Antimicrobial proficiency testing of National Nosocomial Infections Surveillance System hospital laboratories.


OBJECTIVE:The National Nosocomial Infections Surveillance (NNIS) System personnel report trends in antimicrobial-resistant pathogens. To validate select antimicrobial susceptibility testing results and to identify test methods that tend to produce errors, we conducted proficiency testing among NNIS System hospital laboratories. SETTING:NNIS System hospital laboratories in the United States. METHODS:Each laboratory received five organisms (ie, an imipenem-resistant Serratia marcescens, an oxacillin-resistant Staphylococcus aureus, a vancomycin-resistant Enterococcus faecalis, a vancomycin-intermediate Staphylococcus epidermidis, and an extended-spectrum beta-lactamase (ESbetaL)-producing Klebsiella pneumoniae). Testing results were compared with reference testing results from the Centers for Disease Control and Prevention. RESULTS:Of 138 laboratories testing imipenem against the Serratia marcescens strain, 110 (80%) correctly reported minimum inhibitory concentrations (MICs) or zone sizes in the resistant range. All 193 participating laboratories correctly reported the Staphylococcus aureus strain as oxacillin resistant Of the 193 laboratories, 169 (88%) reported correct MICs or zone sizes for the vancomycin-resistant Enterococcus faecalis. One hundred sixty-two (84%) of 193 laboratories demonstrated the ability to detect a vancomycin-intermediate strain of Staphylococcus epidermidis, however, disk diffusion performed poorly when testing both staphylococci and enterococci with vancomycin. Although laboratory personnel correctly reported nonsusceptible extended-spectrum cephalosporins and aztreonam results for K. pneumoniae, only 98 (51%) of 193 correctly reported this organism as an ESbetaL producer. CONCLUSION:Overall, NNIS System hospital laboratory personnel detected most emerging resistance patterns. Disk diffusion continues to be unreliable for vancomycin testing of staphylococci and must be used cautiously for enterococci. Further education on the processing of ESbetaL-producing organisms is warranted.


Hageman JC,Fridkin SK,Mohammed JM,Steward CD,Gaynes RP,Tenover FC,National Nosocomial Infections Surveillance System Hospitals.




Has Abstract


2003-05-01 00:00:00














  • Evaluation of the microbiology of soft-tissue abscesses in the era of community-associated strains of methicillin-resistant Staphylococcus aureus: an argument for empirical contact precautions.

    abstract::To ascertain the microbiology of skin abscesses, emergency department records were reviewed to identify patients with debrided skin abscesses. Methicillin-resistant Staphylococcus aureus was isolated from 255 (67.6%) of 377 culture samples from episodes in the adult cohort and from 145 (79.7%) of 182 culture samples f...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Talbot TR,Nania JJ,Wright PW,Jones I,Aronsky D

    更新日期:2007-06-01 00:00:00

  • Chloramphenicol resistance in vancomycin-resistant enterococcal bacteremia: impact of prior fluoroquinolone use?

    abstract:OBJECTIVE:The prevalence of vancomycin-resistant enterococci (VRE) has increased markedly during the past decade. Few data exist regarding the epidemiology of resistance of VRE to chloramphenicol, one of the few therapeutic options. DESIGN:Survey and case-control study. SETTING:A 725-bed, tertiary-care academic medic...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Gould CV,Fishman NO,Nachamkin I,Lautenbach E

    更新日期:2004-02-01 00:00:00

  • Compliance with national recommendations for tuberculosis screening and immunization of healthcare workers in a children's hospital.

    abstract::Physicians and clinical employees at a children's hospital were surveyed to compare their tuberculosis (TB) screening and immunization statuses. Failure to offer screening and immunization services to non-employee physicians was associated with lower rates of reported immunity to several vaccine-preventable diseases a...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Bratcher DF,Stover BH,Lane NE,Paul RI

    更新日期:2000-05-01 00:00:00

  • Infection control practices to reduce airborne bacteria during total knee replacement: a hospital survey in four states.

    abstract:OBJECTIVE:To describe the use of laminar airflow, body exhaust, and ultraviolet lights during total knee replacement (TKR) in four U.S. states. DESIGN:Survey of healthcare facilities. SETTING:Hospitals in Illinois, North Carolina, Ohio, and Tennessee that performed TKR during 2000 as identified by Medicare claims dat...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Miner AL,Losina E,Katz JN,Fossel AH,Platt R

    更新日期:2005-12-01 00:00:00

  • Cohorting KPC+ Klebsiella pneumoniae (KPC-Kp)-positive patients: A genomic exposé of cross-colonization hazards in a long-term acute-care hospital (LTACH).

    abstract:OBJECTIVE:Cohorting patients who are colonized or infected with multidrug-resistant organisms (MDROs) protects uncolonized patients from acquiring MDROs in healthcare settings. The potential for cross transmission within the cohort and the possibility of colonized patients acquiring secondary isolates with additional a...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Hawken SE,Hayden MK,Lolans K,Yelin RD,Weinstein RA,Lin MY,Snitkin ES

    更新日期:2020-10-01 00:00:00

  • An investigation of potential neurosurgical transmission of Creutzfeldt-Jakob disease: challenges and lessons learned.

    abstract::In 2001, New York State health officials were notified about 2 patients with Creutzfeldt-Jakob disease who had undergone neurosurgical procedures at the same hospital within 43 days of each other. One patient had Creutzfeldt-Jakob disease at the time of surgery; the other patient developed Creutzfeldt-Jakob disease 6....

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Stricof RL,Lillquist PP,Thomas N,Belay ED,Schonberger LB,Morse DL

    更新日期:2006-03-01 00:00:00

  • Activity of three disinfectants and acidified nitrite against Clostridium difficile spores.

    abstract:OBJECTIVE:To identify environmentally safe, rapidly acting agents for killing spores of Clostridium difficile in the hospital environment. DESIGN:Three classic disinfectants (2% glutaraldehyde, 1.6% peracetyl ions, and 70% isopropanol) and acidified nitrite were compared for activity against C. difficile spores. Four ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Wullt M,Odenholt I,Walder M

    更新日期:2003-10-01 00:00:00

  • Differences in hand hygiene behavior related to the contamination risk of healthcare activities in different groups of healthcare workers.

    abstract:BACKGROUND:The Fulkerson scale lists 15 typical clinical activities ranked according to their risk of hand contamination. OBJECTIVE:To investigate how often healthcare workers (HCWs) apply antiseptic handrubs after each of the specified activities ranked in the Fulkerson scale. DESIGN:Observational study. SETTING:Un...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Wendt C,Knautz D,von Baum H

    更新日期:2004-03-01 00:00:00

  • The continuing evolution of methicillin-resistant Staphylococcus aureus in Western Australia.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has been notifiable in Western Australia since 1985. This article reviews the notification data from 1994 to 1997, focusing on increases in MRSA notifications and the proportion that are local strains; changes in the geographical distribution of MRSA; and changes in a...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Torvaldsen S,Roberts C,Riley TV

    更新日期:1999-02-01 00:00:00

  • Evidence of delays in transferring patients with methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus to long-term-care facilities.

    abstract::This retrospective case-control study examined whether there was a difference in length of time awaiting long-term-care placement for patients identified as having methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus compared to controls. Thirty-nine patients with methicillin-resistant Stap...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Bryce EA,Tiffin SM,Isaac-Renton JL,Wright CJ

    更新日期:2000-04-01 00:00:00

  • Clostridium difficile in long-term-care facilities for the elderly.

    abstract::Antimicrobial agents are among the most frequently prescribed medications in long-term-care facilities (LTCFs). Therefore, it is not surprising that Clostridium difficile colonization and C. difficile-associated diarrhea (CDAD) occur commonly in elderly LTCF residents. C. difficile has been identified as the most comm...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,评审


    authors: Simor AE,Bradley SF,Strausbaugh LJ,Crossley K,Nicolle LE,SHEA Long-Term-Care Committee.

    更新日期:2002-11-01 00:00:00

  • Surgical site infections following hip and knee arthroplastic surgery: Trends and risk factors of Staphylococcus aureus infections.

    abstract::We investigated surgical site infections (SSIs) following hip and knee arthroplasties to evaluate predictors of SSI. We found a significant increase in deep Staphylococcus aureus (SA) SSIs despite the decreasing overall SSI rate. The risk of deep SA-SSI differed between genders and among age groups and was affected by...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Prattingerová J,Sarvikivi E,Huotari K,Ollgren J,Lyytikäinen O

    更新日期:2019-02-01 00:00:00

  • Attributable morbidity and mortality of catheter-related septicemia in critically ill patients: a matched, risk-adjusted, cohort study.

    abstract:OBJECTIVE:To determine the attributable risk of death due to catheter-related septicemia (CRS) in critically ill patients when taking into account severity of illness during the intensive-care unit (ICU) stay but before CRS. DESIGN:Pairwise-matched (1:2) exposed-unexposed study. SETTING:10-bed medical-surgical ICU an...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Soufir L,Timsit JF,Mahe C,Carlet J,Regnier B,Chevret S

    更新日期:1999-06-01 00:00:00

  • Influenza vaccination and intention to receive the pandemic H1N1 influenza vaccine among healthcare workers of British Columbia, Canada: a cross-sectional study.

    abstract:OBJECTIVE:To assess healthcare workers' attitudes and concerns regarding seasonal and pandemic influenza vaccines in order to improve vaccination campaign communications. DESIGN:Cross-sectional survey. SETTING:All 6 health authorities in British Columbia, Canada. METHODS:An anonymous, self-administered online survey...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Kaboli F,Astrakianakis G,Li G,Guzman J,Donovan T,Naus M

    更新日期:2010-10-01 00:00:00

  • Intravascular catheter colonization in critically ill children.

    abstract::In a prospective study, cultures were obtained of all intravascular catheters removed from children in an intensive care unit. Of 366 catheters removed from 217 children, 110 (30%) were found to be colonized, most commonly with coagulase-negative staphylococci. Despite the high rate of colonization, there were only ni...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Schlager TA,Hidde M,Rodger P,Germanson TP,Donowitz LG

    更新日期:1997-05-01 00:00:00

  • Recovery of Pseudomonas cepacia and other Pseudomonas species from the environment.

    abstract::Nine hundred sixteen cultures were obtained from homes of patients with cystic fibrosis, control homes, salad bars, and food markets, and analyzed for the presence of Pseudomonas cepacia and related bacteria. P cepacia was recovered from 5 (18%) of 27 homes, and from 20 (4%) of 509 cultures collected outside of homes....

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Mortensen JE,Fisher MC,LiPuma JJ

    更新日期:1995-01-01 00:00:00

  • A bronchoscopy-associated pseudo-outbreak of Mycobacterium mucogenicum traced to use of contaminated ice used for bronchoalveolar lavage.

    abstract::Clonal Mycobacterium mucogenicum isolates (determined by molecular typing) were recovered from 19 bronchoscopic specimens from 15 patients. None of these patients had evidence of mycobacterial infection. Laboratory culture materials and bronchoscopes were negative for Mycobacteria. This pseudo-outbreak was caused by c...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Bringhurst J,Weber DJ,Miller MB,Jones MC,Rivera MP,Akulian J,Rutala WA,Sickbert-Bennett EE

    更新日期:2020-01-01 00:00:00

  • Poor functional status as a risk factor for surgical site infection due to methicillin-resistant Staphylococcus aureus.

    abstract:OBJECTIVE:To identify risk factors for surgical site infection (SSI) due to methicillin-resistant Staphylococcus aureus (MRSA). DESIGN:Prospective case-control study. SETTING:One tertiary and 6 community-based institutions in the southeastern United States. METHODS:We compared patients with SSI due to MRSA with 2 co...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Anderson DJ,Chen LF,Schmader KE,Sexton DJ,Choi Y,Link K,Sloane R,Kaye KS

    更新日期:2008-09-01 00:00:00

  • Subungual bacteria of the hand: contribution to the glove juice test; efficacy of antimicrobial detergents.

    abstract::Methodologies for evaluating the efficacy of antimicrobial agents in the bacterial flora of the hand involve variations of the "glove juice" or "sterile bag" procedures. In this study we demonstrate that the subungual flora contribute significantly to the recovery of bacteria in these procedures. Culturing hands that ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 临床试验,杂志文章


    authors: Leyden JJ,McGinley KJ,Kates SG,Myung KB

    更新日期:1989-10-01 00:00:00

  • Patient Safety Culture and the Ability to Improve: A Proof of Concept Study on Hand Hygiene.

    abstract::OBJECTIVE To investigate whether the safety culture of a hospital unit is associated with the ability to improve. DESIGN Qualitative investigation of safety culture on hospital units following a before-and-after trial on hand hygiene. SETTING VU University Medical Center, a tertiary-care hospital in the Netherlands. M...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Caris MG,Kamphuis PGA,Dekker M,de Bruijne MC,van Agtmael MA,Vandenbroucke-Grauls CMJE

    更新日期:2017-11-01 00:00:00

  • The impact of surgical site infections on hospital contribution margin-a European prospective observational cohort study.

    abstract:BACKGROUND:Surgical site infections (SSIs) are common surgical complications that lead to increased costs. Depending on payer type, however, they do not necessarily translate into deficits for every hospital. OBJECTIVE:We investigated how surgical site infections (SSIs) influence the contribution margin in 2 reimburse...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: von Strauss M,Marti WR,Mujagic E,Coslovsky M,Diernberger K,Hall P,Zeindler J,Salm LA,Soysal SD,Mechera R,von Holzen U,Weber WP

    更新日期:2019-12-01 00:00:00

  • The Use of Channel-Purge Storage for Gastrointestinal Endoscopes Reduces Microbial Contamination.

    abstract::Storage cabinets for heat-sensitive endoscopes (SCHEs) are designed to store gastrointestinal (GI) endoscopes in a clean, dry and well-ventilated cupboard to prevent microbiological proliferation. The use of SCHEs in a GI endoscopy unit has significally reduced the rate of contaminated endoscopes (13.0% vs 45.0%, P<.0...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Saliou P,Cholet F,Jézéquel J,Robaszkiewicz M,Le Bars H,Baron R

    更新日期:2015-09-01 00:00:00

  • Harnessing claims to improve detection of surgical site infections following hysterectomy and colorectal surgery.

    abstract::Surgical site infection (SSI) surveillance is performed using a variety of methods with unclear performance characteristics. We used claims data to identify records for review following hysterectomy and colorectal surgery. Claims-enhanced screening identified SSIs missed by routine surveillance and could be used for t...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Letourneau AR,Calderwood MS,Huang SS,Bratzler DW,Ma A,Yokoe DS

    更新日期:2013-12-01 00:00:00

  • Colonization sites of USA300 methicillin-resistant Staphylococcus aureus in residents of extended care facilities.

    abstract:BACKGROUND:The anterior nares are the most sensitive single site for detecting methicillin-resistant Staphylococcus aureus (MRSA) colonization. Colonization patterns of USA300 MRSA colonization are unknown. OBJECTIVES:To assess whether residents of extended care facilities who are colonized with USA300 MRSA have diffe...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Shurland SM,Stine OC,Venezia RA,Johnson JK,Zhan M,Furuno JP,Miller RR,Johnson T,Roghmann MC

    更新日期:2009-04-01 00:00:00

  • Central line-associated bloodstream infection in neonatal intensive care units.

    abstract:OBJECTIVE:Describe the epidemiology of central line-associated bloodstream infections (CLABSIs) in neonatal intensive care units (NICUs) participating in a standardized and mandatory CLABSI surveillance program. DESIGN:Retrospective cohort. Setting. We included patients admitted (April 2007-March 2011) to 7 level II/I...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Blanchard AC,Fortin E,Rocher I,Moore DL,Frenette C,Tremblay C,Quach C

    更新日期:2013-11-01 00:00:00

  • Ultraviolet powder versus ultraviolet gel for assessing environmental cleaning.

    abstract::We compared cleaning rates associated with use of a white ultraviolet (UV) powder versus a transparent UV gel among units with various degrees of previous experience with UV powder. The study outcome was the presence of discordant cleaning (removal of powder without the removal of gel, or vice versa). We found higher ...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Munoz-Price LS,Fajardo-Aquino Y,Arheart KL

    更新日期:2012-02-01 00:00:00

  • Regulation of topical antimicrobials: history, status and future perspective.

    abstract::Antimicrobial agents used as disinfectants and antiseptics are increasing in epidemiologic importance. The regulation of topical antiseptics has ranged from nonexistent, lax and confusing to inclusion in the Food and Drug Administration (FDA) over-the-counter (OTC) review of drug ingredients. This article simplifies t...

    journal_title:Infection control and hospital epidemiology

    pub_type: 历史文章,杂志文章


    authors: Bruch MK,Larson E

    更新日期:1989-11-01 00:00:00

  • Prevalence survey on catheter-associated urinary tract infection (CAUTI) in public hospitals in Hong Kong 2018.

    abstract::We conducted a survey of 16,914 patients to determine the point prevalence of healthcare-associated catheter-associated urinary tract infection (HA-CAUTI) and urinary catheter care in public hospitals in Hong Kong. Overall HA-CAUTI prevalence was 0.27%. Compliance was generally good, except for documenting the date of...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Chen H,Lee JWY,Yu KCH,Chan CKW,Wong ATY,Lai RWM,Fung KSC

    更新日期:2020-03-01 00:00:00

  • Prevalence of hospital antibiotic use in Argentina, 2018.

    abstract::Hospital antibiotic use in Argentina has not been described. We present results of point prevalence surveys on antibiotic use conducted in 109 Argentinian hospitals in November 2018 and submitted to the National Program of Epidemiology and Control of Hospital-Acquired Infections, and we discuss potential areas for imp...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Peralta N,Camou BI,Leszczuk K,Arcidiácono D,Lerena RG,Herrera P,Cornistein W,Riera F,Cosgrove SE,Fabre V

    更新日期:2019-11-01 00:00:00

  • Evaluation of a rapid readout biological indicator for flash sterilization with three biological indicators and three chemical indicators.

    abstract:OBJECTIVE:Flash sterilization is most commonly used for emergency sterilization of unwrapped items in a gravity displacement sterilizer for three minutes. Sterilization quality assurance is monitored by biological indicators that require a 24-hour incubation prior to reading. In this study, we compared a new biological...

    journal_title:Infection control and hospital epidemiology

    pub_type: 杂志文章


    authors: Rutala WA,Gergen MF,Weber DJ

    更新日期:1993-07-01 00:00:00