Abstract:
:The aim of this independent study was to investigate differences in efficacy between HR, (0-[beta-hydroxyethyl]-rutosides) and D+H (500 mg, diosmin+hesperidin) in patients with chronic venous insufficiency (CVI). A first group of 90 patients with severe venous hypertension (CVI, ankle swelling) were randomized into an HR or a D+H group. The HR group received oral HR (2 g/day, 8 weeks); the D+H group received a 500 mg tablet 3 times daily for 8 weeks. A second group of comparable patients was included in a registry following the same study format. Patients were openly included; the 2 treatments were administered with the same methods and procedures. Clinical conditions were comparable to those described in the randomized study. Patients treated for at least 8 weeks were included in the registry. A number of physicians (specialists or general practitioners) included patients when they considered that clinical conditions were compatible with using 1 of the 2 treatments on the basis of their personal evaluation and experience. When cases were compatible with the registry, the prescribing physician communicated the case. Patients were evaluated without interfering with the treatment. Main targets of evaluation were skin flux at rest (RF), strain-gauge-derived rate of ankle swelling (RAS), and analogue symptoms score (ASLS). Ninety subjects completed the study in the first group; 122 in the second, registry group (total of 212 patients). The first and second (registry) groups and the 2 treatment groups were comparable for age and sex distribution. The pooled mean age was 42 years (SD +/-5.5) in the HR group (46+62 patients) and 41.5 (SD +/-6) in the D+H group (44+60 patients). Considering pooled data there were no differences in microcirculatory parameters between the pooled treatment groups at inclusion. A significant decrease (p<0.05) in RF and RAS was observed in the HR group at 8 weeks. The decrease in resting skin flux and in capillary filtration was associated with a significant improvement in signs/symptoms (analogue scale line) from an average of 9.4 (range 3-10) to 3.3 (4-6) (p<0.05). Significantly smaller variations were observed in the D+H group. The decrease in RF was 47.6% in the HR group vs 15.7% in the D+H group. The decrease in RAS was 40.9% in the HR group vs 12.8% in the D+H group. The decrease in ASLS was 64.8% in the HR group vs 12.9% in the comparative group. In conclusion venous microangiopathy and edema were improved by the treatment with HR both in the randomized study and in the pooled analysis. The comparison with D+H indicates that HR is comparatively more effective both on microcirculatory parameters and on signs/symptoms of CVI.
journal_name
Angiologyjournal_title
Angiologyauthors
Cesarone MR,Belcaro G,Pellegrini L,Ledda A,Di Renzo A,Vinciguerra G,Ricci A,Gizzi G,Ippolito E,Fano F,Dugall M,Acerbi G,Cacchio Mdoi
10.1177/000331970505600101subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1-8issue
1eissn
0003-3197issn
1940-1574journal_volume
56pub_type
临床试验,杂志文章,随机对照试验相关文献
ANGIOLOGY文献大全abstract::The purpose of this study was to determine whether daily physical activity was independently related to endogenous fibrinolysis in subjects with peripheral arterial disease (PAD). One hundred and six subjects with peripheral arterial disease (PAD) and intermittent claudication were characterized on the activity level ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970205300401
更新日期:2002-07-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) carries a poor prognosis. This study examined the non-invasive parameters that may be predictive of survival in two groups of patients, short-term survivors who died within one year of onset of symptoms (Group I, 6 patients) and long-term survivors who survived greater than one year of pre...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978403500804
更新日期:1984-08-01 00:00:00
abstract::Left atrial (LA) storage fraction is defined as the ratio of storage volume of the left atrium (LA) during ventricular systole to left ventricular (LV) stroke volume. To test their hypothesis that left atrial (LA) storage fraction is increased to compensate for impaired LV filling in the heart of aged subjects or with...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979404501108
更新日期:1994-11-01 00:00:00
abstract::Hemorrhoidal disease (HD) is a trophic disorder of the anal canal characterized by recurrent, self-resolving acute episodes. The author reports the results of a double-blind, placebo-controlled trial of the efficacy of Daflon 500 mg in the treatment of acute and chronic symptoms of hemorrhoids. One hundred and twenty ...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-06-01 00:00:00
abstract::"Micro" and "macro" peripheral embolisms during coronary angiography have been described. In all these cases, the aorta or the left heart chambers have been the source of embolus. A patient who during coronary angiography for acute inferior myocardial infarction experienced acute embolism of the left common femoral ar...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970105200709
更新日期:2001-07-01 00:00:00
abstract::Endothelial cell-specific molecule 1 ([ESM-1], endocan) is a new biomarker of endothelial dysfunction, which may be involved in the pathogenesis of atherosclerosis and stress hyperglycemia in patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we investigated serum ESM-1 levels in patien...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319715621996
更新日期:2016-10-01 00:00:00
abstract::The current study was designed to investigate the features of a family with familial hypercholesterolemia (FH). Twenty members of 3 generations in a family with hypercholesterolemia were enrolled in the study. The data collected were from clinical observation and subjected to pedigree analysis. The proband was a 41-ye...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970305400611
更新日期:2003-11-01 00:00:00
abstract::Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709337305
更新日期:2010-02-01 00:00:00
abstract::Safety and thrombus imaging capabilities of the 99mTc-labeled form of a new F(ab')2 monoclonal antibody (MoAb) against fragment D dimers from cross-linked human fibrin, previously shown to be effective labeled to 131I in detecting venous thrombi in the rabbit, were investigated. Sixteen patients (seven men, mean age: ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979905000203
更新日期:1999-02-01 00:00:00
abstract:INTRODUCTION:Computed tomography angiography (CTA) is the gold standard follow-up modality after endovascular aneurysm repair (EVAR). A potential alternative noninvasive and less expensive modality is duplex ultrasound scanning (DUS). METHODS:We studied 314 follow-up paired scans (DUS and CTA) in 59 patients with EVAR...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709348296
更新日期:2010-02-01 00:00:00
abstract::This report describes a case of aneurysm of the ascending aorta with secondary, severe, aortic valve incompetence following temporal arteritis in a sixty-five-year-old woman. ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978703800909
更新日期:1987-09-01 00:00:00
abstract::Peripheral arterial disease (PAD) is a condition with high mortality, but it is amenable to secondary prevention. Data on its prevalence in Thailand are scarce. To study the prevalence of PAD in a middle-class, urban Thai population, a cross-sectional study was conducted at the Electric Generating Authority of Thailan...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319707303652
更新日期:2007-10-01 00:00:00
abstract::Sixty patients suffering from arterial hypertension and/or obliterative arteriopathy of the lower limbs (20 hypertensive uncomplicated [H group], 20 normotensive affected by obliterative arteriopathy [A group], 20 suffering from both hypertension and peripheral arterial disease [HA group]) were studied, by strain gaug...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979704800307
更新日期:1997-03-01 00:00:00
abstract::Flunarizine in vivo protects against endothelial cell damage induced by intravenous injection of citrate, CaCl2, or lactate in rats. Its effect is optimal at the low oral dose of 0.1 mg/kg, corresponding to the clinically used one. It lasts for at least 8 hours. Edema formation, platelet activation, and venostatic thr...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978103200702
更新日期:1981-07-01 00:00:00
abstract::Beta blockers are one of the oral agents shown to decrease cardiovascular morbidity and mortality rates in randomized, controlled trials, and hence, they are widely used for the management of many cardiovascular situations. In terms of side effects there are 3 major modes of action: (1) contraction of smooth muscles, ...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/000331970205300617
更新日期:2002-11-01 00:00:00
abstract::Obesity and metabolic syndrome (MetS) are public health problems and are increasing globally. We assessed the differences in lipid profiles through lipid testing, thrombotic and inflammatory parameters, and oxidative stress indexes between overweight and obese patients with MetS in a Turkish adult population. We inclu...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319720970161
更新日期:2021-02-01 00:00:00
abstract::Arterial calcification in different arterial beds has been observed to be an independent predictor of mortality. The association of abdominal visceral artery calcium with all-cause mortality remains unexplored. Patients who had undergone contrast-enhanced computerized tomography (CT) imaging for routine assessment of ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319718796889
更新日期:2019-03-01 00:00:00
abstract::The angiographic appearance of arterio-venous shunting has been reported in one previous case of a patient with acute severe transplant rejection. Two additional cases are presented here. In the first the arteriovenous shunting is massive, and the venous filling is within the first second of the study. In the second t...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977802900106
更新日期:1978-01-01 00:00:00
abstract::The patient's position during laparoscopic surgery can have a clinically relevant effect on lower limb and splanchnic circulation; this factor has not yet been investigated with respect to oxidative stress markers. In order to assess this effect, a prospective clinical trial was designed wherein 2 groups of patients w...
journal_title:Angiology
pub_type: 临床试验,杂志文章
doi:10.1177/000331970505600414
更新日期:2005-07-01 00:00:00
abstract::The hypothesis that blood rheology is of prognostic value in patients with arteriosclerotic diseases was tested in a prospective study of 843 patients at a rehabilitation clinic. They were tested for blood serum and plasma viscosity, hematocrit, fibrinogen, red cell aggregation and deformability, erythrocyte sedimenta...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979104201204
更新日期:1991-12-01 00:00:00
abstract::This was a retrospective study that assessed achievement of lipid-lowering treatment targets in the setting of a University Hospital Lipid Clinic. Low-density lipoprotein cholesterol (LDL-C) goal attainment according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III) and European Societ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319714535073
更新日期:2015-04-01 00:00:00
abstract::Noninvasive tests have been developed to provide qualitative and quantitative information that can offer answers to most questions posed in venous diseases. While duplex scanning is used to assess the macrocirculation, microcirculatory methods assess and quantify venous microangiopathy. Laser Doppler flowmetry is used...
journal_title:Angiology
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract::The idea of cerebrovascular injury in cases of thromboangiitis obliterans was not strange to Leo Buerger, but Jäger (1932), as well Lindenberg and Spatz (1939), first established it. The aim of this study was to investigate the hemodynamics in the basal cerebral arteries by means of transcranial Doppler in patients wi...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979704800609
更新日期:1997-06-01 00:00:00
abstract::A 71-year-old man, a cigarette smoker with long-term asbestos exposure, developed multifocal malignant sarcomatous pleural mesothelioma that metastasized to the left ventricular endocardium without invading pericardium, myocardium, or the contiguous pulmonary vein. This is the first reported case of malignant pleural ...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/0003319706290737
更新日期:2006-08-01 00:00:00
abstract::Superficial venous thrombosis usually resolves spontaneously in a few weeks. In most cases, treatment includes peroral analgesics or nonsteroidal anti-inflammatory drugs accompanied by the recommendation to wear elastic stockings and perform regular mild ambulation. In contrast to this "standard treatment," a recent A...
journal_title:Angiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/0003319706297741
更新日期:2007-04-01 00:00:00
abstract::The correlations between lipid and lipoprotein measurements and other risk factors of coronary artery disease were evaluated in 101 men undergoing coronary angiography. Clinically significant disease was present in 75 patients, whereas 24 had no observable lesions and 2 had minimal lesions. Comparisons of individual l...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100704
更新日期:1990-07-01 00:00:00
abstract::The need to standardize treatment with high-dose IV standard heparin by using activated partial thromboplastin time (APTT) reagents tested for their heparin sensitivity and by establishing a standard treatment schedule led to the development of the "Lainz concept" of heparin management. The determination of heparin se...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979504600404
更新日期:1995-04-01 00:00:00
abstract::The feasibility, safety, and value of coronary computed tomographic angiography (CCTA) in evaluating orthotopic liver transplant (OLT) candidates are unknown. We studied a cohort of consecutive OLT candidates with intermediate-to-high risk of coronary artery disease (CAD). Intermediate risk candidates received CCTA, a...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319714563784
更新日期:2015-10-01 00:00:00
abstract::The authors encountered a forty-nine-year-old man with a lower limb ulcer refractory to intensive conservative therapy. No varicose vein was found anywhere, and the usual phlebographies and foot venous pressure measurement failed to diagnose it as a venous stasis ulcer. A direct phlebography method developed by the au...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979604701208
更新日期:1996-12-01 00:00:00
abstract::Although lipoprotein (a) [Lp(a)] has been shown to interfere with thrombolysis in vitro, its effects on thrombolytic therapy in patients with acute myocardial infarction (MI) are not clear. The authors evaluated 32 male patients ages thirty-five to seventy-five (mean fifty-two +/- ten) with the diagnosis of acute MI w...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979504600812
更新日期:1995-08-01 00:00:00