Abstract:
:In recent years randomized trials designed to establish non-inferiority of a new treatment as compared to a standard one have been more widely used. Two-sample statistics have been proposed for this equivalence testing problem. However, they are not suited to situations where a long-term survivor fraction is expected. In this paper we propose a score test designed for establishing non-inferiority for the new treatment as compared to the standard one while assuming identical long-term survivor rates. Simulations results show that the proposed statistic has satisfactory size and power as long as certain restricting conditions are verified. A breast cancer trial is analysed as an example.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Broët P,Tubert-Bitter P,De Rycke Y,Moreau Tdoi
10.1002/sim.1453subject
Has Abstractpub_date
2003-03-30 00:00:00pages
931-40issue
6eissn
0277-6715issn
1097-0258journal_volume
22pub_type
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