Increase of sexually transmitted infections, but not HIV, among young homosexual men in Amsterdam: are STIs still reliable markers for HIV transmission?

Abstract:

OBJECTIVES:The incidence of HIV and STIs increased among men who have sex with men (MSM) visiting our STI clinic in Amsterdam. Interestingly, HIV increased mainly among older (> or =35 years) MSM, whereas infection rates of rectal gonorrhoea increased mainly in younger men. To explore this discrepancy we compared trends in STIs and HIV in a cohort of young HIV negative homosexual men from 1984 until 2002. METHODS:The study population included 863 men enrolled at < or =30 years of age from 1984 onward in the Amsterdam Cohort Studies (ACS). They had attended at least one of the 6 monthly follow up ACS visits at which they completed a questionnaire (including self reported gonorrhoea and syphilis episodes) and were tested for syphilis and HIV. Yearly trends in HIV and STI incidence and risk factors were analysed using Poisson regression. RESULTS:Mean age at enrollment was 25 years. The median follow up time was 4 years. Until 1995 trends in HIV and STI incidence were concurrent, however since 1995 there was a significant (p<0.05) increase in syphilis (0 to 1.4/100 person years (PY)) and gonorrhoea incidence (1.1 to 6.0/100 PY), but no change in HIV incidence (1.1 and 1.3/100 PY). CONCLUSIONS:The incidence of syphilis and gonorrhoea has increased among young homosexual men since 1995, while HIV incidence has remained stable. Increasing STI incidence underscores the potential for HIV spread among young homosexual men. However, several years of increasing STIs without HIV, makes the relation between STI incidence and HIV transmission a subject for debate.

journal_name

Sex Transm Infect

authors

van der Bij AK,Stolte IG,Coutinho RA,Dukers NH

doi

10.1136/sti.2003.007997

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

34-7

issue

1

eissn

1368-4973

issn

1472-3263

pii

81/1/34

journal_volume

81

pub_type

杂志文章
  • Trichomonas vaginalis, endometritis and sequelae among women with clinically suspected pelvic inflammatory disease.

    abstract:OBJECTIVE:To ascertain the prevalence of Trichomonas vaginalis and investigate associations between trichomoniasis, endometritis and sequelae among women with pelvic inflammatory disease (PID). METHODS:We assessed the prevalence of trichomoniasis identified via wet mount and its association with histologically confirm...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2019-054079

    authors: Wiringa AE,Ness RB,Darville T,Beigi RH,Haggerty CL

    更新日期:2020-09-01 00:00:00

  • Predictors of provider recommendation for HPV vaccine among young adult men and women: findings from a cross-sectional survey.

    abstract:BACKGROUND:Although physician recommendation is one of the strongest predictors of human papillomavirus (HPV) vaccination, it is unclear for whom physicians are recommending the vaccine. To help guide intervention efforts, this study investigated predictors of participant-reported physician recommendation for HPV vacci...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052088

    authors: Gerend MA,Shepherd MA,Lustria ML,Shepherd JE

    更新日期:2016-03-01 00:00:00

  • Rectal chlamydia--a reservoir of undiagnosed infection in men who have sex with men.

    abstract:OBJECTIVE:To determine the prevalence of rectal chlamydia infection in a cohort of men who have sex with men (MSM) and the proportion of infection that would be missed without routine screening. METHODS:MSM presenting to four HIV/GUM outpatient clinics at the Chelsea & Westminster Hospital NHS Foundation Trust between...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2008.031773

    authors: Annan NT,Sullivan AK,Nori A,Naydenova P,Alexander S,McKenna A,Azadian B,Mandalia S,Rossi M,Ward H,Nwokolo N

    更新日期:2009-06-01 00:00:00

  • The descriptive epidemiology of male sex workers in Pakistan: a biological and behavioural examination.

    abstract:OBJECTIVES:There is a dearth of published information on the characteristics of sex workers in Pakistan. This study sought to characterise and compare hijra and non-hijra sex workers from eight large cities in Pakistan. DESIGN:χ(2) and Kruskal-Wallis tests, and multivariable logistic regression were used where appropr...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.041335

    authors: Shaw SY,Emmanuel F,Adrien A,Holte-McKenzie M,Archibald CP,Sandstrom P,Blanchard JF

    更新日期:2011-02-01 00:00:00

  • Surveillance of HIV in the army of the Republic of Cyprus (SHARC); rationale, design, and implementation of an inexpensive system.

    abstract:OBJECTIVES:To design and implement an HIV surveillance system using periodic cross sectional prevalence surveys in National Guard recruits of the Republic of Cyprus. METHODS:HIV infection surveillance used unlinked anonymous screening (UAS) methodology, which tested residual blood originally collected for other purpos...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.1.50

    authors: Kyriakides T,Eleftheriou A,Michaelides N,Papantoniou L

    更新日期:2002-02-01 00:00:00

  • Comprehensive testing for, and diagnosis of, sexually transmissible infections among Australian gay and bisexual men: findings from repeated, cross-sectional behavioural surveillance, 2003-2012.

    abstract:OBJECTIVES:To analyse changes in testing for sexually transmissible infections (STI) among gay and bisexual men in Melbourne, Sydney and Queensland, Australia, particularly comprehensive STI testing (at least four tests from different anatomical sites in the previous year), and the characteristics of men who had such t...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2013-051294

    authors: Holt M,Hull P,Lea T,Guy R,Bourne C,Prestage G,Zablotska I,de Wit J,Mao L

    更新日期:2014-05-01 00:00:00

  • A double-edged sword: does highly active antiretroviral therapy contribute to syphilis incidence by impairing immunity to Treponema pallidum?

    abstract:BACKGROUND AND HYPOTHESIS:Recently, the world has experienced a rapidly escalating outbreak of infectious syphilis primarily affecting men who have sex with men (MSM); many are taking highly active antiretroviral therapy (HAART) for HIV-1 infection. The prevailing hypothesis is that HAART availability and effectiveness...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sextrans-2016-052870

    authors: Rekart ML,Ndifon W,Brunham RC,Dushoff J,Park SW,Rawat S,Cameron CE

    更新日期:2017-08-01 00:00:00

  • Prevalence, incidence and associated risk factors of STIs during pregnancy in South Africa.

    abstract:OBJECTIVE:STIs during pregnancy increase adverse pregnancy and birth outcomes and may increase HIV risk. STI syndromic management is standard of care in South Africa. Our study evaluated the prevalence and incidence of STIs in pregnant women and the associated risk factors. METHODS:We combined data from two prospectiv...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2020-054631

    authors: Nyemba DC,Medina-Marino A,Peters RPH,Klausner JD,Ngwepe P,Myer L,Johnson LF,Davey DJ

    更新日期:2020-10-01 00:00:00

  • Prevalence and clinical characteristics of patients with biologically false-positive reactions with serological syphilis testing in contemporary practice: 10-year experience at a tertiary academic hospital.

    abstract:OBJECTIVES:Biologically false positive (BFP) reactions are well described in early literature. However, only a few recent reports described the incidence and clinical characteristics of patients with BFP reactions. We reviewed the serological test results of patients tested for syphilis in our hospital in the past deca...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2020-054628

    authors: Ishihara Y,Okamoto K,Shimosaka H,Ono Y,Kanno Y,Ikeda M,Harada S,Kurano M,Okugawa S,Moriya K,Yatomi Y

    更新日期:2020-11-18 00:00:00

  • Can we improve partner notification rates through expedited partner therapy in the UK? Findings from an exploratory trial of Accelerated Partner Therapy (APT).

    abstract:OBJECTIVES:To develop two new models of expedited partner therapy for the UK, and evaluate them for feasibility, acceptability and preliminary outcome estimates to inform the design of a randomised controlled trial (RCT). METHODS:Two models of expedited partner therapy (APTHotline and APTPharmacy), known as 'Accelerat...

    journal_title:Sexually transmitted infections

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/sti.2010.047258

    authors: Estcourt C,Sutcliffe L,Cassell J,Mercer CH,Copas A,James L,Low N,Horner P,Clarke M,Symonds M,Roberts T,Tsourapas A,Johnson AM

    更新日期:2012-02-01 00:00:00

  • Investigating ethnic differences in sexual health: focus groups with young people.

    abstract:OBJECTIVES:To compare normative beliefs about sexual health in young men and women from black Caribbean, black African, and white ethnic groups in order to better understand ethnic inequalities in sexual health. METHODS:Focus group discussions with young people living in an area with known high prevalence of gonorrhoe...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2003.005181

    authors: Connell P,McKevitt C,Low N

    更新日期:2004-08-01 00:00:00

  • New sexually transmitted infections among adolescent girls infected with HIV.

    abstract:OBJECTIVES:Although the prevalence of sexually transmitted infections (STIs) among girls infected with HIV has been reported, the incidence of STI diagnoses has not been well documented. The objectives of this study were to examine (1) incident STI diagnoses and (2) the association between viral load (VL) and incident ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2007.026161

    authors: Trent M,Chung SE,Ellen JM,Clum G,Adolescent HIV\/AIDS Trials Network.

    更新日期:2007-10-01 00:00:00

  • Changes in high-risk sexual behaviour among Estonian adults between 1996 and 2006.

    abstract:OBJECTIVE:To describe and compare sexual behaviour patterns in 1996 (before the explosion of the HIV epidemic in 2000) and 2006, and the correlates of high-risk sexual behaviour in Estonia. METHODS:Data on selected sexual behaviour characteristics were obtained by interviewing a probability sample of the adult populat...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050506

    authors: Liivlaid H,Uusküla A

    更新日期:2013-03-01 00:00:00

  • In search of optimal genital herpes management and standard of care (INSIGHTS): doctors' and patients' perceptions of genital herpes.

    abstract:OBJECTIVE:To compare and contrast attitudes and behaviours of family doctors and patients with regard to genital herpes and its management. METHODS:Family doctors and infected patients were surveyed online to explore disease importance/seriousness, emotional impact, transmission and treatment. The study received ethic...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2007.027631

    authors: Romanowski B,Zdanowicz YM,Owens ST

    更新日期:2008-02-01 00:00:00

  • What is the overlap between HIV and shigellosis epidemics in England: further evidence of MSM transmission?

    abstract:BACKGROUND:Evidence suggests that sexual transmission between men has replaced foreign travel as the predominant mode of Shigella transmission in England. However, sexuality and HIV status are not routinely recorded for laboratory-reported Shigella, and the role of HIV in the Shigella epidemic is not well understood. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2016-052962

    authors: Mohan K,Hibbert M,Rooney G,Canvin M,Childs T,Jenkins C,Simms I,Kirwan P,Delpech V,Yin Z,Hughes G,Field N

    更新日期:2018-02-01 00:00:00

  • High levels of unprotected anal intercourse and never testing for HIV among men who have sex with men in Nigeria: evidence from a cross-sectional survey for the need for innovative approaches to HIV prevention.

    abstract:OBJECTIVES:To describe sexual risk behaviour, correlates of unprotected anal intercourse (UAI) and never testing for HIV and its implications for HIV prevention interventions among men who have sex with men (MSM) in Nigeria and other similar contexts. METHODS:A cross-sectional survey was administered to 712 MSM in Abu...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2013-051065

    authors: Vu L,Andrinopoulos K,Tun W,Adebajo S

    更新日期:2013-12-01 00:00:00

  • Implications of current recommendations for third-generation cephalosporin use in the WHO Western Pacific Region following the emergence of multiresistant gonococci.

    abstract::To ascertain recommendations for the treatment of gonorrhoea in the WHO Western Pacific Region (WPR) following the emergence of "cephalosporin-resistant" Neisseria gonorrhoeae and to relate these to clinical and laboratory measures directed towards disease and antibiotic resistance control. WHO WPR Gonococcal Antimicr...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2008.035337

    authors: Tapsall JW

    更新日期:2009-08-01 00:00:00

  • The superiority of polymerase chain reaction over an amplified enzyme immunoassay for the detection of genital chlamydial infections.

    abstract:BACKGROUND/OBJECTIVES:The polymer conjugate enhanced enzyme immunoassay (IDEIA) and Cobas Amplicor polymerase chain reaction Chlamydia trachomatis (CT) (Amplicor PCR) are two commonly used assays for the diagnosis of CT infection. The performance of these assays was compared for the diagnosis of genital CT infection am...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.015362

    authors: Jalal H,Stephen H,Al-Suwaine A,Sonnex C,Carne C

    更新日期:2006-02-01 00:00:00

  • A survey of the use of text messaging for communication with partners in the process of provider-led partner notification.

    abstract:OBJECTIVES:Partner notification (PN) is important for sexually transmitted infection (STI) control. With developments in technology, such as text messaging, contacting partners is now easier. This study investigates the frequency and acceptability of text messaging in UK sexual health clinics for STI provider-led PN. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2014-051701

    authors: Gilbart VL,Town K,Lowndes CM

    更新日期:2015-03-01 00:00:00

  • The epidemiology of ciprofloxacin resistant isolates of Neisseria gonorrhoeae in Scotland 2002: a comparison of phenotypic and genotypic analysis.

    abstract:OBJECTIVES:To characterise all isolates with reduced susceptibility or resistance to ciprofloxacin received by the Scottish Neisseria gonorrhoeae Reference Laboratory (SNGRL) in 2002 using N gonorrhoeae multi-antigen sequence typing (NG-MAST); to compare NG-MAST with conventional typing and to describe the epidemiology...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2004.013565

    authors: Palmer HM,Young H,Martin IM,Ison CA,Spratt BG

    更新日期:2005-10-01 00:00:00

  • Health economic methodology illustrated with recent work on Chlamydia screening: the concept of extended dominance.

    abstract::The health economic concepts of dominance were reviewed on the basis of two recently published cost-effectiveness analyses on screening for asymptomatic Chlamydia trachomatis, one in this journal. On the basis of dominance, some strategies may be deleted from the set options from which to choose. The two investigated ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2007.028043

    authors: Postma MJ,de Vries R,Welte R,Edmunds WJ

    更新日期:2008-04-01 00:00:00

  • Comparison of risk factors for four sexually transmitted infections: results from a study of attenders at three genitourinary medicine clinics in England.

    abstract:OBJECTIVE:To compare the risk factors for four common sexually transmitted infections (STIs) in attenders at three large urban genitourinary medicine (GUM) clinics in England. METHODS:Clinical, demographic, and behavioural data on attenders at two clinics in London and one in Sheffield were collected. Risk factors ass...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.76.4.262

    authors: Hughes G,Catchpole M,Rogers PA,Brady AR,Kinghorn G,Mercey D,Thin N

    更新日期:2000-08-01 00:00:00

  • Migrant men: a priority for HIV control in Pakistan?

    abstract:OBJECTIVES:To assess sexual risk behaviour and prevalence of treatable sexually transmitted infections (STI) in migrant male workers in Lahore, Pakistan. METHODS:Behavioural interviews were conducted on a representative sample of 590 migrant men aged 20-49 years. Biological samples were collected from a subsample of 1...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.018762

    authors: Faisel A,Cleland J

    更新日期:2006-08-01 00:00:00

  • STI epidemics in the Indian Ocean region: can the phase be assessed?

    abstract::The Indian Ocean provides a unique opportunity to curb the HIV epidemic in its nascent phase through strengthening STI control programmes. Making effective and appropriate health services available should be regarded as the first priority for STI control in the region and, whenever possible, core groups should be iden...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.suppl_1.i121

    authors: Matteelli A,Pizzocolo C,Bakar HA,Toyb M,Pyndiah N,Udonwa NE,Gedeon AG,Farina C,Caligaris S,Castelli F,Carosi G

    更新日期:2002-04-01 00:00:00

  • Syndromic approach to STD case management: where do we go from here?

    abstract::In the absence of aetiological tests for the diagnosis of individual sexually transmitted diseases (STD), the syndromic approach has been developed as an effective and appropriate case management strategy. Algorithms provide guidance to healthcare workers and ensure standardised approaches to case management. The synd...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:

    authors: van Dam CJ,Becker KM,Ndowa F,Islam MQ

    更新日期:1998-06-01 00:00:00

  • Spontaneous clearance of urogenital, anorectal and oropharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae in women, MSM and heterosexual men visiting the STI clinic: a prospective cohort study.

    abstract:OBJECTIVE:Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections can clear without treatment. Despite high prevalence of anorectal infections in men who have sex with men (MSM) and women, studies on anorectal clearance are scarce. Moreover it is unknown whether bacterial load affects urogenital/anorectal ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2018-053825

    authors: van Liere GAFS,Hoebe CJPA,Dirks JA,Wolffs PF,Dukers-Muijrers NHTM

    更新日期:2019-11-01 00:00:00

  • Acute hepatitis A infection after hepatitis A immunity in a HIV-positive individual.

    abstract::Hepatitis A is a self-limiting infection caused by the hepatitis A virus (HAV), transmitted predominantly by the faecal-oral route including some sexual practices. Outbreaks are commonly reported in the men who have sex with men (population. Previous exposure is thought to provide life-long immunity against subsequent...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2017-053246

    authors: Lee MJ,Douthwaite S,Kulasegaram R

    更新日期:2018-02-01 00:00:00

  • Markers of local immunity in cervico-vaginal secretions of HIV infected women: implications for HIV shedding.

    abstract:OBJECTIVES:To link local proinflammatory cytokines with HIV related nucleic acids in cervico-vaginal secretions and the factors associated with them. METHODS:An observational study on 60 HIV positive women attending the department of obstetrics and gynaecology, University of Pavia, Italy. HIV-1 RNA in plasma, proviral...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2003.005157

    authors: Zara F,Nappi RE,Brerra R,Migliavacca R,Maserati R,Spinillo A

    更新日期:2004-04-01 00:00:00

  • The association between gang involvement and sexual behaviours among detained adolescent males.

    abstract:OBJECTIVE:Data were collected from 270 detained male adolescents (aged 14-18 years) to determine the association between ever having been in a gang and a range of sexual behaviours such as sexual activity, male condom use, sex with multiple partners, and drug use during sex. METHODS:Participants answered survey questi...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2004.010926

    authors: Voisin DR,Salazar LF,Crosby R,DiClemente RJ,Yarber WL,Staples-Horne M

    更新日期:2004-12-01 00:00:00

  • Patterns and trends in Pakistan's heterogeneous HIV epidemic.

    abstract:BACKGROUND:Considerable HIV transmission occurs among injection drug users (IDUs) in Pakistan and recently the HIV prevalence has been increasing among male (MSW), hijra (transgender; HSW) and female (FSW) sex workers. We describe past and estimate future patterns of HIV emergence among these populations in several cit...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050872

    authors: Reza T,Melesse DY,Shafer LA,Salim M,Altaf A,Sonia A,Jayaraman GC,Emmanuel F,Thompson LH,Blanchard JF

    更新日期:2013-09-01 00:00:00