[Oral tegafur plus mitomycin versus intravesical mitomycin alone in the prevention of recurrence in stage Ta bladder tumors].

Abstract:

OBJECTIVE:The aim of this study is to know if the use of oral Tegafur associated to intravesical mitomycin is effective in the prevention of the relapses of Ta bladder tumors. METHOD:This is a prospective study in which we compare the recurrence rate and the disease-free interval of 2 groups of 40 patients each one, the first of them treated after the TUR with oral Tegafur and intravesical mitomycin, and the second with intravesical mitomycin alone. Tolerance of Tegafur was also studied. RESULTS:The group of the Tegafur presented a descent of the relapse rate and a continuation of the time free of illness; but it was not statistically significant. The tolerance to the drug was good, without important adverse effects. CONCLUSIONS:Tegafur seems an useful drug in the prevention of the recurrence of superficial bladder tumors, although it will be necessary bigger studies to reach statistically valid conclusions.

journal_name

Actas Urol Esp

authors

Server Pastor G,Rigabert Montiel M,Bañón Pérez V,Valdelvira Nadal P,Cao Avellaneda E,García Hernández JA,Pérez Albacete M

doi

10.1016/s0210-4806(03)72950-7

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

438-41

issue

6

eissn

0210-4806

issn

1699-7980

pii

S0210-4806(03)72950-7

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验
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