当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial.

Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial.

Abstract：

:We report a transfusion trial of platelets photochemically treated for pathogen inactivation using the synthetic psoralen amotosalen HCl. Patients with thrombocytopenia were randomly assigned to receive either photochemically treated (PCT) or conventional (control) platelets for up to 28 days. The primary end point was the proportion of patients with World Health Organization (WHO) grade 2 bleeding during the period of platelet support. A total of 645 patients (318 PCT and 327 control) were evaluated. The primary end point, the incidence of grade 2 bleeding (58.5% PCT versus 57.5% control), and the secondary end point, the incidence of grade 3 or 4 bleeding (4.1% PCT versus 6.1% control), were equivalent between the 2 groups (P =.001 by noninferiority). The mean 1-hour posttransfusion platelet corrected count increment (CCI) (11.1 x 10(3) PCT versus 16.0 x 10(3) control), average number of days to next platelet transfusion (1.9 PCT versus 2.4 control), and number of platelet transfusions (8.4 PCT versus 6.2 control) were different (P <.001). Transfusion reactions were fewer following PCT platelets (3.0% PCT versus 4.4% control; P =.02). The incidence of grade 2 bleeding was equivalent for PCT and conventional platelets, although posttransfusion platelet count increments and days to next transfusion were decreased for PCT compared with conventional platelets.

journal_name

Blood

journal_title

Blood

authors

McCullough J,Vesole DH,Benjamin RJ,Slichter SJ,Pineda A,Snyder E,Stadtmauer EA,Lopez-Plaza I,Coutre S,Strauss RG,Goodnough LT,Fridey JL,Raife T,Cable R,Murphy S,Howard F 4th,Davis K,Lin JS,Metzel P,Corash L,Koutso

doi

10.1182/blood-2003-12-4443

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

1534-41

issue

5

eissn

0006-4971

issn

1528-0020

pii

2003-12-4443

journal_volume

104

pub_type

临床试验,杂志文章,随机对照试验

相关文献

BLOOD文献大全
  • Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia.

    abstract：:Alteration of lineage-specific transcriptional programs for hematopoiesis causes differentiation block and promotes leukemia development. Here, we show that AML1/ETO, the most common translocation fusion product in acute myeloid leukemia (AML), counteracts the activity of retinoic acid (RA), a transcriptional regulato...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-09-045781

    authors： Fazi F,Zardo G,Gelmetti V,Travaglini L,Ciolfi A,Di Croce L,Rosa A,Bozzoni I,Grignani F,Lo-Coco F,Pelicci PG,Nervi C

    更新日期：2007-05-15 00:00:00

  • Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge.

    abstract：:Pharmacologic infusion of activated protein C (APC) improves survival in severe sepsis, and platelet factor 4 (PF4) accelerates APC generation in a primate thrombin-infusion model. We now tested whether endogenous platelet PF4 content affects APC generation. Mice completely deficient in PF4 (mPF4(-/-)) had impaired AP...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-03-081901

    authors： Kowalska MA,Mahmud SA,Lambert MP,Poncz M,Slungaard A

    更新日期：2007-09-15 00:00:00

  • New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls.

    abstract：:Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant so...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-12-4884

    authors： Hao Z,Guo C,Jiang X,Krueger S,Pietri T,Dufour S,Cone RE,O'Rourke J

    更新日期：2006-07-01 00:00:00

  • Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS.

    abstract：:Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Archibald DW,Zon L,Groopman JE,McLane MF,Essex M

    更新日期：1986-03-01 00:00:00

  • Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells.

    abstract：:HLA-G is a major histocompatibility complex class Ib molecule whose constitutive tissue distribution is restricted mainly to trophoblast cells at the maternal-fetal interface during pregnancy. In this study, we demonstrated the ability of the soluble HLA-G1 (sHLA-G1) isoform to inhibit fibroblast growth factor-2 (FGF2...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-12-019919

    authors： Fons P,Chabot S,Cartwright JE,Lenfant F,L'Faqihi F,Giustiniani J,Herault JP,Gueguen G,Bono F,Savi P,Aguerre-Girr M,Fournel S,Malecaze F,Bensussan A,Plouët J,Le Bouteiller P

    更新日期：2006-10-15 00:00:00

  • Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations.

    abstract：:Pharmaceutical preparations of normal human immunoglobulin (IgG) are known to contain high-avidity and neutralizing antibodies (Ab) to the cytokines interleukin (IL)-1alpha, IL-6, and interferon (IFN)alpha. To test for other cytokine Ab, 23 batches of IgG were tested for saturable binding to eight 125I-labeled recombi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Svenson M,Hansen MB,Ross C,Diamant M,Rieneck K,Nielsen H,Bendtzen K

    更新日期：1998-03-15 00:00:00

  • Reproductive capacity in iron overloaded women with thalassemia major.

    abstract：:The pathophysiology of iron-induced compromised fertility in women with thalassemia major (TM) was evaluated in 26 adult TM females. Low gonadotropin secretion resulted in reduced ovarian antral follicle count and ovarian volume, but levels of anti-müllerian hormone (AMH), a sensitive marker for ovarian reserve indepe...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-06-360271

    authors： Singer ST,Vichinsky EP,Gildengorin G,van Disseldorp J,Rosen M,Cedars MI

    更新日期：2011-09-08 00:00:00

  • alpha-thalassemia resulting from a negative chromosomal position effect.

    abstract：:To date, all of the chromosomal deletions that cause alpha-thalassemia remove the structural alpha genes and/or their regulatory element (HS -40). A unique deletion occurs in a single family that juxtaposes a region that normally lies approximately 18-kilobase downstream of the human alpha cluster, next to a structura...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Barbour VM,Tufarelli C,Sharpe JA,Smith ZE,Ayyub H,Heinlein CA,Sloane-Stanley J,Indrak K,Wood WG,Higgs DR

    更新日期：2000-08-01 00:00:00

  • Ligation of CD31 (PECAM-1) on endothelial cells increases adhesive function of alphavbeta3 integrin and enhances beta1 integrin-mediated adhesion of eosinophils to endothelial cells.

    abstract：:We determined the role of the heterophilic interaction of alphavbeta3 integrin on endothelial cells with CD31 on leukocytes in mediating leukocyte-endothelial cell interactions. Preincubation of interleukin-4 (IL-4)-stimulated human umbilical vein endothelial cells (HUVECs) with anti-CD31 monoclonal antibodies (MoAbs)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Chiba R,Nakagawa N,Kurasawa K,Tanaka Y,Saito Y,Iwamoto I

    更新日期：1999-08-15 00:00:00

  • Identification and characterization of epitopes of the receptor for hyaluronic acid-mediated motility (RHAMM/CD168) recognized by CD8+ T cells of HLA-A2-positive patients with acute myeloid leukemia.

    abstract：:The receptor for hyaluronic acid-mediated motility (RHAMM/CD168) has been described as a leukemia-associated antigen. To define T-cell epitopes of RHAMM/CD168 toward specific immunotherapies for acute myeloid leukemia (AML), 10 potential HLA-A2-binding RHAMM/CD168 peptides (R1 to R10) were synthesized based on compute...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-12-4787

    authors： Greiner J,Li L,Ringhoffer M,Barth TF,Giannopoulos K,Guillaume P,Ritter G,Wiesneth M,Döhner H,Schmitt M

    更新日期：2005-08-01 00:00:00

  • Origin of anti-idiotypic activity against anti-factor VIII autoantibodies in pools of normal human immunoglobulin G (IVIg).

    abstract：:Therapeutic preparations of polyspecific IgG obtained from plasma pools of a large number of normal donors (IVIg) express anti-idiotypic activity against a wide spectrum of natural and disease-associated autoantibodies. The present study investigated the origin of anti-idiotypic activity against autoantibodies to fact...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Dietrich G,Algiman M,Sultan Y,Nydegger UE,Kazatchkine MD

    更新日期：1992-06-01 00:00:00

  • MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.

    abstract：:MicroRNAs (miRNAs) have emerged as important regulators of the immune system. However, despite this prominence, our understanding of the function of miRNAs in the early hematopoietic stages is incomplete. In this study, we found that miR-139-5p negatively regulated the proliferation of hematopoietic stem cells and pro...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2016-02-702464

    authors： Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH

    更新日期：2016-10-27 00:00:00

  • Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML Working Party.

    abstract：:The median age of chronic myeloid leukemia (CML) patients is ~60 years, and age is still considered an important prognostic factor, included in Sokal and EURO risk scores. However, few data are available about the long-term outcome of older patients treated with imatinib (IM) frontline. We analyzed the relationship be...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-12-324228

    authors： Gugliotta G,Castagnetti F,Palandri F,Breccia M,Intermesoli T,Capucci A,Martino B,Pregno P,Rupoli S,Ferrero D,Gherlinzoni F,Montefusco E,Bocchia M,Tiribelli M,Pierri I,Grifoni F,Marzocchi G,Amabile M,Testoni N,Martin

    更新日期：2011-05-26 00:00:00

  • Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report.

    abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disease caused by mutations in the WAS gene, leading to thrombocytopenia, eczema, recurrent infections, autoimmune disease, and malignancy. Hematopoietic cell transplantation (HCT) is the primary curative approach, with the goal of correcting the underlying immunodeficienc...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019002939

    authors： Burroughs LM,Petrovic A,Brazauskas R,Liu X,Griffith LM,Ochs HD,Bleesing JJ,Edwards S,Dvorak CC,Chaudhury S,Prockop SE,Quinones R,Goldman FD,Quigg TC,Chandrakasan S,Smith AR,Parikh S,Dávila Saldaña BJ,Thakar MS,Phela

    更新日期：2020-06-04 00:00:00

  • Peripheral acute leukemia: high peripheral but low-marrow blast count.

    abstract：:We report five patients who had greater than 30% peripheral blasts and less than 30% marrow blasts. By the current standards these cases would be classified as myelodysplastic syndrome. Four of five patients progressed to acute leukemia within approximately 1 1/2 months of developing greater than 30% peripheral blasts...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Cason JD,Trujillo JM,Estey EH,Huh YO,Freireich EJ,Stass SA

    更新日期：1989-10-01 00:00:00

  • Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications.

    abstract：:Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, is an antioxidant with chemopreventive and chemotherapeutic actions. Based on its ability to modulate growth factor-mediated cell proliferation, we evaluated its efficacy in multiple myeloma (MM). EGCG induced both dose- and time-dependent growt...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-05-022814

    authors： Shammas MA,Neri P,Koley H,Batchu RB,Bertheau RC,Munshi V,Prabhala R,Fulciniti M,Tai YT,Treon SP,Goyal RK,Anderson KC,Munshi NC

    更新日期：2006-10-15 00:00:00

  • An animal model of allogeneic donor platelet refractoriness: the effect of the time of leukodepletion.

    abstract：:Approximately 50% of multi-transfused individuals become refractory to random donor platelets. Recent clinical data suggest that those patients receiving leukocyte-depleted blood products are less likely to become refractory to random donor platelets than recipients of non-leukocyte-depleted products. Leukocyte deplet...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Blajchman MA,Bardossy L,Carmen RA,Goldman M,Heddle NM,Singal DP

    更新日期：1992-03-01 00:00:00

  • Congenital dyserythropoietic anemias.

    abstract：:Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of inherited anemias that affect the normal differentiation-proliferation pathways of the erythroid lineage. They belong to the wide group of ineffective erythropoiesis conditions that mainly result in monolinear cytopenia. CDAs are classified into ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019000948

    authors： Iolascon A,Andolfo I,Russo R

    更新日期：2020-09-10 00:00:00

  • Critical roles for Rac GTPases in T-cell migration to and within lymph nodes.

    abstract：:Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an encounter between a T cell and its cognate antigen. This recirculation depends on signals from chemokine receptors, integrins, and the sphingosine-1-phosphate recepto...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-08-299438

    authors： Faroudi M,Hons M,Zachacz A,Dumont C,Lyck R,Stein JV,Tybulewicz VL

    更新日期：2010-12-16 00:00:00

  • Molecular and cellular effects of antisickling concentrations of alkylureas.

    abstract：:Alkylureas are capable of inhibiting sickling in vitro and the gelation of solutions of hemoglobin S at concentrations between 0.05 and 0.1 M with increasing effectiveness that is directly proportional to the length of the alkyl chain (butyl greater than propyl greater than ethyl greater than methyl). 6The inhibitory ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Elbaum D,Roth EF Jr,Neumann G,Jaffé ER,Bookchin RM,Nagel RL

    更新日期：1976-08-01 00:00:00

  • Correlation of minor histocompatibility antigen-specific cytotoxic T lymphocytes with graft-versus-host disease status and analyses of tissue distribution of their target antigens.

    abstract：:Peripheral blood mononuclear cells (PBMC) from 17 patients receiving HLA-identical sibling bone marrow grafts were stimulated with host pretransplant PBMC. Cytotoxic T-cell lines (TCL) with specificity for host pretransplant PBMC were obtained from 9 of these patients, all presenting with severe graft-versus-host dise...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Niederwieser D,Grassegger A,Auböck J,Herold M,Nachbaur D,Rosenmayr A,Gächter A,Nussbaumer W,Gaggl S,Ritter M

    更新日期：1993-04-15 00:00:00

  • Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia.

    abstract：:The synthetic cytokine (Synthokine) SC-55494 is a high-affinity interleukin-3 (IL-3) receptor ligand that stimulates greater in vitro multilineage hematopoietic activity than native IL-3, while inducing no significant increase in inflammatory activity relative to native IL-3. The aim of this study was to investigate t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Farese AM,Herodin F,McKearn JP,Baum C,Burton E,MacVittie TJ

    更新日期：1996-01-15 00:00:00

  • The molecular species composition of phosphatidylcholine affects cellular properties in normal and sickle erythrocytes.

    abstract：:The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes. Changes in molecular species composition of PC altered morphology as well as cellular defo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Kuypers FA,Chiu D,Mohandas N,Roelofsen B,Op den Kamp JA,Lubin B

    更新日期：1987-10-01 00:00:00

  • LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule.

    abstract：:LIRs are immunoglobulinlike receptors that have activating and inhibitory functions in leukocytes. Here we report the identification of the first LIR family member, LIR9, expressed as a membrane-bound receptor and as a secreted molecule. We identified 4 different forms of LIR9, 2 of which encode transmembrane molecule...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-05-1432

    authors： Borges L,Kubin M,Kuhlman T

    更新日期：2003-02-15 00:00:00

  • Familial and congenital polycythemia in three unrelated families.

    abstract：:Three families with polycythemia inherited through apparently different modes are described. Secondary causes of polycythemia were ruled out. Erythropoietin (EPO) levels were normal or low, even after phlebotomy. In vitro erythroid colony growth in standard assay cultures containing EPO was normal; however, in the abs...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Emanuel PD,Eaves CJ,Broudy VC,Papayannopoulou T,Moore MR,D'Andrea AD,Prchal JF,Eaves AC,Prchal JT

    更新日期：1992-06-01 00:00:00

  • Antibody-dependent cytolysis of the human leukemia cell line K-562 in the absence of effector cells or complement.

    abstract：:K-562 human leukemia cells grown in the presence of specific goat anti-K-562 gamma globulin, F(ab)'2, Fab', or Fab showed a decrease in DNA and protein syntheses and a loss of cell viability within several hours. Eventually all cells died and lysed within 2-5 days. These events occurred in the absence of added effecto...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Wust CJ,Green M,Lozzio CB,Lozzio BB

    更新日期：1982-01-01 00:00:00

  • Identification and expression of a common missense mutation (L302P) in the acid sphingomyelinase gene of Ashkenazi Jewish type A Niemann-Pick disease patients.

    abstract：:Types A and B Niemann-Pick disease (NPD) result from the deficient activity of acid sphingomyelinase (ASM; E.C. 3.1.4.12) and the resultant lysosomal accumulation of sphingomyelin. Type A disease is a fatal, neurodegenerative disorder of infancy, whereas type B disease has no neurologic manifestations and is character...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Levran O,Desnick RJ,Schuchman EH

    更新日期：1992-10-15 00:00:00

  • Biochemical markers of bone turnover following high-dose chemotherapy and autografting in multiple myeloma.

    abstract：:The effect of high-dose chemotherapy and autografting on bone turnover in myeloma is not known. A study of 32 myeloma patients undergoing blood or marrow transplant (BMT), conditioned with high-dose melphalan, was done. Bone resorption was assessed by urinary free pyridinoline (fPyr) and deoxypyridinoline (fDPyr), exp...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Clark RE,Flory AJ,Ion EM,Woodcock BE,Durham BH,Fraser WD

    更新日期：2000-10-15 00:00:00

  • Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

    abstract：:We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype and mutations occurring at the exon-12 of the NPM gene. In this paper, we have elu...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-11-4745

    authors： Falini B,Bolli N,Shan J,Martelli MP,Liso A,Pucciarini A,Bigerna B,Pasqualucci L,Mannucci R,Rosati R,Gorello P,Diverio D,Roti G,Tiacci E,Cazzaniga G,Biondi A,Schnittger S,Haferlach T,Hiddemann W,Martelli MF,Gu W,

    更新日期：2006-06-01 00:00:00

  • T-cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings: advantage of T-cell antibodies with narrow specificities.

    abstract：:T-cell depletion of donor marrow decreases graft-versus-host disease resulting from transplants from unrelated and human leukocyte antigen (HLA)-mismatched related donors. However, there are diverse strategies for T-cell-depleted transplantation, and it is uncertain whether any improve leukemia-free survival (LFS). To...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Champlin RE,Passweg JR,Zhang MJ,Rowlings PA,Pelz CJ,Atkinson KA,Barrett AJ,Cahn JY,Drobyski WR,Gale RP,Goldman JM,Gratwohl A,Gordon-Smith EC,Henslee-Downey PJ,Herzig RH,Klein JP,Marmont AM,O'Reilly RJ,Ringdén O,Slav

    更新日期：2000-06-15 00:00:00