Abstract:
OBJECTIVE:To ascertain the prevalence of Trichomonas vaginalis and investigate associations between trichomoniasis, endometritis and sequelae among women with pelvic inflammatory disease (PID). METHODS:We assessed the prevalence of trichomoniasis identified via wet mount and its association with histologically confirmed endometritis, infertility and recurrent PID among 647 women in the PID Evaluation and Clinical Health (PEACH) study. Participants were treated for clinically suspected PID and followed for a mean of 84 months for incident sequelae. Analyses were adjusted for age, race, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and bacterial vaginosis. Additional adjustments were incorporated for history of infertility (models of pregnancy and infertility), history of PID (recurrent PID), and self-reported partner treatment and intercourse between baseline and 30-day follow-up (persistent endometritis). RESULTS:T. vaginalis was present in the vagina of 12.8% of women. The odds of having endometritis at baseline were twice as high among women with trichomoniasis as compared with those without (adjusted OR (AOR): 1.9, 95% CI 1.0 to 3.3). Persistent endometritis was highly prevalent at 30 days (52.1%) and more common among women with baseline trichomoniasis (AOR: 2.6, 95% CI 0.7 to 10.1), although non-significantly. Infertility and recurrent PID were more common among women with trichomoniasis, while rates of pregnancy and live birth were lower. CONCLUSIONS:T. vaginalis was frequently isolated from the vagina of women with PID in the PEACH cohort. Wet mount microscopy for the identification of motile trichomonads was standard practice at the time of the PEACH study, but likely resulted in an underestimation of true T. vaginalis prevalence. Our findings of modest, although non-significant, prospective associations between trichomoniasis and sequelae are novel and underscore the need for additional investigation into whether T. vaginalis may play an aetiological role in adverse reproductive and gynaecological outcomes.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Wiringa AE,Ness RB,Darville T,Beigi RH,Haggerty CLdoi
10.1136/sextrans-2019-054079subject
Has Abstractpub_date
2020-09-01 00:00:00pages
436-438issue
6eissn
1368-4973issn
1472-3263pii
sextrans-2019-054079journal_volume
96pub_type
杂志文章abstract:OBJECTIVES:To determine the prevalence of urethritis pathogens amongst male symptomatic urethritis (MUS) patients, genital ulcer (GUS) patients without urethritis symptoms and men requesting HIV testing at a voluntary counselling and testing (VCT) clinic. METHODS:A prospective study was conducted in Johannesburg, Sout...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2007.028464
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Measuring clinical performance within a framework of clinical governance is increasingly important for monitoring improvements in patient care. Standards for quality indicators must, however, be achievable and evidence based. We describe an approach to the development of national standards for measuring outc...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.2003.005165
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:Biologically false positive (BFP) reactions are well described in early literature. However, only a few recent reports described the incidence and clinical characteristics of patients with BFP reactions. We reviewed the serological test results of patients tested for syphilis in our hospital in the past deca...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054628
更新日期:2020-11-18 00:00:00
abstract:OBJECTIVES:As the global HIV pandemic enters its fourth decade, countries have collected longer time series of surveillance data, and the AIDS-specific mortality has been substantially reduced by the increasing availability of antiretroviral treatment. A refined model with a greater flexibility to fit longer time serie...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050689
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:Men who have sex with men (MSM) living with HIV are at high risk of infection with high-risk human papillomavirus (HPV), the cause of anal cancer. We assess whether anal HPV DNA detection is related to recent anal sexual activity, what types of anal sexual activity or the persistence of HPV genotypes. METHO...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2015-052121
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:The Sydney Sexual Health Centre in Australia uses a proforma tool to screen all new female clients for recent physical intimate partner violence (IPV). This study describes the prevalence and associations of recent physical IPV among women attending a sexual health clinic. METHOD:The clinic database was use...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.043109
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To design and implement an HIV surveillance system using periodic cross sectional prevalence surveys in National Guard recruits of the Republic of Cyprus. METHODS:HIV infection surveillance used unlinked anonymous screening (UAS) methodology, which tested residual blood originally collected for other purpos...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.1.50
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To examine the policy and practice of HIV testing in genitourinary medicine clinics in the United Kingdom. DESIGN:All 176 consultants in charge of genitourinary medicine clinics in the United Kingdom were sent a policy and practice questionnaire. A self selected group of 53 clinics conducted a retrospective...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.76.4.307
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVES:Sexually transmitted infections (STI) and bacterial vaginosis (BV) cause female genital tract inflammation. This inflammation, which is often present in the absence of symptoms, is associated with increased susceptibility to HIV infection. We aimed to evaluate genital cytokine profiles and the degree of infl...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2014-051601
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:From December 2017, the Australian National Cervical Screening Program commenced 5 yearly primary human papillomavirus (HPV) screening; one of the first high-income countries to implement primary HPV screening. This study aimed to examine the psychosocial impact of self-reporting testing HPV positive in a sam...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2019-054290
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To investigate the impact of a health adviser in genitourinary medicine as a training and support resource on the management of Chlamydia trachomatis in a large inner city health centre. METHODS:A large, inner city health centre was selected at random for the intervention, with another selected as control. ...
journal_title:Sexually transmitted infections
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/sti.79.5.369
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:To undertake the first comprehensive analysis of the incidence of three curable sexually transmissible infections (STIs) within remote Australian Aboriginal populations and provide a basis for developing new control initiatives. METHODS:We obtained all results for Chlamydia trachomatis (CT), Neisseria gonor...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2014-051617
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To estimate the predictive values for HIV infection of diagnosis of oral manifestations of the infection. METHOD:Prevalence of oral manifestations was compared in cross sectional blinded clinical examinations of homosexual men attending a genitourinary medicine clinic. Data were extrapolated to populations i...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.74.5.345
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To identify risk factors for pelvic inflammatory disease (PID) in female students. METHODS:We performed a prospective study set in 11 universities and 9 further education colleges in London. In 2004-2006, 2529 sexually experienced, multiethnic, female students, mean age 20.8 years, provided self-taken vagina...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2015-052063
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Millions of patients are prescribed drugs for sexually transmitted infections (STIs) in developing countries each year, yet the treatment effect of these prescriptions is largely unknown. OBJECTIVES:To determine if the prescribing of erythromycin and ceftriaxone to pregnant women with STI symptoms leads to ...
journal_title:Sexually transmitted infections
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/sti.2003.007757
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVES:To investigate local cellular immune responses in patients with acute urethritis. METHODS:We have established T cell lines from the urethral exudate and examined their phenotype by flow cytometry. As controls, T cell lines were cultured from first pass urine specimens of asymptomatic healthy individuals. R...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.74.4.279
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To determine the characteristics of general practitioners (GPs) who test and patients who are tested for HIV in Australia. DESIGN AND SETTING:A secondary analysis of data from the Bettering the Evaluation and Care of Health programme; a cross-sectional, national survey of GP activity. METHODS:We identified ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2011.049601
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Intravaginal practices including vaginal washing have been associated with HIV-1 acquisition. This association may be mediated by mucosal disruption, changes in vaginal flora or genital tract inflammatory responses. Reducing vaginal washing could lower women's risk of HIV-1 acquisition. METHODS:23 HIV-1 ser...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050564
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:HIV transmission is ongoing among men who have sex with men (MSM) in the UK. Sex without a condom (condomless sex, CLS) is the main risk factor. We investigated the prevalence of and factors associated with types of CLS. METHODS:Cross-sectional questionnaire study in UK HIV clinics in 2011/2012 (ASTRA). MSM ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2016-053029
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:To describe the mode of presentation, interventions, and outcome of HIV infected patients with pulmonary embolism and a contraindication to anticoagulation, who were treated with a bird's nest filter. METHODS:Retrospective review of case records and imaging department database at UCL Hospitals, London, UK. ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.76.5.395
更新日期:2000-10-01 00:00:00
abstract::In Asia Pacific, most countries have expanded HIV treatment guidelines to include all those with HIV infection and adopted antiretroviral treatment for prevention (TFP) as a blanket strategy for HIV control. Although the overall epidemic development associated with this focus is positive, the HIV epidemic in men who h...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2016-052669
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:To investigate the molecular epidemiology of isolates of Neisseria gonorrhoeae from Saskatchewan, Canada, using Neisseria gonorrhoeae multi antigen sequence typing (NG-MAST), and to assess associations between antimicrobial susceptibility (AMS) and specific strain types (STs). METHODS:320 consecutive gonoco...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2013-051229
更新日期:2014-06-01 00:00:00
abstract::Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. The causative organism, Calymmatobacterium granulomatis, has been cultured for the first time in many years and a polymerase chain reaction diagnostic using a colorimetric de...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.78.6.452
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Bacterial vaginosis (BV) is characterised by a change in the microbial composition of the vagina. The BV-associated organisms outnumber the health-associated Lactobacillus species and form a polymicrobial biofilm on the vaginal epithelium, possibly explaining the difficulties with antibiotic treatment. A bet...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052475
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:To inform control strategies undertaken as part of an outbreak of Shigella flexneri 3a among men who have sex with men (MSM). METHODS:All men aged ≥18 years diagnosed with S flexneri 3a between October 2012 and May 2013 were invited to participate. Semistructured in-depth quantitative interviews were conduc...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052014
更新日期:2015-12-01 00:00:00
abstract:STUDY DESIGN:This study investigated whether access to genitourinary medicine (GUM) clinics meets UK-recommended standards. METHODS:In January 2014 and 2015, postal questionnaires about appointment and service characteristics were sent to lead clinicians of UK GUM clinics. In February 2014 and 2015, researchers posing...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052882
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and clinical features of Trichomonas vaginalis (TV) infection in men. METHODS:Men attending a public STD clinic in Baltimore, Maryland, were evaluated between March and July 2000. Clinicians recorded a standardised history and clinical examination. Urethral swab specimens were col...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.2.151
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:To examine herpes simplex virus type 2 (HSV-2) incidence over four periods to age 38 in a birth cohort, and to compare risks for men and women, taking into account sexual behaviour. METHODS:At ages 21, 26, 32 and 38, participants in the Dunedin Multidisciplinary Health and Development Study were invited to ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2013-051235
更新日期:2014-05-01 00:00:00
abstract::This review will delineate performance characteristics and limitations, as far as they are known, of the new glycoprotein G based, type specific HSV serologies. Several of these tests have been FDA approved in the United States for use in adults. With the departure of Gull/Meridian from the HSV serology market, it is ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.77.4.232
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:Doxycycline, one of two recommended therapies for non-gonococcal urethritis (NGU), consists of a 7-day course of therapy (100 mg BID). Since suboptimal adherence may contribute to poor treatment outcomes, we examined the association between self-reported imperfect adherence to doxycycline and clinical and mic...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,随机对照试验
doi:10.1136/sextrans-2013-051174
更新日期:2014-02-01 00:00:00