Abstract:
:Birth cohorts that collect detailed phenotypic and environmental information, particularly if multigenerational, have an important contribution to make as we seek to understand the genetic and environmental determinants of common disease. Provided such multigenerational population cohorts are unselected by disease, trait or exposure, they can also contribute important information that is needed for optimal statistical analysis in genetic epidemiology generally. One example of this added value is an assessment, at specified loci, of whether or not there is distortion of the expected Mendelian 50 : 50 transmission of alleles to study subjects (e.g. due to differential loss of embryos of one genotype). Another example is to test for heterosis, i.e. whether heterozygotes have a greater or lesser effect than either homozygote. Finally, phenome scans (a fixed format analysis of the associations between a genotype of interest and thousands of outcome variables from the cohort database) could be used as a screening tool to test whether certain classes of genetic variation have more impact than others on human health and development, and so inform genotyping strategies generally.
journal_name
Paediatr Perinat Epidemioljournal_title
Paediatric and perinatal epidemiologyauthors
Pembrey Mdoi
10.1111/j.1365-3016.2004.00530.xsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
3-7issue
1eissn
0269-5022issn
1365-3016pii
530journal_volume
18pub_type
杂志文章,评审abstract::In this study, hospital admissions for lower respiratory tract illness before two years of age have been documented for all children born in Western Australia in 1986. Admissions data were linked to birth and death records for individual children. Of the total cohort, 5% of non-Aboriginal and 17% of Aboriginal childre...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1996.tb00041.x
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:To investigate whether the adverse infant health outcomes associated with early birth and severe neonatal morbidity (SNM) persist beyond the first year of life and impact on paediatric hospitalisations for children up to 6 years of age. METHODS:The study population included all singleton live births, >32 we...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12188
更新日期:2015-05-01 00:00:00
abstract::Percentiles of weight-by-gestational age were constructed for first and second births, based on linked sibship-data from the Medical Birth Registry of Norway. Standards were made for weight-by-gestational age of second births conditional on whether the first birth was small-for-gestational age (SGA) or large-for-gesta...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1989.tb00531.x
更新日期:1989-10-01 00:00:00
abstract::Recurrence risk provides information on the heterogeneity of risk in the population, and thus is useful for aetiological studies. While recurrence risk is observable in many areas of epidemiology, it is particularly accessible in the study of perinatal events. High recurrence rates of pregnancy problems suggest geneti...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2007.00830.x
更新日期:2007-07-01 00:00:00
abstract::A cohort of children born after assisted reproductive technologies (ART) was set up in 2003 in Italy. It aims to follow up the children in order to study the short- and long-term effects of ART. Parents who agreed to participate were contacted for a telephone interview; questions included occupational and non-occupati...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-3016.2006.00734.x
更新日期:2006-09-01 00:00:00
abstract::Singleton survivors born to multigravidae in the whole island of Jamaica in 2 months (September-October 1986) were compared with singleton perinatal deaths occurring to multigravidae throughout the island in the 12-month period September 1986 to August 1987. Past obstetric history was obtained from the mothers using a...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1994.tb00490.x
更新日期:1994-04-01 00:00:00
abstract::Passive smoking during pregnancy leads to adverse effects on mother and infant. The present investigation was designed to evaluate the association between maternal reported passive smoking with the cotinine concentration of maternal urine and umbilical cord blood at delivery and to determine the accuracy of maternal r...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2011.01242.x
更新日期:2012-01-01 00:00:00
abstract::The perinatal mortality rate (PMR) in twins was analysed using Japanese vital statistics during the period 1980-98. There was a total of 1992 twin perinatal deaths. The PMR in twins significantly decreased from 91 per 1000 births in 1980 to 31 per 1000 in 1998. The PMR was higher in males than females, but the differe...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2001.00361.x
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Recently, the Chinese government has promoted preconception care (PCC) to prevent birth defects. The objective of this study was to evaluate the implementation of PCC in Shanghai, China, following a 3-year municipal project providing 'Free Pre-pregnancy Health Evaluation Services' to 20 000 residents. METHO...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1111/ppe.12218
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:While there is evidence of an association between caesarean birth and increased asthma in children in high-income countries, it is unknown whether this association exists in low-to-middle-income countries (LMICs). We investigated whether children born through caesarean in India and Vietnam are at increased r...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12324
更新日期:2017-01-01 00:00:00
abstract::Longer-term follow-up of infants with specific health concerns, such as low birthweight, is critical to assessing the effect of medical interventions. This report examines the approach of reconstructing previously studied cohorts in terms of the factors discriminating between respondents and non-respondents. Follow-up...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1991.tb00727.x
更新日期:1991-10-01 00:00:00
abstract::A prospective study of 4934 babies of different ethnic groups has confirmed the high perinatal mortality rate for Pakistanis and has shown that this was not due to a reluctance to terminate a fetus who is known to be seriously malformed. The major cause of early mortality was a high rate of lethal malformations, which...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1991.tb00689.x
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Bariatric procedures are on the rise. The risk of birth defects in pregnancies following such procedures may be increased (eg, due to nutrient deficiencies) or decreased (eg, due to decreased maternal body mass index, BMI). METHODS:We conducted a systematic literature review of the association between baria...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12517
更新日期:2018-11-01 00:00:00
abstract::Designing, piloting and proceeding with a longitudinal birth cohort is a major exercise. Here we outline ways in which a resource centre could be initiated to provide advice and training, a library of appropriate instruments and publications, provision for cross-cohort comparisons and a biobanking facility. The resour...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2009.01020.x
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Stress during pregnancy is known to affect fetal neurodevelopment. It seems likely therefore that intimate partner violence (IPV) and domestic violence (DV) as extreme stressors will have a similarly adverse effect. OBJECTIVES:A systematic review was conducted to assess the association between prenatal expo...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,评审
doi:10.1111/ppe.12651
更新日期:2020-03-01 00:00:00
abstract::Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide exposure of people living near agricultural fields. This systematic review evaluates the current epidemiological evidence on the association between living near ag...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3016.2010.01165.x
更新日期:2011-03-01 00:00:00
abstract::The aim of this paper is to estimate the infant mortality rate and the incidence of sudden infant death syndrome (SIDS) in Lombardy, Northern Italy, in the period 1990-2000 and to provide basic information for a subsequent comparison of the SIDS incidence before and after the risk-intervention campaign. A retrospectiv...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2004.00583.x
更新日期:2004-09-01 00:00:00
abstract::This report describes a cohort study of over 5000 infants and their mothers who participated in a cord blood serosurvey designed to examine the relationship between maternal exposure to Lyme disease and adverse pregnancy outcome. Based on serology and reported clinical history, mothers of infants in an endemic hospita...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1995.tb00148.x
更新日期:1995-07-01 00:00:00
abstract::Social differences in late fetal death and infant mortality were examined in a population-based prospective study. All singletons born to Nordic citizens in Sweden 1985-86 were included, 185,156 births in all. The overall rates of late fetal death and infant mortality were 3.5 and 5.3 per 1000 respectively. Socio-econ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1993.tb00599.x
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:A few studies have indicated an increased risk of epilepsy in children conceived by fertility treatment possibly due to characteristics of the infertile couple rather than the treatment. We therefore aimed to investigate the association between parental infertility, fertility treatment, and epilepsy in the o...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12301
更新日期:2016-09-01 00:00:00
abstract::Cognitively delayed children are at risk for poor mental and physical health throughout their lives. The economically disadvantaged and some race/ethnic groups are more likely to experience cognitive delay, but the age at which delays first emerge and the underlying mechanisms responsible for disparities are not well ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2008.01006.x
更新日期:2009-05-01 00:00:00
abstract::Development of the perineum as well as the external genitalia is determined by dihydrotestosterone, resulting in a greater anogenital distance (AGD) in males than females. In animal experiments with hormonally active agents, anogenital distance is used as a bioassay of fetal androgen action. Use of anogenital distance...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-3016.2007.00810.x
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Many births in industrialised countries are to immigrant parents, or to one immigrant and one domestically born parent. Their newborn outcomes have not been well studied. METHODS:We conducted a study of 1,690,423 singleton infants born in Sweden between 1987 and 2008, including those of immigrants from East...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12179
更新日期:2015-03-01 00:00:00
abstract::We studied infant mortality rates in Canada within specific gestational age and birthweight categories after using probabilistic techniques to link information in Statistics Canada's live births data base (1985-94) with that in the death data base (1985-95). Gestational age- and birthweight-specific mortality rates in...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2000.00298.x
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Prepregnancy cardiometabolic risk factors are associated with increased risks of adverse pregnancy outcomes. Neighbourhood features may reflect prepregnancy exposures that contribute to poor cardiometabolic health before pregnancy and may contribute to racial disparities in pregnancy outcomes. METHODS:Early...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12531
更新日期:2019-01-01 00:00:00
abstract::A nationwide cross-sectional survey covering the perinatal period was attempted throughout Greece for the 30 consecutive days of April 1983. It aimed to determine the perinatal mortality rate (PNMR) and the way it varied in the country in relation to underlying demographic, biological, socioeconomic and medical factor...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1987.tb00088.x
更新日期:1987-04-01 00:00:00
abstract::The development of secondary enuresis was examined in a birth cohort of New Zealand children studied to the age of 10 years. By this age, 7.9% of children had developed secondary enuresis. Analysis suggested two risk factors were involved in secondary enuresis. First, children who were late to attain nocturnal bladder...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1990.tb00618.x
更新日期:1990-01-01 00:00:00
abstract::Preterm delivery (PTD) complicates as many as 10% of pregnancies in the United States. Moreover, prematurity accounts for more than 70% of the consequent neonatal and infantile morbidity and mortality. Serious long-term complications include cerebral palsy, respiratory disease, blindness and deafness. Despite substant...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-3016.2001.00008.x
更新日期:2001-07-01 00:00:00
abstract::Air pollution from vehicular emissions and other combustion sources is related to cardiovascular and respiratory outcomes. However, few studies have investigated the relationship between air pollution and preterm birth, a primary cause of infant mortality and morbidity. This analysis examined the effect of fine partic...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2006.00759.x
更新日期:2006-11-01 00:00:00
abstract::Necrotising enterocolitis is the most common gastrointestinal complication of pre-term infants. In order to determine the strength of the association of hypoxia/ischaemia and infection as causative factors in necrotising enterocolitis, we evaluated all liveborn pre-term infants with a birthweight less than 1500 g and/...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3016.1989.tb00369.x
更新日期:1989-01-01 00:00:00