Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: a comprehensive alternative.


:Since the first report addressing quantification of cerebral blood flow (CBF), concomitant assessment of cerebral oxygen consumption was also carried out. Over the years, however, some investigators have emphatically and mistakenly addressed cerebral ischemia in comatose patients, on the basis of CBF measurements alone. In contrast, we have repeatedly reported that ischemia in these patients must be precisely evaluated based on CBF-metabolism coupling or uncoupling, rather than CBF alone. Based on these previous findings, we therefore propose a comprehensive alternative approach, namely the evaluation of brain ischemia in comatose patients based on cerebral metabolic parameters, such as cerebral extraction of oxygen or cerebral lactate release, without expensive CBF measurements.


Arq Neuropsiquiatr


Cruz J




Has Abstract


2003-06-01 00:00:00














  • Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy.

    abstract:OBJECTIVE:Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) enzyme levels were investigated in patients with epilepsy, epileptic seizure, remission period, and healthy individuals. METHODS:Three main groups were evaluated, including epileptic seizure, patients with epilepsy in the non-seizure period, and healthy volunteers. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Yasak IH,Yilmaz M,GÖnen M,Atescelik M,Gurger M,Ilhan N,Goktekin MC

    更新日期:2020-07-01 00:00:00

  • Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests: results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01).

    abstract:OBJECTIVE:To investigate the effects of galantamine on the performance of patients with mild to moderate Alzheimer's disease (AD) in a computerized neuropsychological test battery (CNTB). METHOD:Thirty-three patients with probable AD were treated with galantamine for three months and evaluated in a prospective, open-l...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Caramelli P,Chaves ML,Engelhardt E,Machado JC,Schultz RR,Vale FA,Charchat-Fichman H,Brazilian Multi-Center Galantamine Study (GAL-BRA-01).

    更新日期:2004-06-01 00:00:00

  • Désiré-Magloire Bourneville and his contributions to pediatric neurology.

    abstract::Désiré-Magloire Bourneville ought to be thought of as the father of Pediatric Neurology for his significant contributions to the field. He worked as a physician, politician, writer, and editor. He was the first to describe the autosomal dominant genetic condition known as "tuberous sclerosis complex", after conducting...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 传,历史文章,杂志文章


    authors: Gómez-López MT,Palacios-Sánchez L,Meerbeke AVV,Botero-Meneses JS

    更新日期:2019-05-13 00:00:00

  • HTLV-1 antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil.

    abstract::HTLV-1 antibodies were investigated in serum and in CSF of 150 patients with neurologic disorders mainly myelopathies. The patients were considered into three groups according to the possible relationship of their disease to the presence of HTLV-1 antibodies: no relationship risk (control group), occasional risk group...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Spina-França A,Livramento JA,Machado LR,Gomes HR,Vianna LS,Castro LH,Nóbrega JP,Bacheschi LA

    更新日期:1990-12-01 00:00:00

  • Molecular diagnosis of Huntington disease in Brazilian patients.

    abstract::Huntington disease (HD) is a progressive neurodegenerative disorder with autosomal dominant inheritance, characterized by choreiform movements and cognitive impairment. Onset of symptoms is around 40 years of age and progression to death occurs in approximately 10 to 15 years from the time of disease onset. HD is asso...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Lima E Silva TC,Serra HG,Bertuzzo CS,Lopes-Cendes I

    更新日期:2000-03-01 00:00:00

  • Nervous system cancer mortality in an industrialized area of Brazil 1980-1993.

    abstract:OBJECTIVES:The industrialization process and nervous system cancer (NSC) mortality in a urban region of Brazil. METHOD:From registries of the State System of Data Analysis Foundation (SEADE), 103 males deaths by NSC (ICD-9) in Baixada Santista (BS), from 1980 to 1993 were selected. Mortality ratios were calculated com...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Medrado-Faria MD,de Almeida JW,Zanetta DM,Gattás GJ

    更新日期:2000-06-01 00:00:00

  • Supplementation and therapeutic use of vitamin D in patients with multiple sclerosis: consensus of the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology.

    abstract::Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there is evidence that genetic and environmental factors interact to cause the disease. Among the main environmental factors studied,...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 共识发展会议,杂志文章


    authors: Brum DG,Comini-Frota ER,Vasconcelos CC,Dias-Tosta E

    更新日期:2014-02-01 00:00:00

  • Non-paraneoplastic Lambert-Eaton myasthenic syndrome: a brief review of 10 cases.

    abstract::Lambert-Eaton myasthenic syndrome (LEMS) is an immune-mediated disorder of the presynaptic neuromuscular transmission, which more frequently occurs as the remote effect of a neoplasm, in the paraneoplastic form (P-LEMS), or in a non-paraneoplastic form (NP-LEMS); but few studies describe the clinical features of NP-LE...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Lorenzoni PJ,Scola RH,Kay CS,Parolin SF,Werneck LC

    更新日期:2010-12-01 00:00:00

  • Invasive medullary thymoma associated with Myasthenia gravis: an unusual case.

    abstract::Thymomas are tumors characterized by a remarkable morphological heterogeneity and variable clinical behavior. This tumor has unique clinical associations, most notably with hematological abnormalities and myasthenia gravis. According with the Müller-Hermelink criteria, there are significant differences between the his...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Reis Filho JS,Milanezi MF,Moreira CG,Werneck LC,Boscardin P,Ioshii SO,Schmitt FC

    更新日期:2000-12-01 00:00:00

  • Cerebrovascular disease in neonates. Evaluation of four cases.

    abstract::The clinical and neurological study in four neonates infants with cerebral infarction are reported. The purpose of this study is to call attention for the clinical course, cranial ultrasound, computed tomography and laboratories tests, in order to evaluate the neurological sequelae. A careful evaluation has be taken i...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: De Moura-Ribeiro MV,Pessoto MA,Marba ST

    更新日期:1999-03-01 00:00:00

  • Relationship between pulmonary function, functional independence, and trunk control in patients with stroke.

    abstract:OBJECTIVE:Stroke often leads to abnormalities in muscle tone, posture, and motor control that may compromise voluntary motor function, thus affecting the motor control required for maintaining the synergy of both peripheral and respiratory muscles. To evaluate respiratory muscle strength, pulmonary function, trunk cont...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Santos RSD,Dall'alba SCF,Forgiarini SGI,Rossato D,Dias AS,Forgiarini Junior LA

    更新日期:2019-07-15 00:00:00

  • [Neonatal Streptococcus pyogenes meningitis and sagittal sinus thrombosis: case report].

    abstract::We report a case of Streptococcus pyogenes meningitis in a 18 days year-old-girl with clinical course complicated by sagittal sinus thrombosis. Some aspects of the pathogenesis, treatment and follow-up of the disease are discussed. The world increase of serious streptococcal infections in the last 10 years, probably w...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Krebs VL,Chieffi LN,Jurfest ME,Ceccon R,Diniz EM,Feferbaum R,Takeuchi CA,Marques-Dias MJ,Carneiro JD,Vaz FA

    更新日期:1998-12-01 00:00:00

  • The patient with epilepsy and medicolegal aspects: a view for the neurologist.

    abstract::Patients with epilepsy face innumerable obstacles in daily life, related to work, permission to drive and interpersonal relationships, which require medical guidance. This paper reports a literature review based on scientific articles and civil and traffic system, as a way to resolve doubts about medical obligations i...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Ferreira Neto Segundo A,Silva MME,Mercer PBS,Reinert C,Borges EF,Siqueira JM,Bomediano MP,Witt MCZ

    更新日期:2019-10-24 00:00:00

  • Is phrenic nerve conduction affected in patients with difficult-to-treat asthma?

    abstract::Objective The aim of this study was to obtain data on phrenic neuroconduction and electromyography of the diaphragm muscle in difficult-to-treat asthmatic patients and compare the results to those obtained in controls. Methods The study consisted of 20 difficult-to-treat asthmatic patients compared with 27 controls. S...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Maranhão AA,Rodrigues MMJ,Carvalho SRDS,Caetano MR,Compagnoni IM,Carnio TK,Ribeiro D

    更新日期:2018-03-01 00:00:00

  • Stereotactic biopsy for intracranial lesions: clinical-pathological compatibility in 60 patients.

    abstract:OBJECTIVE:Image guided stereotactic biopsy (SB) provides cerebral tissue samples for histological analysis from minimal lesions or those that are located in deep regions, being crucial in the elaboration of therapeutic strategies, as well as the prevention of unnecessary neurosurgical interventions. METHOD:Sixty patie...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Silva EU,Vasconcellos LP,Lara NA Jr,Veiga JC,Lancellotti CL,Shiozawa P

    更新日期:2009-12-01 00:00:00

  • Pulmonary involvement in patients with HTLV-I associated myelopathy.

    abstract::Pulmonary involvement in HTLV-I patients has been identified by several authors in Africa, Japan and Brazil. The objective of this controlled study is to establish an association between HAM and lymphocytosis in the bronchoalveolar fluid (BAL). Thirty-five adult patients with non-traumatic and non-tumoral myelopathy f...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Mattos K,Melo A,Queiroz C,Publio L,Peçanha-Martins AC,Freitas V,Gomes I

    更新日期:1995-12-01 00:00:00

  • [Coma and transtentorial herniation syndrome due to acute non-expansive hemispheric lesion].

    abstract::An 81-year-old woman developed left hemiplegia and coma due to a right hemisphere infarct and died 6 days later. When first seen in coma she had the classical signs of descending central herniation in the diencephalic stage. The CT scan of the third day showed a large hypodense area occupying the superficial and deep ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: De Oliveira-Souza R,Benchimol M

    更新日期:1995-12-01 00:00:00

  • [Medulloblastomas: clinical, epidemiological and pathological findings in 28 cases].

    abstract::We report the clinical, epidemiological and pathological findings of 28 patients with medulloblastoma: 22 were male; age ranged from 1 to 50 years, with a mean of 15 years. The most frequent symptoms and signs were headache (64%) and vomiting (64%). Only one patient showed a desmoplastic medulloblastoma variant, the o...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Reis Filho JS,Gasparetto EL,Faoro LN,Araújo JC,Torres LF

    更新日期:2000-03-01 00:00:00

  • Interictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers.

    abstract:UNLABELLED:Psychiatric disorders are frequent among patients with epilepsy. Data in the literature have shown a heterogeneous clinical presentation of psychiatric disorders in patients with epilepsy. Interictal dysphoric disorder could be a specific psychiatric comorbidity associated with epilepsy, primarily in patient...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Nascimento PP,Oliva CH,Franco CM,Mazetto L,Yamashiro AS,Araújo Filho GM,Yacubian EM

    更新日期:2013-11-01 00:00:00

  • Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential.

    abstract:BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible loss of cognitive function. The presence of senile plaques is one of the pathological markers of the disease and is associated with the onset of neuroinflammatory mechanisms. The exact pathophysiology of AD...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Sousa JCE,Santana ACF,MagalhÃes GJP

    更新日期:2020-06-08 00:00:00

  • [Fatigability evaluation on multiple sclerosis patients by using a hand held dynamometer].

    abstract::Fatigue is one of the most common disabling symptoms in multiple sclerosis (MS). The aim of this study was to evaluate the fatigability on patients with MS by the application of hand grip isotonic and isometric exercises with dynamometer. As results the fatigability, the isometric strength and time were statistically ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Pavan K,Schmidt K,de Ambrosio Ariça T,Mendes MF,Tilbery CP,Lianza S

    更新日期:2006-06-01 00:00:00

  • The concept of nemesis in psychoneurosis.

    abstract::A patient who has a nemesis fear as the basic process in his psychoneurosis feels that he is destined to repeat the life course of one of his parents to eventual long-term psychosis, or incapacitating physical illness or death by illness or accident. He feels that this will occur at about the same age as that at which...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Chapman AH,Chapman-Santana M,Vieira e Silva D

    更新日期:1997-09-01 00:00:00

  • The functional assessment Berg Balance Scale is better capable of estimating fall risk in the elderly than the posturographic Balance Stability System.

    abstract::The purpose of this study was to verify which instrument better identifies recurrent falls in the elderly. Ninety-eight old people, with an average age of 80 ± 4 years, were submitted to an assessment of balance and fall risk by means of the Berg Balance Scale (BBS) and the posturographic Balance Stability System (BSS...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Pereira VV,Maia RA,Silva SM

    更新日期:2013-01-01 00:00:00

  • [Assessment through P300 of epileptic and non-epileptic children and school performance].

    abstract::Learning disability is common in epileptic children. Epilepsy has been associated with disorders of intelligence. Cognitive potential (P300) is considered to be a clinical aid in the neurophysiological measurement of the cognitive process. Ninety-nine children between the ages of 10 years and 11 years and 11 months fo...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Visioli-Melo JF,Rotta NT

    更新日期:2000-06-01 00:00:00

  • [Carotid endarterectomy under regional anesthesia: follow-up of 104 patients].

    abstract::Cervical carotid stenosis is one of the main causes of ischemic stroke. Carotid endarterectomy is a safe procedure for treatment of moderate and severe symptomatic and asymptomatic carotid stenosis. Regional anesthesia allows neurological evaluation of the patient during the surgery. We reviewed the results of 104 pat...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Raso J,Lopes F,Serrano P,Locarno A,Frota EC,Cariri GA

    更新日期:2004-09-01 00:00:00

  • Evaluation of intense physical effort in subjects with temporal lobe epilepsy.

    abstract::People with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Although the beneficial effect of aerobic exercise in people with epilepsy, little objective evidence regarding the intensity of exercise has been reported. We investigated the effect of...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Camilo F,Scorza FA,de Albuquerque M,Vancini RL,Cavalheiro EA,Arida RM

    更新日期:2009-12-01 00:00:00

  • The presence of antiautonomic membrane receptor antibodies do not correlate with brain lesions in Chagas' disease.

    abstract:UNLABELLED:We previously demonstrated correlation between parasympathetic dysfunction and brain white matter lesions in chronic chagasic patients. OBJECTIVE:To correlate serum functional circulating antibodies with beta adrenergic (Ab-beta), muscarinic (Ab-M) or muscarinic and beta adrenergic (Ab-Mbeta) activity, the ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Py MO,Maciel L,Pedrosa RC,Nascimento JH,Medei E

    更新日期:2009-09-01 00:00:00

  • [Dermatopolymyositis: evaluation of 63 patients].

    abstract::Sixty-three patients with dermatopolymyositis were evaluated from the clinical, laboratory and therapeutical aspects during a period of 15 years: 39 are women and 24 men. The mean age was 36.8 +/- 15.6 years. No correlation was observed between clinical and isolated therapeutics employed; when corticosteroids and cyto...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Marchiori PE,Hirata MT,Scaff M,de Oliveira RM,Cossermelli W,Levy JA,de Assis JL

    更新日期:1987-06-01 00:00:00

  • Professor Octávio de Silveira: the pioneer of neurology in the State of Paraná.

    abstract::The author gives a brief overview of the career of Professor Octávio da Silveira, the first neurologist and professor of neurology in the State of Paraná, as well as the first full professor of clinical neurology in the Federal University of Paraná. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 传,历史文章,杂志文章


    authors: Teive HA

    更新日期:2008-09-01 00:00:00

  • Cerebellar glioblastoma multiforme in an adult.

    abstract::Cerebellar glioblastoma multiforme (GBM) is a rare tumor. This is the third case published in Brazilian literature and, the last one has been described more than 15 years ago. The aggressive behavior of GBM prompts for fast treatment, which can be hampered by the fact that the diagnosis of GBM requires a high degree o...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Mattos JP,Marenco HA,Campos JM,Faria AV,Queiroz LS,Borges G,Oliveira Ed

    更新日期:2006-03-01 00:00:00