Abstract:
:Flunarizine in vivo protects against endothelial cell damage induced by intravenous injection of citrate, CaCl2, or lactate in rats. Its effect is optimal at the low oral dose of 0.1 mg/kg, corresponding to the clinically used one. It lasts for at least 8 hours. Edema formation, platelet activation, and venostatic thrombosis subsequent to endothelial cell injury consequently are also inhibited by flunarizine. The compound does not affect platelet function, plasma coagulation or generation of PGI2 by vascular tissue and does not impair normal haemostasis at effective doses. As for its vascular and hemorrheological effects, the protection by flunarizine against endothelial injury may be related to its Ca2+-antagonistic properties.
journal_name
Angiologyjournal_title
Angiologyauthors
Hladovec J,De Clerck Fdoi
10.1177/000331978103200702subject
Has Abstractpub_date
1981-07-01 00:00:00pages
448-62issue
7eissn
0003-3197issn
1940-1574journal_volume
32pub_type
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