Protection by flunarizine against endothelial cell injury in vivo.

Abstract:

:Flunarizine in vivo protects against endothelial cell damage induced by intravenous injection of citrate, CaCl2, or lactate in rats. Its effect is optimal at the low oral dose of 0.1 mg/kg, corresponding to the clinically used one. It lasts for at least 8 hours. Edema formation, platelet activation, and venostatic thrombosis subsequent to endothelial cell injury consequently are also inhibited by flunarizine. The compound does not affect platelet function, plasma coagulation or generation of PGI2 by vascular tissue and does not impair normal haemostasis at effective doses. As for its vascular and hemorrheological effects, the protection by flunarizine against endothelial injury may be related to its Ca2+-antagonistic properties.

journal_name

Angiology

journal_title

Angiology

authors

Hladovec J,De Clerck F

doi

10.1177/000331978103200702

subject

Has Abstract

pub_date

1981-07-01 00:00:00

pages

448-62

issue

7

eissn

0003-3197

issn

1940-1574

journal_volume

32

pub_type

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