Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: a comprehensive alternative.

Abstract:

:Since the first report addressing quantification of cerebral blood flow (CBF), concomitant assessment of cerebral oxygen consumption was also carried out. Over the years, however, some investigators have emphatically and mistakenly addressed cerebral ischemia in comatose patients, on the basis of CBF measurements alone. In contrast, we have repeatedly reported that ischemia in these patients must be precisely evaluated based on CBF-metabolism coupling or uncoupling, rather than CBF alone. Based on these previous findings, we therefore propose a comprehensive alternative approach, namely the evaluation of brain ischemia in comatose patients based on cerebral metabolic parameters, such as cerebral extraction of oxygen or cerebral lactate release, without expensive CBF measurements.

journal_name

Arq Neuropsiquiatr

authors

Cruz J

doi

10.1590/s0004-282x2003000200031

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

309-12

issue

2A

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2003000200031

journal_volume

61

pub_type

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