[Allorecognition of the recipient after hematopoietic transplantation].

Abstract:

:Donor allorecognition of the recipient after hematopoietic transplantation can result in graft-versus-host disease, a potent graft-vs-leukemia effect as well as a graft facilitation effect. Danger signals, host Ag-presenting cells and minor histocompatibility Ag have recently emerged as major determinants of such an alloreactivity. A better understanding of the involved immune mechanisms, the development of novel immunomonitoring tools and cell engineering approaches should result in a significantly increased therapeutic index of allogeneic alloreactivity.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Tiberghien P,Robinet E,Ferrand C,Saas P,Hervé P

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

706-10

issue

8-9

eissn

0007-4551

issn

1769-6917

journal_volume

90

pub_type

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