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Clinical experiences using everolimus-eluting stents in patients with coronary artery disease.

Abstract：

:Despite the growing use of drug-eluting stents, restenosis remains to occur especially in high risk subgroups like patients with diffuse in-stent restenosis. This observation is supporting the search for new and potentially even more effective drug eluting stent systems. Everolimus has been used in conjunction with a new bioabsorbable polymer and gave promising results in initial clinical studies. In FUTURE I, a single-center, single-blinded randomized safety and feasibility study enrolling 15 patients with bare metal stents and 27 patients with everolimus-coated stents, 30-day MACE rate was 0% in both groups. In-stent late loss at six months was 0.83 mm in the control group and 0.10 mm in the everolimus group (p < 0.0001). In FUTURE II, a randomized multi-center study, a total of 64 patients were enrolled confirming safety and feasibility. After 6 months late loss was 0.85 mm in the control group and 0.12 mm in the everolimus group (p < 0.001).

journal_name

J Interv Cardiol

journal_title

Journal of interventional cardiology

authors

Störger H,Grube E,Hofmann M,Schwarz F,Haase J

doi

10.1111/j.1540-8183.2004.04080.x

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

387-90

issue

6

eissn

0896-4327

issn

1540-8183

pii

JOIC4080

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验

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