Abstract：
OBJECTIVE:To investigate which cognitive and affective features contribute most to responder/non-responder group separation during a switching trial with atypical antipsychotic. DESIGN:A prospective open trial with an atypical antipsychotic (olanzapine). PATIENTS:One hundred and thirty-four patients meeting diagnostic criteria for schizophrenia, schizophreniform or schizoaffective disorder began an 8-week open-label olanzapine treatment at a dose of 5 mg/day which was increased to 10 mg/day after one week. INTERVENTIONS:Olanzapine during 8 weeks. Patients were considered as responders if their BPRS score decreased of at least 20% (n = 96) and non-responders if it did not (n = 38). Neuropsychological assessments were carried out at baseline, at four and at eight weeks. RESULTS:Neurocognitive measures were analyzed for discriminate factors between responder and non-responder groups. A regression analysis was applied to explain the effects of depression on each cognitive variable. Depression was found to be a weak discriminant factor, however this finding could not firmly establish that depression is a potential factor in explaining deficits and improvements in cognition.
journal_name
Brain Cognjournal_title
Brain and cognitionauthors
Stip E,Mancini-Marïe Adoi
10.1016/j.bandc.2004.02.066subject
Has Abstractpub_date
2004-08-01 00:00:00pages
463-5issue
3eissn
0278-2626issn
1090-2147pii
S0278262604000867journal_volume
55pub_type
临床试验,杂志文章abstract：:Identifying the information processing constraints that determine whether or not imagery moderates visual field asymmetries is essential for constructing a dynamic model of hemispheric interaction during language processing. In this investigation, we manipulated the global experimental context in which imageable and n...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:To compare mental rotation and mental size transformation, 128-channel EEG was recorded while subjects performed both tasks using random two-dimensional shapes as stimuli. Behavioural results showed significant linear effects of both size transformation and mental rotation on reaction times. Rotation ERPs showed exper...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/s0278-2626(03)00077-0
更新日期：2003-07-01 00:00:00
abstract：:Interference between concurrent tasks was used to investigate the brain basis of capacity limitations apparent when children encode information. Seventy-three right-handed children in Grades 1-4 engaged in speeded unilateral finger tapping while encoding a variable number of faces or numbers for subsequent recognition...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(87)90044-3
更新日期：1987-01-01 00:00:00
abstract：:This study was designed to investigate whether the neuropsychological correlates of the symptom dimensions of schizophrenia vary with the clinical state in patients followed from the acute to stable the phase of the illness. Fifteen patients were assessed for symptoms (SAPS-SANS) and undergone a complete neuropsycholo...
journal_title：Brain and cognition
pub_type： 临床试验,杂志文章
doi：10.1016/j.bandc.2004.08.027
更新日期：2005-02-01 00:00:00
abstract：:An individual's nervous and cognitive systems are lateralized, and handedness represents a behavioral manifestation of such organization. Therefore, accurately and reliably measuring handedness has repercussion on our understanding of both the human brain and cognition. The Edinburgh Handedness Inventory (EHI) is the ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2019.103618
更新日期：2019-12-01 00:00:00
abstract：:To help resolve the issue of whether developmental dyslexia (DD) is related to central auditory processing deficits or to language-specific processing deficits, we had nine dyslectic and nine nondyslectic right-handed undergraduate students perform linguistic (Experiment 1: phoneme identification) and nonlinguistic (E...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Performance deterioration over time, or time-on-task (TOT) effects, can be observed across a variety of tasks, but little attention has been paid to how TOT-related brain activity may differ based on task pacing and cognitive demands. Here, we employ a set of three closely related tasks to investigate the effect of th...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2019.103629
更新日期：2019-12-01 00:00:00
abstract：:A 53-year-old right-handed woman had an extensive lesion in the left hemisphere due to an infarction caused by vasospasm secondary to subarachnoid bleeding. She exhibited persistent expressive-vocal amusia with no symptoms of aphasia. Evaluation of the patient's musical competence using the Montreal Battery for Evalua...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2016.01.003
更新日期：2016-03-01 00:00:00
abstract：:Recently, the relationship between music and nonmusical cognitive abilities has been highly debated. It has been documented that formal music training would improve verbal, mathematical or visuospatial performance in children. In the experiments described here, we tested if visual perception and imagery abilities were...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/S0278-2626(03)00264-1
更新日期：2004-03-01 00:00:00
abstract：:How does the brain cause positive affective reactions to sensory pleasure? An answer to pleasure causation requires knowing not only which brain systems are activated by pleasant stimuli, but also which systems actually cause their positive affective properties. This paper focuses on brain causation of behavioral posi...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1016/s0278-2626(03)00014-9
更新日期：2003-06-01 00:00:00
abstract：:There is considerable variability among epilepsy centers in the methods and interpretations of the intracarotid amobarbital procedure. Prominent among these differences is the determination of language representation and assessment of language functions. Some centers rely on speech arrest following amobarbital injecti...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1997.0889
更新日期：1997-03-01 00:00:00
abstract：:Whereas right parietal damage can result in left hemineglect, the general population shows a subtle neglect of the right hemispace-known as pseudoneglect. A recent study has demonstrated that people collide to the right more often and attributed this bias to pseudoneglect. [Nicholls, M. E. R., Loftus, A., Meyer, K., &...
journal_title：Brain and cognition
pub_type： 临床试验,杂志文章
doi：10.1016/j.bandc.2008.04.003
更新日期：2008-11-01 00:00:00
abstract：:We hypothesized that facial attractiveness represents a dual judgment, a combination of reward-based, sexual processes, and aesthetic, cognitive processes. Herein we describe a study that demonstrates that sexual and nonsexual processes both contribute to attractiveness judgments and that these processes can be dissoc...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2009.10.002
更新日期：2010-03-01 00:00:00
abstract：:The orbitofrontal cortex contains the secondary taste cortex, in which the reward value of taste is represented. It also contains the secondary and tertiary olfactory cortical areas, in which information about the identity and also about the reward value of odours is represented. The orbitofrontal cortex also receives...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1016/S0278-2626(03)00277-X
更新日期：2004-06-01 00:00:00
abstract：:Symmetry is an important concept in biology, being related to mate selection strategies, health, and survival of species. In human faces, the relevance of left-right symmetry to attractiveness and health is not well understood. We compared the appearance of facial attractiveness, health, and symmetry in three separate...
journal_title：Brain and cognition
pub_type： 临床试验,杂志文章
doi：10.1016/j.bandc.2004.08.056
更新日期：2005-04-01 00:00:00
abstract：:Previous research has demonstrated that the language of older adults leads to denser representations in a high dimensional model of memory than does the language of younger adults (Conley & Burgess, in press), and thus that density in the model (HAL or the hyperspace analogue to language) may constitute a useful metri...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/s0278-2626(01)80040-3
更新日期：2001-06-01 00:00:00
abstract：:The Stroop color-naming task is one of the most widely studied tasks involving the inhibition of a prepotent response, regarded as an executive function. Several studies have examined performance on versions of the Stroop task under conditions of acute sleep deprivation. Though these studies revealed effects on Stroop...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2011.03.005
更新日期：2011-06-01 00:00:00
abstract：:Normal observers demonstrate a bias to process the left sides of faces during perceptual judgments about identity or emotion. This effect suggests a right cerebral hemisphere processing bias. To test the role of the right hemisphere and the involvement of configural processing underlying this effect, young and older c...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2007.07.001
更新日期：2008-03-01 00:00:00
abstract：:Studies on the effects of acute bouts of cardiovascular exercise on cognitive performances show contradictory findings due to methodological differences (e.g., exercise intensity, cognitive function assessed, participants' aerobic fitness level, etc.). The present study assessed the acute effect of exercise intensity ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2012.10.001
更新日期：2013-02-01 00:00:00
abstract：:Item recognition memory judgment can be based on two processes: item familiarity and/or the conscious recollection of the initial event. On the other hand, associative recognition relies preferably on conscious recollection. Since evidence points to a specific deficit of conscious recollection in schizophrenia, these ...
journal_title：Brain and cognition
pub_type： 杂志文章,meta分析
doi：10.1016/s0278-2626(03)00092-7
更新日期：2003-11-01 00:00:00
abstract：:Schizophrenia is characterized by heterogeneous brain abnormalities involving cerebral regions implied in the executive functioning. The dysexecutive syndrome is one of the most prominent and functionally cognitive features of schizophrenia. Nevertheless, it is not clear to what extend executive deficits are heterogen...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2012.01.008
更新日期：2012-06-01 00:00:00
abstract：:This study extends Duff and Hampson's [Duff, S., & Hampson, E. (2001). A sex difference on a novel spatial working memory task in humans. Brain and Cognition,47, 470-493] finding of a sex-related difference in favor of females for an object location memory task. Twenty female and 20 male undergraduate students perform...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2008.06.006
更新日期：2009-02-01 00:00:00
abstract：:Some attempts to explain category-specific disorders have stressed how different modality knowledge bases (i.e., visual knowledge vs motoric/functional knowledge) may underlie the distinction between living and nonliving things. This study examined 60 normal subjects for the relationship between picture naming in four...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Lateral eye movements (LEM) were measured for 32 right-handed subjects while responding to questions rated for verbal and visual-spatial cognitive content and for varying levels of emotionally stimulating content. The results indicated that eye movements were distributed to the right and left in response to verbal and...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(82)90022-7
更新日期：1982-10-01 00:00:00
abstract：:Thirteen nondemented patients with Parkinson's disease (PD) were compared with age-matched controls on two standard tests of implicit learning. A verbal version of the Serial Reaction Time (SRT) task was used to assess sequence learning and an artificial grammar (AG) task assessed perceptual learning. It was predicted...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.2001.1286
更新日期：2001-04-01 00:00:00
abstract：:Several studies have reported shifts in perceptual asymmetry during the menstrual cycle, but the potential confounding effect of mood changes has been largely ignored. In this study, 24 female subjects completed four visual laterality tasks and a mood questionnaire at three phases of the cycle. Results indicate no ove...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1997.0936
更新日期：1997-11-01 00:00:00
abstract：:Investigations using in vivo magnetic resonance (MR) morphometry have shown that left-right asymmetry of the planum temporale (PT) is a structural correlate of hemispheric functional asymmetries in adult humans (e.g., handedness, language representation). Postmortem studies of brains of fetuses and newborns have demon...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1006/brcg.1998.1072
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:Progressive myelination during adolescence implicates an increased vulnerability to neurotoxic substances and enduring neurocognitive consequences. This study examined the cognitive manifestations of altered white matter microstructure in chronic marijuana and alcohol-using (MJ+ALC) adolescents. METHODS:Thi...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2009.10.012
更新日期：2010-04-01 00:00:00
abstract：:Mind transforms the continuance of physical space-time into moments (the absolute Now) and blends these moments into an apparent continuity through an overlapping of unfolding capsules. The flow of psychological time is an illusion based on the rapid replacement of these capsules. Each mind computes the measure of tim...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(90)90026-k
更新日期：1990-11-01 00:00:00
abstract：:The present study investigates the event related potential (ERP) components associated with the random version of the Sustained Attention to Response Task (SART). The random SART is a Go/No-Go task in which the No-Go target appears unpredictably and rarely. In the present experiment, the EEG was recorded from 58 elect...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2007.05.005
更新日期：2008-02-01 00:00:00
