Abstract:
:Diabetes mellitus has become the most common single cause of end-stage renal disease in the Western world. Diabetic nephropathy, as most forms of renal disease leading to end-stage renal failure, is frequently complicated by arterial hypertension. In type 1 diabetes mellitus the reported excess in arterial hypertension is almost entirely accounted for by patients who develop persistent proteinuria, and the cumulative incidence of hypertension and proteinuria in this population displays a virtually superimposable pattern. In both type 1 and type 2 diabetes mellitus, the level of arterial hypertension closely correlates with the subsequent decline in glomerular filtration rate and with accelerated renal damage.
journal_name
Drugsjournal_title
Drugsauthors
Viberti Gsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
31-7eissn
0012-6667issn
1179-1950pii
630004journal_volume
63 Spec No 1pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Bisoprolol is a beta 1-adrenoceptor antagonist with no partial agonist (intrinsic sympathomimetic) activity or membrane stabilising (local anaesthetic) activity. The oral bioavailability of bisoprolol is high (90%) and the drug has a long elimination half-life which allows once-daily administration; in addition, it is...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198836030-00002
更新日期:1988-09-01 00:00:00
abstract::Methylnaltrexone is a selective mu-opioid receptor antagonist that has restricted ability to cross the blood-brain barrier, thus enabling reversal of opioid-induced peripheral effects, such as constipation, without affecting the central effects, such as pain relief. Treatment with subcutaneous methylnaltrexone 0.15-0....
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11204520-000000000-00000
更新日期:2010-05-07 00:00:00
abstract::The most positive results in this area have been those of the second Danish Study Group on Verapamil in Myocardial Infarction (1990) which assessed the benefit of treatment with verapamil from the second week after myocardial infarction. Verapamil produced a significant reduction in both mortality and reinfarction rat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199100421-00005
更新日期:1991-01-01 00:00:00
abstract::Entecavir (Baraclude) is a novel nucleoside analogue of 2'-deoxyguanosine whose intracellular triphosphate form inhibits replication of the hepatitis B virus (HBV). In large, randomised, double-blind, phase III clinical trials in patients with chronic HBV infection, oral entecavir 0.5 or 1.0mg once daily for up to 96 ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666120-00009
更新日期:2006-01-01 00:00:00
abstract::Janus kinase (JAK) is a signal transducer and activator of a protein transcription system that transduces signals from cell surface cytokine and growth factor receptors to the nucleus. Recently developed JAK inhibitors (JAKinibs) inhibit JAKs non-selectively or selectively and down-regulate the effects of correspondin...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01349-1
更新日期:2020-08-01 00:00:00
abstract::Colloid solutions have been developed and used over the past 70 years as expanders of the intravascular space, based on an understanding of Starling's law. Increasing osmotic pressure with colloidal products has remained an attractive theoretical premise for volume resuscitation. Indeed, colloids have been shown to in...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199855050-00002
更新日期:1998-05-01 00:00:00
abstract::The selective sodium hydrogen exchanger 3 (NHE3) inhibitor tenapanor is being developed by Ardelyx Inc. for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) [under the tradename IBSRELA®] and for hyperphosphataemia in patients with chronic kidney disease (CKD) on dialysis or with end stage re...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01215-9
更新日期:2019-11-01 00:00:00
abstract::The meningococcal groups C and Y and Haemophilus b (Hib) tetanus toxoid conjugate vaccine (HibMenCY-TT) contains Neisseria meningitidis serogroup C and Y capsular polysaccharide antigens, and Hib capsular polysaccharide [polyribosyl-ribitol-phosphate (PRP)]. The HibMenCY-TT vaccine is available in the USA for use as a...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0048-9
更新日期:2013-05-01 00:00:00
abstract::Until recently, patients with advanced thyroid cancers had limited options for systemic treatment. With the introduction of tyrosine kinase inhibitors (TKIs) as a promising new class of targeted therapies for thyroid cancer, suddenly patients with advanced disease were given new options to extend survival. Guidelines ...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-017-0733-1
更新日期:2017-05-01 00:00:00
abstract::Viral conjunctivitis is one of the most common disorders observed in ophthalmic emergency departments, yet no established treatment exists. Lately, antiviral medications have been introduced into clinical practice; however, a systematic review focusing on their use and effectiveness in the treatment of viral conjuncti...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11585330-000000000-00000
更新日期:2011-02-12 00:00:00
abstract::Capecitabine is an orally administered fluoropyrimidine carbamate used for the treatment of paclitaxel- or anthracycline-refractory breast cancer. Capecitabine is metabolised via a 3-step process to the active agent fluorouracil. The final step of this process occurs preferentially in malignant tissue. In patients wit...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958010-00006
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:The lowering of cholesterol concentrations in individuals at high risk of cardiovascular disease improves outcome. No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemi...
journal_title:Drugs
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2165/00003495-200464002-00005
更新日期:2004-01-01 00:00:00
abstract::Several antihypertensive agents such as thiazide diuretics and some beta-blockers have recently been shown to adversely affect lipid metabolism. Moreover, there is a growing suspicion that the adverse effect on plasma lipids might outweigh the favourable effect of lowering blood pressure. The effect of ketanserin tart...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-198800361-00006
更新日期:1988-01-01 00:00:00
abstract::Although the incidence of HIV-associated cryptococcosis has decreased in developed countries since the introduction of antiretroviral therapy, this disease continues to cause significant morbidity and mortality in sub-Saharan Africa among patients with AIDS. Important strides have been made in an attempt to decrease t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0037-z
更新日期:2013-05-01 00:00:00
abstract::Sulbactam is a semisynthetic beta-lactamase inhibitor which when combined with certain beta-lactam antibacterials extends their activity against bacteria that are normally resistant to the antibiotic due to production of beta-lactamases. In combination with ampicillin it extends the antibacterial activity of ampicilli...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198733060-00003
更新日期:1987-06-01 00:00:00
abstract::Lung tissue remodelling in chronic inflammatory lung diseases has long been regarded as a follow-up event to inflammation. Recent studies have indicated that, although airway and lung tissue remodelling is often independent of inflammation, it precedes or causes inflammation. None of the available therapies has a sign...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0319-0
更新日期:2015-01-01 00:00:00
abstract::25 years have elapsed since the introduction of the first effective oral diuretic, chlorothiazide. Diuretics are now amongst the most widely prescribed drugs in clinical practice worldwide. Availability of these drugs has not only brought therapeutic benefit to countless numbers of patients but it has at the same time...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198529020-00003
更新日期:1985-02-01 00:00:00
abstract::Aripiprazole (Abilify®) is an atypical antipsychotic indicated for the treatment of mania associated with bipolar I disorder. It is unique in its class, as it is a partial agonist of dopamine D(2) and D(3), and serotonin 5-HT(1A) receptors and a modest antagonist of 5-HT(2A) receptors. This article reviews the pharmac...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11208320-000000000-00000
更新日期:2012-01-01 00:00:00
abstract::Isradipine, a dihydropyridine derivative, inhibits the inward calcium flux through 'slow' channels of cardiac and vascular tissue, thereby eliciting potent coronary, cerebral and peripheral vasodilatation. In comparison with other calcium channel blockers the drug offers the advantages of minimal cardiodepressant acti...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199040010-00004
更新日期:1990-07-01 00:00:00
abstract::Clopidogrel is a thienopyridine that irreversibly inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled ADP receptors on the platelet surface. In animal models, clopidogrel reduced the formation of both arterial and venous thrombi. After oral administration, clopidogrel is rapidly absorbed ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199754050-00006
更新日期:1997-11-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is a leading cause of cancer death in industrialised countries, with an overall 5-year survival rate of less than 10%. Good patient performance status is associated with a significantly improved prognosis, whereas the presence of metastases, particularly to the bone or liver, is asso...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200444-00006
更新日期:1992-01-01 00:00:00
abstract::The efficacy and safety of rectally administered nimesulide 200mg and paracetamol 500mg were assessed in a double-blind study. The study was conducted in 39 elderly inpatients with infections of the upper or lower respiratory tract associated with fever; 18 patients received nimesulide and 21 received paracetamol. Bot...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-199300461-00026
更新日期:1993-01-01 00:00:00
abstract::Empagliflozin/linagliptin (Glyxambi(®)) is a once-daily sodium glucose co-transporter type 2 (SGLT2) inhibitor and dipeptidyl peptidase (DPP)-4 inhibitor fixed-dose combination product that is approved in the USA as an adjunct to diet and exercise in adults with type 2 diabetes (T2D) when treatment with both empaglifl...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0457-z
更新日期:2015-09-01 00:00:00
abstract::The 'funny' (pacemaker, I(f)) current, first described almost 30 years ago in sinoatrial node (SAN) myocytes, is a mixed sodium/potassium inward current, activated on hyperpolarisation in the diastolic range of voltages. 'Funny' (f) channels are activated by intracellular cyclic adenosine monophosphate (cAMP) concentr...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767002-00003
更新日期:2007-01-01 00:00:00
abstract::Locally advanced prostate cancer (LAPC) is a heterogeneous entity usually embracing T3-4 and/or pelvic lymph-node-positive disease in the absence of established metastases. Outcomes for LAPC with single therapies have traditionally been poor, leading to the investigation of adjuvant therapies. Prostate cancer is a hor...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11591500-000000000-00000
更新日期:2011-05-28 00:00:00
abstract::Iloprost is an analogue of epoprostenol (prostacyclin; PGI2; a potent but short-lived prostanoid mainly produced in the vascular endothelium) and mimics the pharmacodynamic properties of this compound, namely: inhibition of platelet aggregation, vasodilatation and, as yet ill-defined, cytoprotection. Improved metaboli...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199243060-00008
更新日期:1992-06-01 00:00:00
abstract::Migalastat (Galafold™)-a small molecule drug developed by Amicus Therapeutics that restores the activity of specific mutant forms of α-galactosidase-has been approved for the treatment of Fabry disease in the EU in patients with amenable mutations. Fabry disease is a rare disorder that results in a deficiency or absen...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-016-0607-y
更新日期:2016-07-01 00:00:00
abstract::Echinocandins are a new class of antifungal agents with a novel mechanism of action (interference with fungal cell wall synthesis). Caspofungin (Cancidas), Caspofungin MSD) is the first echinocandin to be approved and is administered intravenously. Caspofungin 50 mg/day had similar efficacy to intravenous fluconazole ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200363200-00008
更新日期:2003-01-01 00:00:00
abstract::The size of the antibiotic market in developing countries is double that seen in developed countries. There are some valid reasons for this difference, one of which is the higher frequency of diverse infections in the developing world. However, other factors are involved: for example, antibiotics are available without...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199300453-00009
更新日期:1993-01-01 00:00:00
abstract::Invasive candidiasis has emerged as an important cause of morbidity and mortality in intensive care unit patients. This short review focuses on many aspects of Candida infection in critically ill patients including epidemiology, impact on mortality, problems related to diagnosis, strategies to identify patients at ris...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11315590-000000000-00000
更新日期:2009-01-01 00:00:00