Abstract：
OBJECTIVES:The present study reports the clinical and histological features of 14 cases of prostate adenocarcinoma coupled with their expression of the TGF isoforms beta2 and beta3, as well as their receptor endogline (CD105). METHODS:Fourteen (14) cases of adenocarcinoma (ADC) of the prostate were examined. Relevant clinical data were gathered From the histological point of view, the tumor's grade and the evidence of perineural, vascular and/or lymphatic invasion were the key elements taken into account. Immunohistochemical analyses were carried out to assess the expression of TGFbeta-2, TGFbeta-3 and CD105 in tumoral tissue samples. RESULTS:Patient's age ranged between 57 and 74 years. Thirteen (13) had prostatic specific antigen (PSA) values above the 4 ng/dL threshold Eleven (11) ADCs were moderately differentiated. The predominant grade in relation to the nucleus was II/III (7 cases). In two (2) of the 14 cases, no grading classification was applicable as the tumors exhibited changes related to the effect of hormonal therapy. In eleven cases, expression of TGFbeta-2 was detected in the cytoplasm of tumoral cells. Two cases also showed focal expression of TGFbeta-3, as well as in prostatic intraepithelial neoplasia areas of a third case. The areas with the highest intensity of expression were those occupied by basal cells and regions of glandular atrophy. These were also the areas of CD105 expression. CONCLUSIONS:Our results allow us to conclude that the TGF-beta3 family of cytokines, particularly the isoforms beta-2 and beta-3, seem to play a key role in the initiation, progression and transformation of tumoral cells inprostatic ADC. Future studies should be directed to the full understanding of the impact that these factors exert on tumoral behaviour, with an emphasis on those steps susceptible to therapeutic manipulation.
journal_name
Arch Esp Uroljournal_title
Archivos espanoles de urologiaauthors
Parada D,Arciniegas E,Moreira O,Trujillo Esubject
Has Abstractpub_date
2004-01-01 00:00:00pages
93-9issue
1eissn
0004-0614issn
1576-8260journal_volume
57pub_type
杂志文章abstract：OBJECTIVES:An additional case of leiomyosarcoma of the renal vein is presented and the literature reviewed. METHODS/RESULTS:The patient had a history of hypertension. He and his brother were the first case of twins with bilateral retinoblastoma reported in the literature. The pathological findings were diagnostic of l...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:Since its introduction more than 40 years ago, adjuvant treatment with BCG (Bacillus Calmette-Guérin) for non-muscle invasive bladder cancer (NMIBC) continues to be the treatment recommended in the highrisk group, and one of the most successful immunotherapies for cancer treatment. However, up to 20% of patients will ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Serotonin and norepinephrine systems are involved in the neural control of lower urinary tract function. The aim of this study was to compare the response on striated anal sphincter electromyographic (SAS-EMG) activity and cystometric parameters, when duloxetine and clomipramine were intravenously administrat...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142006000800019
更新日期：2006-10-01 00:00:00
abstract：:Currently, there are no guidelines for the selection of patients for caliceal stone removal, although there is no doubt that urologists are taking a more aggressive approach now that treatments with low morbidity are available. We discuss when and how to treat patients with symptomatic and asymptomatic caliceal stones...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVES:The value of ultrasonography for the study of female urinary incontinence has been redefined over the last years. METHODS:We review the literature about the value of ultrasound in the workup of females with urinary incontinence, mainly transperineal ultrasound for the female stress urinary incontinence (SUI...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：10.4321/s0004-06142006000400012
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:Erectile dysfunction is one of the sequelae after radical prostatectomy most concerning for the patient, its appearance being influenced by factors such as surgical technique, or patient's age. Thus, around 40% of the patients younger than 70 years and over 90% of the patients older than 70 present with erec...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:Genitalia trauma are relatively frequent pediatric emergencies. There is a wide spectrum of lesions that can be produced. The purpose of this study is to descriptively analyse our experience with pediatric urologic trauma over the last five years. METHODS:We review 152 cases of male children ages 1 to 15 yea...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Robotic radical prostatectomy is fast getting popular as an alternative to the open and laparoscopic radical prostatectomy. Planning for port placement and the assistant's role are the two crucial yardsticks for the success of this procedure. Ideal port placement for radical robotic prostatectomy is not only crucial f...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142007000400008
更新日期：2007-05-01 00:00:00
abstract：:Management of complex female urethral injuries is challenging. We present our experience of 9 cases over the last 3 years with a mean follow-up of 14 months. The spectrum of clinical problems and results of various forms of innovative management are highlighted. Injuries which could not be managed by primary repair or...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:We report a case of renal polar infarction in a 13-year old boy following surgical excision of contralateral congenital lobar emphysema. Patient history was unremarkable and yielded no data suggestive of any other underlying pathology or systemic disease. The diagnosis was made on the CT, arteriography and DMSA scan f...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:We report on a pediatric patient who was evaluated for recurrent episodes of urinary tract infection. Evaluation by IVP, cystography and retrograde ureteropyelography revealed a complete ureteral duplicity, grade II vesicoureteral reflux in the lower half of the left kidney and a blind bifid ureter arising at the dist...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVES:To discuss the modern imaging techniques and preoperative management of pheochromocytoma and to report on one additional case. METHODS:A 66-year-old male with an incidentally discovered left adrenal mass is described. The adrenal medulla strongly accumulate 131 I-metaiodobenzylguanidine (MIBG). The patient ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE OF THE REVIEW:Robot assisted Radical prostatectomy (RARP) has generated a new trend in the binomial teaching/learning, grouping these techniques in training modules such as theoretical learning, practice, personalized counseling, and modern tools like simulation and practice in virtual models. This review sum...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:To perform a bibliographic review of the laparoscopic approach for radiofrequency ablation of small renal masses. METHODS:For this review we used the Medline database. We reviewed the clinical guidelines of the American Urological Association, the European Association of Urology and other institutions. RES...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To review our series of hypospadias. The incidence of the different types of hypospadias and the complication rates according to the different surgical techniques and materials utilized are analyzed. METHODS:We reviewed our series of 130 patients with hypospadias who underwent surgical correction at the Depa...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:To report two rare cases of persistent müllerian duct syndrome. METHODS/RESULTS:Two patients with normal chromosome studies (46, XY) are presented. The radiological evaluation showed structures compatible with those of the müllerian duct. These structures were completely excised with excellent results. The h...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:The recto-vesical fistula (FRV) that follows a radical prostatectomy is an unusual complication and involves a difficult management. A wide variety of surgical aggressive repair techniques are described in literature, including end-colostomy. Furthermore, non-invasive procedures are barely documented. We pres...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:To determine the type and to quantify the DURR phenomena in the male. METHODS:We conducted a clinical and urodynamic study in 31 male patients with functional lower urinary tract symptoms. RESULTS:DURR is produced by two types of mechanisms: urethral rigidity and contraction of the urethral wall. The patie...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:The efficacy and morbidity of transurethral resection of the prostate (TURP) were evaluated in patients with urinary retention and prostatic carcinoma. METHODS:From 1990 to 1993, 30 patients with infravesical obstruction secondary to prostate cancer were treated by TURP. The results were considered good whe...
journal_title：Archivos espanoles de urologia
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVES:To evaluate the clinical and laboratory findings in pediatric patients with urolithiasis in a case control study and to obtain variables predicting a low risk of having urolithiasis. METHODS:Retrospective analysis of 24 cases of children with urolithiasis (age range 3 to 17 years old) admitted to the pediat...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142006000900005
更新日期：2006-11-01 00:00:00
abstract：:Urological surgery is rapidly developing towards less invasive and more conservative approaches without detriment to its proven efficacy. The authors, who perform endourologic surgery in 60% of the cases, have sought to enhance endoscopic suture techniques in the bladder using the triangulation procedure. Investigatio...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Endometriosis is relatively frequent in females of menstrual age and consists in the appearance of active endometrial tissue at sites other than the uterine cavity (genital system or adjacent organs). Endometrial tissue has been described to colonize the urinary system, particularly the urinary bladder. The most commo...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:The results of treatment of urethral strictures using the Sachse urethrotome in 31 patients are presented. These patients had consulted between 1985 and 1990 and were followed for a minimum of 6 months. The most common etiology in our series was iatrogenic (57.57%), particularly incorrect catheter placement. Single (6...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：OBJECTIVE:An uncommon complication of prostatic transrectal biopsy is described. METHODS/RESULTS:A case of peritonitis arising from a recto-peritoneal fistula after transrectal biopsy of the prostate is reported. The patient presented symptoms of peritonitis 15 days after undergoing ambulatory transrectal prostatic bi...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Introduction of retrograde flexible ureteroscopy represented a leap forward in upper urinary tract endourology. Nowadays, areas of the pyelocaliceal system accessible otherwise only by percutaneous or open surgery, can be approached in a retrograde fashion, using the anatomical pathways. The flexible ureteroscopes evo...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:The aim of this review is to evaluate the place of transurethral resection of the prostate (TURP) in patients with elevated and/or rising prostate specific antigen (PSA). The role of TURP in these patients is assessed in symptomatic as well as in asymptomatic patients. METHODS:Current literature (1987-2009)...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVES:To update the topic of endourethral prosthesis for the treatment of recurrent urethral stenosis comprehensively, focusing on current indications, materials and types of prosthesis in use nowadays. METHODS:We used the PubMed database (1995-2013) with the terms "endourethral ", "prostheses","endourethral pros...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To report on a patient who underwent surgery for renal carcinoma at the age of 12 years and who is alive and symptom-free after 22 years. METHODS:A 34-year-old female who underwent surgery for a right renal tumor when she was 12 is described. The histological analysis demonstrated renal adenocarcinoma. To da...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVES:Crossed fused renal ectopia is a rare congenital anomaly. We report the case of a 3 year old boy with diagnosis of right crossed fused renal ectopia, history of recurrent urinary tract infection and previous failure of surgical treatment. METHODS:Three year old boy with diagnosis of right crossed fused rena...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:To move towards a more standardized approach in clinical practice to manage patients with castration-resistant prostate cancer (CRPC) in Spain. METHODS:A panel of 18 Spanish experts in Urology with expertise managing CRPC followed a modified Delphi process with two rounds and a final face-to-face consensus ...
journal_title：Archivos espanoles de urologia
pub_type： 共识发展会议,杂志文章
doi：
更新日期：2017-11-01 00:00:00
