Nursing home outbreak of influenza A (H3N2): evaluation of vaccine efficacy and influenza case definitions.

Abstract:

OBJECTIVES:Describe an outbreak of influenza A (H3N2); provide an analysis of vaccine efficacy; measure the sensitivity, specificity, and positive predictive value of 3 clinical case definitions of influenza. SETTING:A nursing home in Washington County, Maryland. The outbreak involved 52 residents (attack rate = 47.7%) and at least 10 of 140 employees (minimum attack rate = 7.1%). RESULTS:Twenty-five residents exhibited a 4-fold or greater increase in titer to influenza A/Sichuan/2/87. Vaccine efficacy was measured at -7.1%, suggesting that the influenza vaccine in 1988/1989 did not offer optimal protection against influenza A infection for the institutionalized elderly. CONCLUSIONS:The outbreak was a clear indicator of the need for rapid diagnosis. With the use of rapid diagnostic tests, influenza A could have been detected in time to use amantadine.

authors

Taylor JL,Dwyer DM,Coffman T,Groves C,Patel J,Israel E

doi

10.1086/646479

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

93-7

issue

2

eissn

0899-823X

issn

1559-6834

journal_volume

13

pub_type

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