Loss of circulating CD27+ memory B cells and CCR4+ T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection.

abstract：:Acute myeloid leukemia (AML) cells are characterized by unlimited self-renewal and an impaired capacity to undergo terminal differentiation. The MUC1 oncoprotein is aberrantly expressed in AML cells; however, there has been no evidence for involvement of MUC1 in myeloid leukemogenesis. Cell-penetrating peptide inhibit...

journal_title：Blood

authors： Yin L,Wu Z,Avigan D,Rosenblatt J,Stone R,Kharbanda S,Kufe D

更新日期：2011-05-05 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is expressed in almost all types of malignancies, making this protein a useful tool for the development of broadly applicable vaccination therapies. We used a recently identified HLA-A2 binding peptide and dendritic cells (DCs) from healthy donors to ind...

journal_title：Blood

authors： Schmidt SM,Schag K,Müller MR,Weck MM,Appel S,Kanz L,Grünebach F,Brossart P

更新日期：2003-07-15 00:00:00

abstract：:Potassium tellurite (K2TeO3) was found to be a potent antisickling agent that inhibited red cell sickling at concentrations less than 10 mumol/L. The inhibitory effect depended on the incubation time, with the effect increasing with longer incubation periods. Because tellurite causes swelling of red cells, and because...

journal_title：Blood

authors： Asakura T,Shibutani Y,Reilly MP,DeMeio RH

更新日期：1984-07-01 00:00:00

abstract：:The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation...

journal_title：Blood

authors： Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F

更新日期：2012-05-03 00:00:00

abstract：:Neuropilin-1 (Npn-1) is a receptor shared by class 3 semaphorins and heparin-binding forms of vascular endothelial growth factor (VEGF), protein families that regulate endothelial and neuronal-cell function. Ligand interaction with Npn-1 dictates the choice of signal transducer; plexins transduce semaphorin signals, a...

journal_title：Blood

authors： Narazaki M,Tosato G

更新日期：2006-05-15 00:00:00

abstract：:Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not found in the...

journal_title：Blood

authors： Fang B,Zheng C,Liao L,Han Q,Sun Z,Jiang X,Zhao RC

更新日期：2005-04-01 00:00:00

abstract：:Cellulose ester membranes (CEM) were coated with stromal cells from bone marrow (BM) or bone and implanted intraperitoneally (IP) in CAF1 mice for intervals of 1 to 6 months. Previous studies indicated that matrix factors [glycoproteins (GPs), proteoglycans (PGs), and glycosaminoglycans (GAGs)] were secreted by the re...

journal_title：Blood

authors： Knospe WH,Husseini SG,Fried W

更新日期：1989-07-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disease caused by mutations in the WAS gene, leading to thrombocytopenia, eczema, recurrent infections, autoimmune disease, and malignancy. Hematopoietic cell transplantation (HCT) is the primary curative approach, with the goal of correcting the underlying immunodeficienc...

journal_title：Blood

authors： Burroughs LM,Petrovic A,Brazauskas R,Liu X,Griffith LM,Ochs HD,Bleesing JJ,Edwards S,Dvorak CC,Chaudhury S,Prockop SE,Quinones R,Goldman FD,Quigg TC,Chandrakasan S,Smith AR,Parikh S,Dávila Saldaña BJ,Thakar MS,Phela

更新日期：2020-06-04 00:00:00

abstract：:Hematopoiesis is a tightly regulated process resulting in the production of blood cells. Self-renewal and differentiation of hematopoietic stem cells (HSCs) are key processes in hematopoietic development. Disruption of these steps can lead to altered cell distribution and disease. To investigate the role of the nuclea...

journal_title：Blood

authors： Stein SJ,Baldwin AS

更新日期：2013-06-20 00:00:00

abstract：:Hypersensitivity to cross-linking agents and predisposition to malignancy are characteristic of the genetically heterogeneous inherited bone marrow failure syndrome, Fanconi anemia (FA). The protein encoded by the recently cloned FA complementation group A gene, FAA, has been expected to localize in the nucleus as bas...

journal_title：Blood

authors： Kruyt FA,Waisfisz Q,Dijkmans LM,Hermsen MA,Youssoufian H,Arwert F,Joenje H

更新日期：1997-11-01 00:00:00

abstract：:Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the cell surface. Mutations in FH and MCP are linked to atypical hemolytic...

journal_title：Blood

authors： Ueda Y,Mohammed I,Song D,Gullipalli D,Zhou L,Sato S,Wang Y,Gupta S,Cheng Z,Wang H,Bao J,Mao Y,Brass L,Zheng XL,Miwa T,Palmer M,Dunaief J,Song WC

更新日期：2017-03-02 00:00:00

abstract：:Adaptive immunity is triggered at the immune synapse, where peptide-major histocompatibility complexes and costimulatory molecules expressed by dendritic cells (DCs) are physically presented to T cells. Here we describe transmission of the inflammatory monoamine serotonin (5-hydroxytryptamine [5-HT]) between these cel...

journal_title：Blood

authors： O'Connell PJ,Wang X,Leon-Ponte M,Griffiths C,Pingle SC,Ahern GP

更新日期：2006-02-01 00:00:00

abstract：:It was previously shown that patients with chronic myeloid leukemia (CML) have a rare but consistently detectable population of quiescent (G0) leukemic (Philadelphia chromosome-positive and BCR-ABL-positive [BCR-ABL+]) CD34+ cells. In the study described here, most such cells expressed a primitive phenotype (CD38-, CD...

journal_title：Blood

authors： Holyoake TL,Jiang X,Jorgensen HG,Graham S,Alcorn MJ,Laird C,Eaves AC,Eaves CJ

更新日期：2001-02-01 00:00:00

abstract：:Glycoprotein VI (GPVI) is an essential platelet receptor for collagens that is exclusively expressed in the megakaryocytic lineage. Transcription of the human gene GP6 is driven largely by GATA-binding protein 1 (GATA-1), specificity protein 1 (Sp1), and Friend leukemia integration 1 (Fli-1). In this report, we show t...

journal_title：Blood

authors： Kanaji S,Kanaji T,Jacquelin B,Chang M,Nugent DJ,Komatsu N,Moroi M,Izuhara K,Kunicki TJ

更新日期：2005-05-15 00:00:00

abstract：:In this issue of Blood, Roach and colleagues show that individuals with prior superficial venous thrombosis are at increased risk of developing venous thromboembolism when exposed to acquired clinical risk factors. ...

journal_title：Blood

authors： Bates SM

更新日期：2013-12-19 00:00:00

abstract：:The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...

journal_title：Blood

authors： Swimm A,Giver CR,DeFilipp Z,Rangaraju S,Sharma A,Ulezko Antonova A,Sonowal R,Capaldo C,Powell D,Qayed M,Kalman D,Waller EK

更新日期：2018-12-06 00:00:00

abstract：:Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF) stimulates TEC proliferation and, when given preconditioning, reduces TEC injury. Thymocytes and TECs express androgen receptors, and expo...

journal_title：Blood

authors： Kelly RM,Highfill SL,Panoskaltsis-Mortari A,Taylor PA,Boyd RL,Holländer GA,Blazar BR

更新日期：2008-06-15 00:00:00

abstract：:The expression of a number of blood coagulation factors (F) (FX, FIX, FVIII, FVII, alpha-, beta-, gamma-fibrinogen chains, protein C, and antithrombin III [AT III]) was analyzed at RNA and protein level in 5- to 10-week-old human embryos and fetuses. FX, FIX, and FVII were also analyzed at protein level. Total and pol...

journal_title：Blood

authors： Hassan HJ,Leonardi A,Chelucci C,Mattia G,Macioce G,Guerriero R,Russo G,Mannucci PM,Peschle C

更新日期：1990-09-15 00:00:00

abstract：:Little is known about the behavior of hematopoietic stem cells (HSCs) in primates because direct observations and competitive-repopulation assays are not feasible. Therefore, we used 2 different and independent experimental strategies, the tracking of transgene expression after retroviral-mediated gene transfer (N = 1...

journal_title：Blood

authors： Shepherd BE,Kiem HP,Lansdorp PM,Dunbar CE,Aubert G,LaRochelle A,Seggewiss R,Guttorp P,Abkowitz JL

更新日期：2007-09-15 00:00:00

abstract：:Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischemic stroke (IS), or non-MI ischemic heart disease (non-MI-IHD). The design was 3 case-control studies ...

journal_title：Blood

authors： Juul K,Tybjaerg-Hansen A,Steffensen R,Kofoed S,Jensen G,Nordestgaard BG

更新日期：2002-07-01 00:00:00

abstract：:Hematopoietic suppression is one of the serious problems induced by whole body irradiation. Granulocyte colony-stimulating factor (G-CSF) stimulates the progenitors of granulocytes and accelerates their recovery from bone marrow suppression induced by cytotoxic chemotherapy or radiation. On the other hand, G-CSF stimu...

journal_title：Blood

authors： Kawase Y,Akashi M,Ohtsu H,Aoki Y,Akanuma A,Suzuki G

更新日期：1993-10-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) occurs frequently after hematopoietic stem cell transplantation (HSCT) and can lead to significant morbidity and mortality. There are no data addressing individual susceptibility to TA-TMA. We performed a hypothesis-driven analysis of 17 candidate genes known t...

journal_title：Blood

authors： Jodele S,Zhang K,Zou F,Laskin B,Dandoy CE,Myers KC,Lane A,Meller J,Medvedovic M,Chen J,Davies SM

更新日期：2016-02-25 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a tyrosine phosphoprotein highly expressed on endothelial cells and leukocytes, is an important component in the regulation of neutrophil transendothelial migration. Engagement of endothelial PECAM-1 activates tyrosine phosphorylation events and evokes prol...

journal_title：Blood

authors： O'Brien CD,Lim P,Sun J,Albelda SM

更新日期：2003-04-01 00:00:00

abstract：:The cellular immune defect in untreated Hodgkin's disease (HD) has long been recognized. This defect appears to be responsible for at least some of the morbidity and ultimately the mortality associated with the disease. In recent years, many studies have shown that the T cell component of the immune response is the ap...

journal_title：Blood

authors： Ford RJ,Tsao J,Kouttab NM,Sahasrabuddhe CG,Mehta SR

更新日期：1984-08-01 00:00:00

abstract：:Seventeen patients with therapy-related myelodysplastic syndrome (t-MDS) or therapy-related acute nonlymphocytic leukemia (t-ANLL) were treated with single-agent high-dose cytarabine (HDAC; 1 to 3 g/m2 every 12 hours for 12 doses). The initial neoplasm was still present in eight patients when t-MDS/t-ANLL developed. F...

journal_title：Blood

authors： Larson RA,Wernli M,Le Beau MM,Daly KM,Pape LH,Rowley JD,Vardiman JW

更新日期：1988-10-01 00:00:00

abstract：:Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute megakaryoblastic leukemia (AMKL), a form of acute myeloid leukemia. Unique to newborn infants with Down syndrome is a transient leukemia (TL), also referred to as transient myeloproliferative syndr...

journal_title：Blood

authors： Hitzler JK,Cheung J,Li Y,Scherer SW,Zipursky A

更新日期：2003-06-01 00:00:00

abstract：:Plasma glutathione peroxidase (GSHPx) (glutathione: H2O2 oxidoreductase) is a unique selenoglycoprotein. Treatment of this enzyme with glycopeptidase F partially deglycosylates it and establishes the presence of N-linked sugar moieties. Antibodies raised in a rabbit against the purified enzyme from plasma were found t...

journal_title：Blood

authors： Avissar N,Whitin JC,Allen PZ,Palmer IS,Cohen HJ

更新日期：1989-01-01 00:00:00

abstract：:We examined TP53 mutation in 57 patients with myelodysplastic syndrome (MDS) at either the MDS phase or at the terminal leukemic phase using polymerase chain reaction-mediated single-strand conformation polymorphism (PCR-SSCP) analysis. TP53 mutations within exons 5 through 8 were found in seven patients. All these mu...

journal_title：Blood

authors： Kaneko H,Misawa S,Horiike S,Nakai H,Kashima K

更新日期：1995-04-15 00:00:00

abstract：:Hemoglobin Ohio [beta 142 (H20) Ala replaced by Asp] was found in three members of a white family, all of whom showed erythrocytosis. The variant hemoglobin has a high oxygen affinity, a reduced Bohr effect, and diminished cooperativity. The functional abnormalities of Hb Ohio are explained by the proximity of the sub...

journal_title：Blood

authors： Moo-Penn WF,Schneider RG,Shih T,Jones RT,Govindarajan S,Govindarajan PG,Patchen LC

更新日期：1980-08-01 00:00:00

abstract：:Current dendritic cell (DC)-based vaccines are based on ex vivo-generated autologous DCs loaded with antigen prior to readministration into patients. A more direct and less laborious strategy is to target antigens to DCs in vivo via specific surface receptors. Therefore, we developed a humanized antibody, hD1V1G2/G4 (...

journal_title：Blood

authors： Tacken PJ,de Vries IJ,Gijzen K,Joosten B,Wu D,Rother RP,Faas SJ,Punt CJ,Torensma R,Adema GJ,Figdor CG

更新日期：2005-08-15 00:00:00