Helicobacter pylori-positive patients with pruritic skin diseases are at increased risk for gastric cancer.

abstract：BACKGROUND:Although lactulose and polyethylene glycol are osmotic laxatives widely used in the treatment of chronic constipation, no study has been conducted to compare their actions on the colonic bacterial ecosystem, which has an important influence on host health. AIM:To assess the effects of lactulose and polyethy...

journal_title：Alimentary pharmacology & therapeutics

authors： Bouhnik Y,Neut C,Raskine L,Michel C,Riottot M,Andrieux C,Guillemot F,Dyard F,Flourié B

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:The role of mesalazine in preventing the clinical recurrence of Crohn's disease after surgery has been shown in a meta-analysis of all published studies. No clear relationship, however, has been shown between dosage and response. AIM:To evaluate whether 4.0 g/day of mesalazine may offer therapeutic advantag...

journal_title：Alimentary pharmacology & therapeutics

authors： Caprilli R,Cottone M,Tonelli F,Sturniolo G,Castiglione F,Annese V,Papi C,Viscido A,Cammà C,Corrao G,Latella G

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Data on tenofovir alafenamide fumarate (TAF) for preventing mother-to-child transmission of hepatitis B virus (HBV) are lacking. AIMS:To investigate the efficacy and safety of TAF therapy for preventing hepatitis B mother-to-child transmission. METHODS:Mothers with chronic HBV infection, positive for hepat...

journal_title：Alimentary pharmacology & therapeutics

authors： Ding Y,Cao L,Zhu L,Huang Y,Lin C,Wang Y,Liu Y,Sheng Q,Wang S,Fan J,Chen R,Gan W,Chen B,Pan CQ

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Malnutrition and jaundice are independent prognostic factors in cirrhosis. AIM:To assess the impact of enteral nutrition on the survival of alcoholic cirrhotic patients with jaundice but without acute alcoholic hepatitis. METHODS:The study was a multicentre prospective randomised controlled trial comparing...

journal_title：Alimentary pharmacology & therapeutics

authors： Dupont B,Dao T,Joubert C,Dupont-Lucas C,Gloro R,Nguyen-Khac E,Beaujard E,Mathurin P,Vastel E,Musikas M,Ollivier I,Piquet MA

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Low-dose thiopurine-allopurinol (LDTA) combination therapy is a commonly applied optimisation strategy in IBD patients with a skewed thiopurine metabolism. AIM:To assess continued LDTA maintenance treatment at annual intervals and explore risk factors for treatment cessation METHODS: Adult IBD patients trea...

journal_title：Alimentary pharmacology & therapeutics

authors： Kreijne JE,de Veer RC,de Boer NK,Dijkstra G,West R,Moorsel SAW,de Jong DJ,van der Woude CJ,de Vries AC,of the Dutch Initiative on Crohn, Colitis (ICC).

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well recognised. However, most studies have focused on demonstrating that CDI is associated with adverse outcomes in IBD patients. Few have attempted to identify predictors of se...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Guzman-Perez R,Gainer V,Cai T,Churchill S,Kohane I,Plenge RM,Murphy S

更新日期：2012-04-01 00:00:00

abstract：:Physicians occasionally embark on a work-up that, after a lengthy path, leads them to a clinical situation similar to that from which they started their original pursuit. This article aims to describe the characteristics of circular medical management and means for its avoidance. The underlying medical problem often p...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Despite similar clinical symptoms, collagenous colitis (CC) and lymphocytic colitis (LC) are considered two distinct disease entities. AIM:To compare pathoanatomical findings, clinical presentations, risk factors, course of diseases and response to treatment in CC and LC to establish whether they could be s...

journal_title：Alimentary pharmacology & therapeutics

authors： Rasmussen MA,Munck LK

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The xenobiotic nuclear pregnane X receptor is implicated in many physiological pathways and diseases, including bile acid detoxification and cholestasis. Aim To estimate the contribution of common gene variants of the xenobiotic receptor (pregnane X receptor, PXR) to genetic susceptibility to intrahepatic ch...

journal_title：Alimentary pharmacology & therapeutics

authors： Castaño G,Burgueño A,Fernández Gianotti T,Pirola CJ,Sookoian S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Colitis is a significant complication of immune checkpoint inhibitors (ICI). Currently, clinical and endoscopic severity are used to guide therapy. AIMS:To investigate associations between clinical, endoscopic, and histological features with outcomes METHODS: We identified 149 patients from seven institutio...

journal_title：Alimentary pharmacology & therapeutics

authors： Pai RK,Pai RK,Brown I,Choi WT,Schaeffer DF,Farnell D,Kumarasinghe MP,Gunawardena D,Kim BH,Friedman M,Ghayouri M,Lauwers GY

更新日期：2021-01-01 00:00:00

abstract：:Studies from the Western hemisphere have established the efficacy and safety of tegaserod in women with irritable bowel syndrome and constipation. This review summarizes the results of recent studies from around the world that confirm the efficacy and safety of tegaserod, and expand our understanding of the role of th...

journal_title：Alimentary pharmacology & therapeutics

authors： Chey WD

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:The efficacy of cyclosporin in the management of ulcerative colitis is recognized. Not all patients respond to this treatment. Existing clinical and laboratory parameters are of little use in identifying those most likely to respond. AIMS:To determine whether in-vitro sensitivity to cyclosporin as measured ...

journal_title：Alimentary pharmacology & therapeutics

authors： McCormack G,O'Donoghue D,Baird A

更新日期：2001-05-01 00:00:00

abstract：:An analysis carried out in 1994 by the WHO International Agency for Research on Cancer (IARC) resulted in Helicobacter pylori being designated as a Group 1 carcinogen and thus clearly having an association with the development of gastric cancer. In the case of H. pylori, the evaluation was made solely on the basis of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Asaka M,Kudo M,Kato M,Sugiyama T,Takeda H

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Cardiac dysfunction is frequently observed in patients with cirrhosis. There remains a paucity of data from routine clinical practice regarding the role of echocardiography in the pre-assessment of transjugular intrahepatic portosystemic stent-shunt. AIM:Our study aimed to investigate if echocardiography pa...

journal_title：Alimentary pharmacology & therapeutics

authors： Armstrong MJ,Gohar F,Dhaliwal A,Nightingale P,Baker G,Greaves D,Mangat K,Zia Z,Karkhanis S,Olliff S,Mehrzad H,Steeds RP,Tripathi D

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Aim of this work was to improve standardization of the 13C-urea breath test (13C-UBT) by evaluating the effect of drug administration, feeding and colonic ureolysis on the UBT results. METHODS:Three different studies were performed. First, a 13C-UBT was performed in 41 Helicobacter pylori infected subjects ...

journal_title：Alimentary pharmacology & therapeutics

authors： Perri F,Maes B,Geypens B,Ghoos Y,Hiele M,Rutgeerts P

更新日期：1995-12-01 00:00:00

abstract：:Chemotherapy and radiotherapy, whilst highly effective in the treatment of neoplasia, can also cause damage to healthy tissue. In particular, the alimentary tract may be badly affected. Severe inflammation, lesioning and ulceration can occur. Patients may experience intense pain, nausea and gastro-enteritis. They are ...

journal_title：Alimentary pharmacology & therapeutics

authors： Duncan M,Grant G

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The most commonly used second-line Helicobacter pylori eradication regimens are bismuth-containing quadruple therapy and levofloxacin-containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens. AIMS:To evaluate the ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gisbert JP,Romano M,Gravina AG,Solís-Muñoz P,Bermejo F,Molina-Infante J,Castro-Fernández M,Ortuño J,Lucendo AJ,Herranz M,Modolell I,Del Castillo F,Gómez J,Barrio J,Velayos B,Gómez B,Domínguez JL,Miranda A,Martorano M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:One-week triple therapy consisting of omeprazole 20 mg b.d., clarithromycin 250 mg b.d. and tinidazole 500 mg b.d. is an effective therapy for H. pylori infection with a cure rate of 93%. We therefore compared two similar 1-week regimens consisting of a lansoprazole, clarithromycin and either metronidazole o...

journal_title：Alimentary pharmacology & therapeutics

authors： Jaup BH,Norrby A

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Few outcome studies directly compare Helicobacter pylori eradication therapy with maintenance H2-antagonist therapy in duodenal ulcer disease. AIM:To examine prospectively the efficacy of H. pylori eradication therapy with ranitidine maintenance therapy over 1 year in patients with confirmed chronic duodena...

journal_title：Alimentary pharmacology & therapeutics

authors： Prach AT,Malek M,Tavakoli M,Hopwood D,Senior BW,Murray FE

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Mild impairments of cognition or 'Brain fog' are often reported by patients with coeliac disease but the nature of these impairments has not been systematically investigated. AIM:This longitudinal pilot study investigated relationships between cognitive function and mucosal healing in people with newly diag...

journal_title：Alimentary pharmacology & therapeutics

authors： Lichtwark IT,Newnham ED,Robinson SR,Shepherd SJ,Hosking P,Gibson PR,Yelland GW

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The Th2 allergic pathway in eosinophilic oesophagitis (EoE) responds to food antigen exposure. AIM:To compare the presence and temporal pattern of food antigen penetration in oesophageal mucosa in active and inactive EoE and controls METHODS: Thirty-two patients with EoE (20 active) and 10 controls were ask...

journal_title：Alimentary pharmacology & therapeutics

authors： Ravi A,Marietta EV,Alexander JA,Peterson K,Lavey C,Geno DM,Murray JA,Katzka DA

更新日期：2021-02-01 00:00:00

abstract：:The purpose of this study was to determine whether portal hypertension potentiates intestinal ulceration induced by indomethacin. Portal hypertension was produced in male Sprague-Dawley rats by two-staged ligation of the portal vein. Sham-operated rats were used as controls. The rats were given 20 mg/kg of indomethaci...

journal_title：Alimentary pharmacology & therapeutics

authors： Jonas GM,Erickson RA,Chung K

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:There is a need for a simple, therapeutic test that is of diagnostic value and can also provide rapid symptom relief in patients who present with classic, mild symptoms suggestive of gastro-oesophageal reflux disease (GERD), when the diagnosis is based on symptom assessment alone. AIM:To assess the diagnost...

journal_title：Alimentary pharmacology & therapeutics

authors： Bate CM,Riley SA,Chapman RW,Durnin AT,Taylor MD

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Adverse events leading to discontinuation or dose reduction of thiopurine therapy occur in 9-28% of patients with inflammatory bowel disease. AIMS:To evaluate the influence of thiopurine methyltransferase status and thiopurine metabolites in a large patient population for the risk of developing adverse even...

journal_title：Alimentary pharmacology & therapeutics

authors： Hindorf U,Lindqvist M,Hildebrand H,Fagerberg U,Almer S

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Colorectal cancer is the second commonest cause of cancer mortality. Some countries are implementing colorectal cancer screening to detect lesions at an early stage using non-invasive tools like the faecal immunochemical test. Despite affordability, this test shows a low sensitivity for precancerous lesions ...

journal_title：Alimentary pharmacology & therapeutics

authors： Malagón M,Ramió-Pujol S,Serrano M,Serra-Pagès M,Amoedo J,Oliver L,Bahí A,Mas-de-Xaxars T,Torrealba L,Gilabert P,Miquel-Cusachs JO,García-Nimo L,Saló J,Guardiola J,Piñol V,Cubiella J,Castells A,Aldeguer X,Garcia-Gil J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Drug toxicity is the leading cause of acute liver failure in the United States. Further understanding of hepatotoxicity is becoming increasingly important as more drugs come to market. AIMS:(i) To provide an update on recent advances in our understanding of hepatotoxicity of select commonly used drug classe...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang CY,Schiano TD

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:Although little mortality is associated with irritable bowel syndrome, curative therapy does not exist and thus the economic impact of this disorder may be considerable. METHODS:A systematic review of the literature was performed. Studies were included if their focus was irritable bowel syndrome, and direct...

journal_title：Alimentary pharmacology & therapeutics

authors： Inadomi JM,Fennerty MB,Bjorkman D

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Both high-fibre dietary advice and the prescription of fibre as a bulking agent are very common in primary and secondary care management of irritable bowel syndrome. Irritable bowel syndrome patients with constipation may have delayed intestinal transit. Therefore, fibres that accelerate intestinal transit m...

journal_title：Alimentary pharmacology & therapeutics

authors： Bijkerk CJ,Muris JW,Knottnerus JA,Hoes AW,de Wit NJ

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Small bowel bacterial overgrowth is common in Crohn's disease but its treatment is not clearly defined. Metronidazole and ciprofloxacin are effective antibiotics in active Crohn's disease. AIM:To investigate the efficacy of metronidazole and ciprofloxacin in the treatment of bacterial overgrowth in patients...

journal_title：Alimentary pharmacology & therapeutics

authors： Castiglione F,Rispo A,Di Girolamo E,Cozzolino A,Manguso F,Grassia R,Mazzacca G

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors effectively suppress intragastric acid. Nocturnal acid breakthrough occurs on any dosing regimen of oral proton pump inhibitors. Histamine(2)-receptor antagonists (H(2)RA) suppress intragastric acidity independently of meals and help to control nocturnal acid breakthrough. Because prot...

journal_title：Alimentary pharmacology & therapeutics

authors： Tutuian R,Katz PO,Ahmed F,Korn S,Castell DO

更新日期：2002-03-01 00:00:00