 ng/mL and 88.8 ng/...

journal_title：Blood

authors： Fair DS,Marlar RA,Levin EG

更新日期：1986-04-01 00:00:00

abstract：:The number of neutrophils in the blood is tightly regulated to ensure adequate protection against microbial pathogens while minimizing damage to host tissue. Neutrophil homeostasis in the blood is achieved through a balance of neutrophil production, release from the bone marrow, and clearance from the circulation. Acc...

journal_title：Blood

authors： Eash KJ,Means JM,White DW,Link DC

更新日期：2009-05-07 00:00:00

abstract：:The success of allogeneic hematopoietic cell transplantation depends heavily on the delicate balance between the activity of the donor immune system against malignant and nonmalignant cells of the recipient. Abrogation of alloreactivity will lead to disease relapse, whereas untamed allo-immune responses will lead to l...

journal_title：Blood

authors： Voermans C,Hazenberg MD

更新日期：2020-07-23 00:00:00

abstract：:The localization of memory T cells to human skin is essential for long-term immune surveillance and the maintenance of barrier integrity. Although the mechanisms controlling memory T-cell migration to peripheral tissues are poorly understood, the current paradigm includes the localized secretion of "imprinting" signal...

journal_title：Blood

authors： McCully ML,Ladell K,Hakobyan S,Mansel RE,Price DA,Moser B

更新日期：2012-11-29 00:00:00

abstract：:Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence...

journal_title：Blood

authors： Kundu M,Lindsten T,Yang CY,Wu J,Zhao F,Zhang J,Selak MA,Ney PA,Thompson CB

更新日期：2008-08-15 00:00:00

abstract：:The stages of human natural killer (NK) cell differentiation are not well established. Culturing CD34(+) progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT-3L, and murine fetal liver cell line (EL08.1D2), we identified 2 nonoverlapping subsets of differentiating CD56(+) cells based on CD117 and ...

journal_title：Blood

authors： Grzywacz B,Kataria N,Sikora M,Oostendorp RA,Dzierzak EA,Blazar BR,Miller JS,Verneris MR

更新日期：2006-12-01 00:00:00