Abstract:
:In a previous study, we used a murine monoclonal antibody, A7, against human colon carcinoma as a drug-carrier to treat colorectal cancer. In the present study, we found that MAb A7 also reacted immunohistochemically with 73% of human pancreatic carcinoma cell lines, with the A7 antigen mainly being detected on the cell surface. However, the A7 antigen was found in only 9% of the spent media of these human pancreatic carcinoma cell lines by ELISA. On the other hand, the positive incidence of CA19-9, POA, ferritin, CEA, DU-PAN-2 and SLX in those spent media was 100%, 64%, 64%, 55%, 55% and 36%, respectively. These results suggest that the A7 antigen may only rarely be shed into the sera of pancreatic cancer patients, in which case MAb A7 could be a suitable drug-carrier in targeting chemotherapy for pancreatic cancer patients.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Otsuji E,Yamaguchi T,Yamaguchi N,Koyama K,Imanishi J,Yamaoka N,Takahashi Tdoi
10.1007/BF00308745subject
Has Abstractpub_date
1992-01-01 00:00:00pages
351-6issue
4eissn
0941-1291issn
1436-2813journal_volume
22pub_type
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