Abstract:
BACKGROUND:Previous studies have suggested that occupational exposure to styrene is associated with increased serum levels of the anterior pituitary hormone prolactin (PRL). AIMS:To test the hypotheses that: (1) the effect of styrene exposure on PRL secretion is an acute effect, not a subchronic or chronic effect; (2) blood styrene, as a measure of absorbed dose, is a stronger predictor of serum PRL level than personal breathing zone air styrene concentration. METHODS:Subjects were recruited from 17 workplaces in the reinforced plastics industry. Personal breathing zone air styrene, whole blood styrene, and serum PRL were measured during one to three sessions, approximately one year apart. Linear multiple regression was used to model the relations between acute (air styrene or blood styrene obtained at same time as PRL), subchronic (average air or blood styrene over two or three sessions), and chronic (years of work in industry or facility times average air styrene over all sessions) indices of styrene exposure and serum PRL. RESULTS:Acute blood styrene concentration was the strongest predictor of serum PRL concentration, with the model predicting a 2.06-fold increase in PRL (95% CI 1.11 to 3.84) for every 10-fold increase in blood styrene. Serum PRL tended to increase with increasing styrene exposure in both men and women; however, women tended to have higher PRL levels. For women, the change in blood styrene between sessions 1 and 2 was a significant predictor of the change in serum PRL between sessions. CONCLUSIONS:Results confirm that styrene exposure enhances serum PRL concentrations and support an acute effect of styrene on PRL secretion.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Luderer U,Tornero-Velez R,Shay T,Rappaport S,Heyer N,Echeverria Ddoi
10.1136/oem.2002.005561subject
Has Abstractpub_date
2004-04-01 00:00:00pages
325-33issue
4eissn
1351-0711issn
1470-7926journal_volume
61pub_type
杂志文章abstract:OBJECTIVES:To investigate the frequency, circumstances, and causes of occupational accidents aboard merchant ships in international trade, and to identify risk factors for the occurrence of occupational accidents as well as dangerous working situations where possible preventive measures may be initiated. METHODS:The s...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.2.85
更新日期:2002-02-01 00:00:00
abstract::: This systematic review and meta-analysis aimed to examine whether working beyond the standard working hours was associated with a greater risk of depressive disorder among workers included in published prospective studies. This manuscript was prepared according to the PRISMA guideline checklist. A database search wa...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-12-01 00:00:00
abstract:AIMS:To determine obstacles for return-to-work in disability management of low back pain patients sicklisted for 3-4 months. METHODS:A cohort of 467 low back pain patients sicklisted for 3-4 months was recruited. A questionnaire was sent to their occupational physicians (OPs) concerning the medical management, obstacl...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:Rhinitis is common, but the risk factors are not well described. To investigate the association between current rhinitis and pesticide use, we used data from 2245 Iowa commercial pesticide applicators in the Agricultural Health Study. METHODS:Using logistic regression models adjusted for age, education and ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.041798
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:To determine the kinetics of elimination of urinary dialkylphosphate metabolites after oral and dermally applied doses of the organophosphate pesticide chlorpyrifos to human volunteers and to determine whether these doses affected plasma and erythrocyte cholinesterase activity. METHOD:Five volunteers ingest...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.1.10
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abstract:OBJECTIVE:This study was undertaken to assess whether contaminated personal clothing worn beneath a coverall (normal workwear) is a source of potentially significant dermal exposure to polycyclic aromatic hydrocarbons (PAHs) in coal liquefaction workers. METHODS:An intervention study was conducted over a two week peri...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/oem.52.9.600
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:This study investigated determinants of bone and blood lead concentrations in 430 lactating Mexican women during the early postpartum period and the contribution of bone lead to blood lead. METHODS:Maternal venous lead was measured at delivery and postpartum, and bone lead concentrations, measured with in vi...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.8.535
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVES:To investigate the effectiveness of a counselling and education programme on work ability and work disability pension for employees in the construction industry. METHODS:Employees with a high disability risk of 38% or more in the following four years were included. Employees in the intervention group were e...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章
doi:10.1136/oem.2006.029678
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:Endotoxin-exposed workers are at an increased risk of non-atopic asthma and lung-function decline. Genetic variants may influence susceptibility to these effects. The objective of the present study was to assess whether the association between occupational endotoxin exposure and wheeze is modified by innate ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.060038
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:There is limited research concerning how small companies in particular, respond to health and safety messages. AIMS:To understand individuals' knowledge and beliefs about chemical risks and to compare these with those of experts. METHODS:The use of chromic acid in particular, and also other chemicals assoc...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.10.689
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leukaemia because of chronic exposure to several potential carcinogens. METHODS:The Italian SETIL study (Study on the aetio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101604
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:To determine the mortality from non-respiratory cancers by work area among active and retired male workers of the German rubber industry. METHODS:A cohort of 11,633 male German workers was followed up for mortality from 1 January 1981 to 31 December 1991. Cohort members were active (n = 7536) or retired (n ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.5.325
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To estimate the fraction of carpal tunnel syndrome (CTS) that is attributable to work in the total adult population of the island of Montreal. METHODS:The population consisted of 1.1 million people 20-64 years of age, with 73.2% of men and 60.6% of women employed. The rates of first surgery for CTS were comp...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.7.519
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVES:Mental disorders are associated with significant functional impairment, sickness absence and disability. The consequences of sickness absence warrant investigation into interventions aimed at enhancing return to work (RTW) for workers with mental disorders. The present systematic review and meta-analysis aim...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oemed-2018-105073
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether changes in objective working hour characteristics are associated with parallel changes in work-life conflict (WLC) among hospital employees. METHODS:Survey responses from three waves of the Finnish Public Sector study (2008, 2012 and 2015) were combined with payroll data from 91 days p...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104785
更新日期:2018-06-01 00:00:00
abstract:AIMS:To examine the relation between the psychosocial work environment and the perceived indoor air problems measured by a questionnaire survey; and to discuss the role of a questionnaire as a means to enhance collaboration in the challenging multiprofessional process of solving indoor air problems. METHODS:The resear...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2002.005835
更新日期:2004-02-01 00:00:00
abstract:AIMS:To test whether (1) physically demanding work is less frequent for older than younger employees, and whether (2) the association of physically demanding work with decline of physical functioning is stronger for older employees than their younger counterparts. The gender differences in these associations were exami...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014035
更新日期:2005-02-01 00:00:00
abstract:INTRODUCTION:The current definition of chronic obstructive pulmonary disease (COPD) associates persistent airflow limitation and chronic respiratory symptoms. Agricultural work has been associated with an increased risk of developing COPD, but the prevalence and definition of the disease vary greatly between studies. T...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oemed-2018-105310
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:This study estimated the prevalence of spirometry-defined airflow obstruction and coal workers' pneumoconiosis (CWP) among never-smoking coal miners participating in the National Institute for Occupational Safety and Health (NIOSH) Coal Workers' Health Surveillance Program (CWHSP). METHODS:Data were from ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.12.962
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To assess whether the increased risk of disease related to asbestos in occupations from the construction and engineering industries applies equally to pleural cancer, peritoneal cancer, and asbestosis. METHODS:Analysis was based on deaths among men aged 20-74 in England and Wales during 1979-80 and 1982-90. ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.11.775
更新日期:1995-11-01 00:00:00
abstract:AIMS:To determine the cancer incidence in Swedish cabin crew. METHODS:Cancer incidence of cabin crew at the Swedish Scandinavian Airline System (SAS) (2324 women and 632 men) employed from 1957 to 1994 was determined during 1961-96 from the Swedish National Cancer Register. The cancer incidence in cabin crew was compa...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.810
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of enzyme sensitisation in the animal feed industry. METHODS:A cross sectional study was conducted in four animal feed factories, where several enzymes had been used in powder form for 7-9 years. Before this study, enzymes in liquid form had started to be used. Sensitisation to enzy...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.2.119
更新日期:2001-02-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2009.052506
更新日期:2011-06-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.012492
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To estimate the occurrence of hand eczema in hairdressers in Sweden. METHODS:The occurrence of hand eczema was estimated in a Swedish longitudinal retrospective cohort study including all female graduates from vocational schools for hairdressers from 1970 to 1995. A stratified sample from the general populat...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.026211
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:To investigate the possible interactions between physical and psychosocial risk factors at work that may be associated with self reported back disorders. METHODS:891 of 1514 manual workers, delivery drivers, technicians, customer services computer operators, and general office staff reported risk factors at...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.5.343
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:The mortality experience of 4702 (4413 men and 289 women) civilian workers in a US Coast Guard shipyard was evaluated. METHODS:All workers employed at the shipyard between 1 January 1950 and 31 December 1964 were included in the study and were followed through 31 December 2001 for vital status. Detailed shi...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.029652
更新日期:2007-10-01 00:00:00
abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.882
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:Self-reported exposure to vapours, gas, dust or fumes (VGDF) has been widely used as an occupational exposure metric in epidemiological studies of chronic lung diseases. Our objective was to characterise the performance of VGDF for repeatability, systematic misclassification, and sensitivity and specificity ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.040022
更新日期:2009-03-01 00:00:00