Abstract:
:Trichloroethylene (TCE) is widely used as an industrial solvent and cleaning fluid. In the present study the toxic effects of TCE inhalation on pulmonary and hepatic biotransformation enzymes in rats have been investigated by assay of aniline hydroxylase (AH), aminopyrine-N-demethylase (APD), benzo-a-pyrene hydroxylase (BH) and glutathione-s-transferase (GST) activities and glutathione (GSH) contents in liver as well as lungs of exposed animals. In both organs phase I and phase II drug metabolizing enzymes have been found to be increased along with decrease in GSH contents following TCE inhalation. Pulmonary as well as hepatic MFO's seem to be activated by inhaled TCE probably in an attempt for its rapid detoxification and reduced glutathione is used during its biotransformation.
journal_name
J Environ Bioljournal_title
Journal of environmental biologyauthors
Kumar P,Prasad AK,Mani U,Maji BK,Dutta KKsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
1-6issue
1eissn
0254-8704issn
2394-0379journal_volume
23pub_type
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journal_title:Journal of environmental biology
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journal_title:Journal of environmental biology
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